The ACVD task force on canine atopic dermatitis (II): genetic factors

Sousa, Candace A.; Marsella, Rosanna

doi:10.1016/s0165-2427(01)00297-5

Cited by 58 publications

(51 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of these studies, performed in Sweden on a cohort of children followed until the age of four years, showed that those from families with a history of allergies exposed to second-hand tobacco during their first year of life were much more likely to develop an allergy than children without such a family background exposed to second-hand smoke. In dogs, the hereditary risk of atopic dermatitis depends on breed and lineage (Sousa and Marsella, 2001). Consistently, the proportion of dogs from predisposed breeds was higher in the allergic group than in the control group in this study, although the difference was not significant.…”

Section: Tablesupporting

confidence: 65%

Association between passive smoking and atopic dermatitis in dogs

Marignac

Desquilbet

et al. 2014

Food and Chemical Toxicology

View full text Add to dashboard Cite

Section: Tablesupporting

confidence: 65%

Association between passive smoking and atopic dermatitis in dogs

Marignac

Desquilbet

et al. 2014

Food and Chemical Toxicology

View full text Add to dashboard Cite

“…5,6 Furthermore, genetic inheritance of AD was also reported in both species. 7 It is important to validate whether skin barrier impairment caused by a FLG gene mutation is associated with cAD, as shown in human AD.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Canine Filaggrin: Gene Structure and Protein Expression in Dog Skin

Kanda¹,

Sasaki²,

Shiohama³

et al. 2013

Advances in Veterinary Dermatology

View full text Add to dashboard Cite

Background -Filaggrin (FLG) is a key protein for skin barrier formation and hydration of the stratum corneum. In humans, a strong association between FLG gene mutations and atopic dermatitis has been reported. Although similar pathogenesis and clinical manifestation have been argued in canine atopic dermatitis, our understanding of canine FLG is limited.Hypothesis ⁄ Objectives -The aim of this study was to determine the structure of the canine FLG gene and to raise anti-dog FLG antibodies, which will be useful to detect FLG protein in dog skin.Methods -The structure of the canine FLG gene was determined by analysing the publicly available canine genome DNA sequence. Polyclonal anti-dog FLG antibodies were raised based on the canine FLG sequence analysis and used for defining the FLG expression pattern in dog skin by western blotting and immunohistochemistry.Results -Genomic DNA sequence analysis revealed that canine FLG contained four units of repeated sequences corresponding to FLG monomer protein. Western blots probed with anti-dog FLG monomer detected two bands at 59 and 54 kDa, which were estimated sizes. The results of immunohistochemistry showed that canine FLG was expressed in the stratum granulosum of the epidermis as a granular staining pattern in the cytoplasmic region.Conclusions and clinical importance -This study revealed the unique gene structure of canine FLG that results in production of FLG monomers larger than those of humans or mice. The anti-dog FLG antibodies raised in this study identified FLG in dog skin. These antibodies will enable us to screen FLG-deficient dogs with canine atopic dermatitis or ichthyosis.

show abstract

“…House dust mite allergen, which is the most common environmental allergen in humans, has been identified as the most important allergen in canine AD [17]. It has been speculated that a predisposing genetic factor may exist in dogs with AD, since there is a high incidence of the disease in certain breeds and families [28]. Histopathological analysis revealed that CD4 + cells were markedly infil-trated in lesional skin of canine AD [26].…”

mentioning

confidence: 99%

Expression Analysis of CCL27 and CCL28 mRNA in Lesional and Non-Lesional Skin of Dogs with Atopic Dermatitis

Maeda

Tsuchida

Shibata

et al. 2008

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Chemokines are important regulators of the selective recruitment of inflammatory cells into sites of allergic inflammation. Since canine atopic dermatitis (AD) shares many clinical features of human AD, patterns of chemokine production in dogs may also be similar with those in humans. The aim of this study was to examine mRNA expression of CCL27 and CCL28 in lesional skin of dogs with AD to demonstrate similarity of chemokine production with human counterparts. RNA was extracted from skin biopsy specimens of 12 dogs with AD. The mRNA expression of CC chemokines (CCL4, CCL19, CCL20, CCL21, CCL24, CCL27 and CCL28) was analyzed by quantitative real-time PCR and was compared between lesional and non-lesional skin. Seven types of chemokines examined were constitutively expressed in both lesional and non-lesional skin. It was found that mRNA expression levels of CCL27 and CCL28 among the chemokines were significantly different between lesional and non-lesional skin (P<0.05). Expression level of CCL27 mRNA in lesional skin was significantly lower than that in non-lesional skin. On the other hand, CCL28 mRNA expression in lesional skin was found to be higher than that in non-lesional skin. These results suggest that CCL28 but not CCL27 may play important roles in immunopathogenesis of canine AD, indicating that experimental canine study may provide additional information that can be extrapolated to human AD.

show abstract

The ACVD task force on canine atopic dermatitis (II): genetic factors

Cited by 58 publications

References 6 publications

Association between passive smoking and atopic dermatitis in dogs

Association between passive smoking and atopic dermatitis in dogs

Characterization of Canine Filaggrin: Gene Structure and Protein Expression in Dog Skin

Expression Analysis of CCL27 and CCL28 mRNA in Lesional and Non-Lesional Skin of Dogs with Atopic Dermatitis

Contact Info

Product

Resources

About