Due to the robust electrophilic properties of the trifluoromethyl group (-CF3), its incorporation into
organic compounds can markedly alter their ester affinity, stability, bioavailability, and other properties. The
trifluoromethylation reaction is currently experiencing rapid advancement, with an expanding array of substrates
and the emergence of novel methodologies. Consequently, compounds containing the -CF3 moiety find
extensive utility across diverse fields. This article aims to comprehensively review the latest advancements in
trifluoromethylation reaction of olefins, aldehydes, and ketones, encompassing nucleophilic trifluoromethylation,
electrophilic trifluoromethylation, and radical trifluoromethylation. The discussion includes an exploration
of the types and broadening scope of applicable substrates. Furthermore, this article addresses the associated
challenges and delineates prospective directions for future developments in trifluoromethyl reaction.