The ADAPP trial: a two-year longitudinal multidisciplinary intervention study for prostate cancer frail patients on androgen deprivation associated to curative radiotherapy

Mareschal, Julie; Weber, Kerstin; Rigoli, P.; Biason, Edmund; Frambati, Laura; Gotteland, C.; Zilli, Thomas; Pichard, Claude; Miralbell, Raymond

doi:10.1080/0284186x.2016.1273545

Cited by 13 publications

(26 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This approach defines frailty as a clinical syndrome in which three or more of the following parameters are present: unintentional weight loss, self-reported psychophysical exhaustion, decreased grip strength, slow walking speed, and low physical activity [14,15]. This clinical syndrome closely overlaps with the known toxicities of ADT, and could therefore lead to the appearance of frailty in non-frail individuals, or accelerate the progression of frailty in individuals with an already established level of frailty [8,16,17].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy

Buigues

Navarro-Martínez

Sánchez-Martínez

et al. 2020

Cancers

View full text Add to dashboard Cite

Frailty syndrome is a functional state that includes a loss of ability to react to stressors, and is associated with poor outcomes, morbidity and premature mortality. The first line treatment in many men with prostate cancer (PCa) consists of an androgen-deprivation therapy (ADT) which can promote or favor frailty syndrome and ADT may therefore favor the progression of frailty over time. Among the pathophysiological bases of frailty, the presence of chronic low-grade inflammation has been associated with its adverse outcomes, but longitudinal studies are needed to validate these biomarkers. In this study, we prospectively evaluate frailty syndrome and blood inflammatory markers (IL1-beta, IL-6, IL-8, TNF alpha, C reactive protein) and leukocytes were measured at baseline and an average of 1 year later in PCa under ADT. Frailty was defined as having three or more of the following components: low lean mass, weakness, self-reported exhaustion, low activity level, and slow walking speed; prefrailty was defined as having one or two of those components. Multinomial regression analysis showed that among the inflammatory biomarkers, those significantly and repeatedly (baseline and follow-up time points) (p < 0.05) associated with frailty syndrome were high IL-6 levels and low lymphocyte counts in blood. Other biomarkers such as IL-8, monocyte counts and C reactive protein were significantly associated with frailty syndrome (p < 0.05) in cross-sectional analyses, but they do not predict frailty progression at 1 year-follow-up. Receiver operating characteristic curve analysis showed that both lymphocyte counts and IL-6 concentration significantly (p < 0.05) (although moderately) discriminate PCa patients that progressed in the severity of frailty syndrome. IL-6 and lymphocytes count are possible biomarkers, useful for identifying frail patients and predicting the progression of frailty in PCa under ADT. Our study suggests the use of these biomarkers to guide clinical decisions on prostate cancer treatment based on a multidisciplinary approach.

show abstract

Section: Introductionmentioning

confidence: 99%

Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy

Buigues

Navarro-Martínez

Sánchez-Martínez

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…Research relating to masculinity changes has found that many prostate cancer survivors seek to restore their masculinity through a focus on physical appearance and participating in activities that facilitate demonstration of control over their illness . Therefore, activities which promote body awareness and facilitate control, such as aerobic and resistance training, have become increasingly recognized for their established effect on improving body composition and physical function …”

Section: Introductionmentioning

confidence: 99%

“…6,15 To date, numerous randomized controlled trials (RCT) have attempted to capture and quantify masculinity, body image, and personal identity changes experienced by men with prostate cancer. 6,[16][17][18][19] Studies examining masculinity have often extrapolated their claims from quantitative assessments of erectile dysfunction, 20,21 levels of sexual activity, intimacy or function, 6,[15][16][17][18][22][23][24][25] or on perceptions of one's masculine self-esteem. 15 There thus exists significant heterogeneity across studies on what constitutes masculinity, and to date, most studies have quantitatively examined changes in masculinity in men receiving androgen deprivation therapy (ADT).…”

Section: Introductionmentioning

confidence: 99%

“…6,[16][17][18][19] Studies examining masculinity have often extrapolated their claims from quantitative assessments of erectile dysfunction, 20,21 levels of sexual activity, intimacy or function, 6,[15][16][17][18][22][23][24][25] or on perceptions of one's masculine self-esteem. 15 There thus exists significant heterogeneity across studies on what constitutes masculinity, and to date, most studies have quantitatively examined changes in masculinity in men receiving androgen deprivation therapy (ADT). 6,16,19 Additionally, the measurement tools currently used by psychosocial researchers have been designed to capture more "traditional" interpretations of masculinity and therefore may not account for sociocultural variations in how masculinity can be expressed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exercise interventions and their effect on masculinity, body image, and personal identity in prostate cancer—A systematic qualitative review

et al. 2019

View full text Add to dashboard Cite

Objective Men with prostate cancer face various body composition and psychosocial challenges following diagnosis. Movement‐based interventions such as exercise may represent novel strategies to improve these important biopsychosocial changes. This systematic qualitative review aimed to examine the various exercise interventions and their effect on male perception of masculinity, body image, and personal identity. Methods A systematic search across nine electronic databases was conducted in July 2017 and repeated in August 2018. Eligible studies included qualitative works examining masculinity, body image, or personal identity within an exercise intervention. Thematic content analysis allowed for qualitative synthesis across numerous studies. Results Six studies met eligibility criteria for inclusion. Four interventions used multimodal aerobic and resistance training, one incorporated aerobic exercise through football practice, and one utilized a home‐based aerobic plus yoga program. Exercise was implicated to improve masculinity through creation of a safe community, allowed for refocusing on valued male traits, provided a source of distraction, and offered a means of establishing control over one's illness. Exercise also facilitated a process of self‐reflection secondary to changes in physique and helped to re‐establish male self‐efficacy. Conclusions Regardless of prostate cancer stage, treatment status, or prior androgen deprivation therapy exposure, both aerobic or aerobic and resistance training exerted positive effects on perceived feelings of masculinity, body image, and personal identity.

show abstract

“…Two single-arm studies [101,102] and two RCTs [103*,104*] explored supportive, psychological or interpersonal counselling either in isolation or part of complex interventions. Four additional cross-sectional studies investigated relationships between use of psychosocial support services and psychological outcomes [105,106], treatment decision-making [107], and online community engagement [108].…”

Section: Insert Table 3 Here]mentioning

confidence: 99%

Psychological support for patients with cancer: evidence review and suggestions for future directions

Hulbert‐Williams

Beatty

Dhillon

2018

Current Opinion in Supportive &Amp; Palliative Care

View full text Add to dashboard Cite

Efficacious, timely and acceptable psychological interventions are a necessary component of comprehensive cancer care. There is some way to go before the evidence conclusively points towards which interventions work for which cancer groups and for which specific outcomes. Methodological limitations must be addressed in future trials; at the forefront remains the need for fully powered, head-to-head comparison trials.

show abstract

The ADAPP trial: a two-year longitudinal multidisciplinary intervention study for prostate cancer frail patients on androgen deprivation associated to curative radiotherapy

Abstract: The expected side effects of AD and RT were not observed in frail PC patients who followed this multidisciplinary care program.

Cited by 13 publications

References 27 publications

Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy

Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy

Exercise interventions and their effect on masculinity, body image, and personal identity in prostate cancer—A systematic qualitative review

Psychological support for patients with cancer: evidence review and suggestions for future directions

Contact Info

Product

Resources

About