The AD8

Galvin, James E.; Roe, Catherine M.; Powlishta, Kimberly K.; Coats, Mary A.; Muich, S. J.; Grant, Elizabeth; Miller, J. Philip; Storandt, Martha; Morris, John C.

doi:10.1212/01.wnl.0000172958.95282.2a

Cited by 895 publications

(502 citation statements)

References 35 publications

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“…In particular, the time expended on data acquisition is becoming an increasingly important factor in many health systems. Primarily because previous informantbased questionnaires on cognitive changes were deemed too time-consuming, Galvin et al (2005) developed the 8-item AD8, a brief informant interview to detect dementia. Here we demonstrate that the IQCODE can be reduced from 16 to 7 items with no loss in diagnostic accuracy, thereby obviating the concern expressed by Galvin et al regarding the length of the IQCODE.…”

Section: Discussionmentioning

confidence: 99%

Screening properties of the German IQCODE with a two-year time frame in MCI and early Alzheimer's disease

Ehrensperger

Berres

Taylor

et al. 2009

Int. Psychogeriatr.

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Background:The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) is a widely used screening tool for dementia. We aimed to determine the ability of the German version of the 16-item IQCODE with a two-year time frame to discriminate healthy mature control participants (NC) from mild cognitive impairment (MCI) and probable early Alzheimer's disease (AD) patients (all with Mini-mental State Examination (MMSE) scores ≥ 24/30) and to optimize diagnostic discriminability by shortening the IQCODE.

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Section: Discussionmentioning

confidence: 99%

Screening properties of the German IQCODE with a two-year time frame in MCI and early Alzheimer's disease

Ehrensperger

Berres

Taylor

et al. 2009

Int. Psychogeriatr.

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“…The participants self-completed the Alzheimer's Disease 8 (AD8) questionnaire for subjective cognitive impairment and were assessed with the MMSE for objective cognitive impairment by a neuropsychologist. 32,33 Participants with AD8 Ͼ2 or MMSE Ͻ26 were excluded. Eighty-one participants without subjective or objective cognitive impairment were selected for further genetic analysis, from which 12 APOE4 carriers, all 3/4 heterozygous, and 69 non-APOE4 carriers were found.…”

Section: Participantsmentioning

confidence: 99%

Effects of theApolipoprotein Eε4 Allele on Functional MRI duringn-Back Working Memory Tasks in Healthy Middle-Aged Adults

Chen¹,

Chen

et al. 2012

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:APOE4 is the best-documented genetic risk factor for sporadic AD. Previous research showed that APOE4 is associated with increased risk of occurrence and earlier onset of AD in a gene dose-dependent manner. However, the specific role of APOE4 in processing of brain functions requires further investigation. Investigators have used fMRI to measure brain activity on the basis of the blood oxygen level-dependent contrast. This study investigates the effects of APOE4 on fMRI during n-back WM tasks in healthy middle-aged adults.

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“…16 Relatives' report of memory deterioration also appears to accurately detect mild cognitive impairment even in the absence of measurable neuropsychological deficits. 8,[51][52][53] It is not clear that new neuropsychological subtypings of MCI lead to any increase in predictive ability. 54 There is growing evidence that signs and symptoms of vascular disease are important risks for dementia, and even for AD.…”

Section: Clinical Risk Factors For Development Of Dementia and Admentioning

confidence: 99%

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Fellows

Bergman²,

Wolfson³

et al. 2008

Can. j. neurol. sci.

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314As treatments to alleviate symptoms and to slow the progression of Alzheimer's disease (AD) emerge, an increasingly urgent dilemma for physicians is also developing: which of the many elderly individuals with memory complaints will develop Alzheimer's disease, and would therefore be candidates for preventive therapies? An important goal of current research must be to establish useful pre-clinical diagnostic and predictive guidelines, and this can only emerge from longitudinal follow-up of elderly individuals with mild memory loss. In this paper, we report the clinical characteristics of such a group, with the aim of ABSTRACT: Background: To determine whether clinical data obtained by history and physical examination can predict eventual progression to dementia in a cohort of elderly people with mild cognitive impairment. Methods: A prospective, longitudinal study of a cohort of elderly subjects with amnestic Mild Cognitive Impairment (MCI). Ninety subjects meeting the criteria for amnestic MCI were recruited and followed annually for an average of 3.3 years. Main outcome measure was the development of dementia determined by clinical assessment with confirmatory neuropsychological evaluation. Results: Fifty patients (56%) developed dementia on follow-up. They were older, had lower Mini-mental status exam (MMSE) scores and a shorter duration of symptoms at the time of first assessment. Multivariate logistic regression analysis identified age at symptom onset as the only clinical parameter which distinguished the group that deteriorated to dementia from the group that did not. The odds ratio for age was 1.1 (confidence interval 1.04 -1.18). Conclusions: Patients presenting with amnestic MCI insufficient for the diagnosis of dementia are at high risk of developing dementia on follow-up. In our cohort, 56% were diagnosed with dementia over an average period of 5.9 years from symptom onset. The only clinical predictor for the eventual development of dementia was older age at symptom onset. Clinical features alone were insufficient to predict development of dementia.RÉSUMÉ: Les données cliniques peuvent-elles prédire la progression vers la démence dans l'atteinte cognitive légère avec syndrome amnésique? Contexte : Le but de cette étude était de déterminer si les données cliniques provenant de l'histoire médicale et de l'examen physique peuvent prédire la progression éventuelle vers la démence dans une cohorte de gens âgés ayant une atteinte cognitive légère. Méthodes : Il s'agit d'une étude longitudinale prospective d'une cohorte de sujets âgés ayant une atteinte cognitive légère (ACL). Quatre-vingt-dix sujets rencontrant les critères diagnostiques de l'ACL amnésique ont été recrutés et suivis annuellement pendant 3,3 ans en moyenne. Le critère d'évaluation principal était l'apparition d'une démence selon l'évaluation clinique confirmée par une évaluation neuropsychologique. Résultats : Cinquante patients (56%) ont développé une démence au cours du suivi. Ils étaient plus âgés, avaient des scores MMSE plus bas et u...

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The AD8

Abstract: The AD8 is a brief, sensitive measure that reliably differentiates between nondemented and demented individuals. Use of the AD8 in conjunction with a brief assessment of the participant could improve diagnostic accuracy in general practice.

Cited by 895 publications

References 35 publications

Screening properties of the German IQCODE with a two-year time frame in MCI and early Alzheimer's disease

Screening properties of the German IQCODE with a two-year time frame in MCI and early Alzheimer's disease

Effects of theApolipoprotein Eε4 Allele on Functional MRI duringn-Back Working Memory Tasks in Healthy Middle-Aged Adults

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

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