The acute toxicity of the metaldehyde on the climbing perch

Ismail, Syamimi Wahida; Dahalan, Farrah Aini; Zakaria, A.; Shakaff, Ali Yeon Mad; Ahmad, Siti Aqlima; Shukor, Mohd Yunus; Sabullah, Mohd Khalizan; Khalil, Khalilah Abdul; Jalil, Mohd Faizal Ab

doi:10.1051/e3sconf/20183402031

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…Los artrópodos y gusanos de tierra parece que no se ven afectados por el metaldehído (Edwards et al, 2009;Rumbeiha 2014). Hay información contradictoria sobre la toxicidad en organismos acuáticos, hay estudios que indican que estos no se ven afectados mientras que otros dicen que la concentración letal media a las 96 h para la mojarra azul es de 10 ppb y para la trucha es de 62 ppb (Bieri, 2003;Ismail et al, 2018). En aves la dosis letal de metaldehído es 500 mg/kg de peso vivo (Rumbeiha, 2014;Saad et al, 2017).…”

Section: Toxicidad Del Metaldehídounclassified

Intoxicación Secundaria Por Metaldehído en Un Tejón (Meles Meles): Estudio Experimental Con Helix Aspersa

Panales,

Navas Ruíz,

María-Mojica

et al. 2024

An. Vet. Murcia

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Metaldehyde is a compound with molluscicidal activity, widely used to control snails and slugs, although its inappropriate use can cause poisoning in other species, which are not the target ones. Faced with the death of a badger (Meles meles), the hypothesis of a possible secondary poisoning by ingestion of snails killed by the pesticide was considered. The objective of this work was to design an experimental study that would bring light on this question in the investigation of the cause of death of the badger. Two experiments were designed with the species Helix aspersa, one to evaluate if the lethality is dose-dependent and another to evaluate the latency time from the molluscicidal treatment. In the dose experiment, five groups of snails were made, called "Superior", "High", "Medium", "Low" and "Lower", to which 400, 200, 133.3, 66.7 and 40 μg of metaldehyde per snail, respectively. After the experiment, the analysis of metaldehyde present per snail in each of the groups was as follows: "Higher" 137.4 μg, "High" 69.93 μg, "Medium" 47.24 μg, "Low" 31.72 μg and "Lower" 6.05 μg. In the time test, 400 μg per snail was applied and the snails of each batch were sacrificed at the following times: T0, T60, T120 and 240 minutes. Those of the last batch died at 270 minutes (before sacrifice). The mean amounts per snail of each lot were the following: T0min 352.68 μg, T60min 277.41 μg, T120min 206.18 μg, T240min 164.8 μg and T270min 90.2 μg of metaldehyde. After calculations based on the mean lethal dose of mice, it was estimated that, despite the fact that traces of metaldehyde were found in the organism of the snails, it is unlikely that secondary poisoning could occur in a badger due to the consumption of snails intoxicated with metaldehyde. El metaldehído es un compuesto con actividad molusquicida, ampliamente utilizado para el control de caracoles y babosas, aunque su uso inadecuado puede causar intoxicaciones en otras especies no diana. Ante la muerte de un tejón (Meles meles), se barajó la hipótesis de una posible intoxicación secundaria por ingestión de caracoles muertos por el plaguicida. El presente trabajo tenía por objetivo diseñar un estudio experimental que permitiera arrojar luz sobre esta cuestión en la investigación de la causa de muerte del tejón. Se diseñaron dos experimentos con la especie Helix aspersa, uno para evaluar si la letalidad es dosis-dependiente y otro para evaluar el tiempo de latencia desde el tratamiento molusquicida. En el experimento de dosis se hicieron cinco grupos de caracoles, denominados “Superior”, “Alta”, “Media”, “Baja” e “Inferior”, a los que se les administró 400, 200, 133.3, 66.7 y 40 μg de metaldehído por caracol, respectivamente. Tras el experimento, los análisis de metaldehído presente por caracol en cada uno de los grupos fue el siguiente: “Superior” 137.4 μg, “Alta” 69.93 μg, “Media” 47.24 μg, “Baja” 31.72 μg e “Inferior” 6.05 μg. En el ensayo de tiempos se aplicaron 400 μg por caracol y se sacrificaron los caracoles de cada lote a los siguientes tiempos: T0, T60, T120 y 240 minutos. Los del último lote murieron a los 270 minutos (antes del sacrificio). Las cantidades medias por caracol de cada lote fueron las siguientes: T0min 352.68 μg, T60min 277.41 μg, T120min 206.18 μg, T240min 164.8 μg y T270min 90.2 μg de metaldehído. Tras los cálculos basados en la dosis letal media de ratón se estimó que, a pesar de que se encontraran restos de metaldehído en el organismo de los caracoles, es improbable que se pueda dar una intoxicación secundaria en un tejón por el consumo de caracoles intoxicados con metaldehído.

