The acyl-CoA synthetase
Tg
ACS1 allows neutral lipid metabolism and extracellular motility in
Toxoplasma gondii
through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions
Sarah Charital,
Serena Shunmugam,
Sheena Dass
et al.
Abstract:Apicomplexa parasites cause major diseases such as toxoplasmosis and malaria that have major health and economic burdens. These unicellular pathogens are obligate intracellular parasites that heavily depend on lipid metabolism for the survival within their hosts. Their lipid synthesis relies on an essential combination of fatty acids (FAs) obtained from both
de novo
synthesis and scavenging from the host. The constant flux of scavenged FA needs to be channeled toward parasite lipid … Show more
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