The Addition Compounds of Olefins with Mercuric Salts.

Chatt, J.

doi:10.1021/cr60149a002

Cited by 180 publications

(40 citation statements)

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“…If there is a change in permeability, it does not seem to be related to basic structural changes since mitochondrial fatty acid composition was not altered by these treatments, and the susceptibility of isolated mitochondria to rupture by freezing and thawing was not affected. Such a change in permeability might be related to mercury binding to the lipid (Chatt, 1951;Wright, 1957) and/or the protein (Barron and Kalnitsky, 1947;Hughes and Dintzis, 1964;Takeda et al, 1958) moieties of the membrane. It should be noted that the 8 g fractions were isolated under conditions which cause minimal mitochondrial rupture.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Mercury Ingestion on Hepatic Mitochondrial Membranes of Chicks

Donaldson

1976

Poultry Science

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Cytochrome c oxidase activity was measured in livers of chicks receiving 0, 200,250 or 300 p.p.m. mercury (as HgC12) in the drinking water beginning at one week of age. In the first experiment treatment with 200 p.p.m. mercury for up to 4 weeks tended to increase the activity of cytochrome c oxidase and decrease the proportion of free (measured in untreated liver preparations) to total (measured in Triton X-100 treated liver preparations) enzyme activity as compared with controls. However, the differences, which appeared after 1 week of treatment were not always statistically significant. The fatty acid composition of mitochondrial lipids was not affected by treatment with 200 p.p.m. mercury for 4 weeks. In the second experiment, treatment with 300 p.p.m. mercury for 4 weeks resulted in significantly higher total cytochrome c oxidase specific activity and a significantly lower proportion of free to total enzyme activity as compared with controls. However, mitochondrial susceptibility to rupture by freezing and thawing was not affected. In the third experiment chicks were given 250 p.p.m. mercury in the drinking water from 1 through 9 weeks of age. The mercury-treated chicks exhibited severe tremors at 9 weeks while the controls were unaffected. Cytochome c oxidase total specific activity was significantly reduced in trembling chicks, and the proportion of free to total enzyme activity was significantly increased as was the susceptibility of isolated mitochondria to rupture by freezing and thawing. The data suggest that moderate levels of mercury administered over an 8 week period can affect adversely the integrity of mitochondrial membranes.

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Section: Discussionmentioning

confidence: 99%

The Effects of Mercury Ingestion on Hepatic Mitochondrial Membranes of Chicks

Donaldson

1976

Poultry Science

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“…A number of kinetic studies (352,(359)(360)(361) show that the rate is first order in olefin and first order in mercuric salt. In hydroxylic media, the solvent It is of interest to compare these results with those obtained from studies of the oxymercuration reaction.…”

Section: R C Faheymentioning

confidence: 99%

The Stereochemistry of Electrophilic Additions to Olefins and Acetylenes

Fahey

1968

Topics in Stereochemistry

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“…Durch Aminoniercurierung und Demercurierung von Olefinen lassen sich neuartige heterocyclische Systeme aufbauen [ 31. Die Umsetzung von Organoquecksilberverbindungen mit NaBH, fuhrt in einer praparativ wichtigen Reaktion [4] zu H-Einfang-Produkten durch Reduktion bzw. zu Olefinen durch Fragmentierung [5 J. Im Rahmen unserer Untersuchungen uber Demercurierungsreaktionen haben wir ausschlieBlich H-Einfangsprodukte isoliert.…”

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