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Section: Toxicidad Del Metaldehídounclassified

Intoxicación Secundaria Por Metaldehído en Un Tejón (Meles Meles): Estudio Experimental Con Helix Aspersa

Panales,

Navas Ruíz,

María-Mojica

et al. 2024

An. Vet. Murcia

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“…Climbing perch, Anabas testudineus inhabits in crop fields and irrigation systems, and is well known for its high tolerance and survival level in extreme environmental conditions (Ismail et al, 2018). It is a commercially important fish with good nutritive value.…”

Section: Introductionmentioning

confidence: 99%

Environmentally relevant lead alters nuclear integrity in erythrocytes and generates oxidative stress in liver of Anabas testudineus: Involvement of Nrf2‐Keap1 regulation and expression of biomarker genes

Dey,

Mondal,

Chattopadhyay

2023

J of Applied Toxicology

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Genotoxic and hepatotoxic effects of lead (Pb) on a freshwater fish, climbing perch (Anabas testudineus) were studied at an environmentally relevant concentration (43.3 ppm). The genotoxic potential of Pb was confirmed by micronucleus study, with increased frequencies of erythrocytic nuclear alterations like lobed, blebbed, notched, fragmented, and micronuclei were observed in erythrocytes in treated groups as compared to control. Inorganic Pb induces oxidative stress which is a consequence of elevated level of Reactive Oxygen Species. Hepatotoxicity was assessed both by the oxidative stress and cellular responses that emerged due to the toxic assault of Pb in the liver, the most important detoxifying organ. Upregulation of xenobiotic metabolizing enzyme like catalase was evident after 15, 30, and 90 days of exposure, and a profound effect was observed on 30th days. The level of lipid peroxidation and reduced glutathione was increased after Pb exposure. Histoarchitectural damages of liver were distinctly evident in treated fish. Western blot analysis confirmed the expressional alterations of stress‐responsive marker proteins like Nrf2, Keap1, Hsp70, and Nqo1. Pb exposure resulted in increased expression of Hsp70, Nrf2, and Nqo1, whereas Keap1 was downregulated, suggesting the involvement of Nrf2‐Keap1 regulation as a cytoprotective mechanism against Pb toxicity.

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Behavioural toxicity and respiratory distress in early life and adult stage of walking catfish Clarias batrachus (Linnaeus) under acute fluoride exposures

Dhara

Saha²,

Chukwuka³

et al. 2021

Toxicol. Environ. Health Sci.

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The acute toxicity of the metaldehyde on the climbing perch

Cited by 5 publications

References 19 publications

Intoxicación Secundaria Por Metaldehído en Un Tejón (Meles Meles): Estudio Experimental Con Helix Aspersa

Intoxicación Secundaria Por Metaldehído en Un Tejón (Meles Meles): Estudio Experimental Con Helix Aspersa

Environmentally relevant lead alters nuclear integrity in erythrocytes and generates oxidative stress in liver of Anabas testudineus: Involvement of Nrf2‐Keap1 regulation and expression of biomarker genes

Behavioural toxicity and respiratory distress in early life and adult stage of walking catfish Clarias batrachus (Linnaeus) under acute fluoride exposures

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