The acute effects of fine particles on respiratory mortality and morbidity in Beijing, 2004–2009

Li, Pei; Xin, Jinyuan; Wang, Yuesi; Wang, Shigong; Li, Guoxing; Pan, Xiaochuan; Liu, Zirui

doi:10.1007/s11356-013-1688-8

Cited by 126 publications

(73 citation statements)

References 52 publications

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“…Epidemiological studies have demonstrated that PM 2.5 exposure correlates with increased incidence of respiratory diseases (18,19). Short-term exposure to PM 2.5 has been reported as associated with acute airway inflammation (20).…”

Section: Discussionmentioning

confidence: 99%

Tubeimoside I attenuates inflammation and oxidative damage in a mice model of PM2.5‑induced pulmonary injury

Zhang

et al. 2017

Exp Ther Med

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Abstract. In the present study, the effects of tubeimoside I (TBMS1) on particulate matter <2.5 µm in diameter (PM 2.5 )-induced pulmonary injury and its mechanisms of action were investigated. Male BALB/c mice were randomly assigned into five groups (n=10/group): Control, PM 2.5 , PM 2.5 + TBMS1 45 mg/kg, PM 2.5 + TBMS1 90 mg/kg and PM 2.5 + TBMS1 180 mg/kg. The dose of the PM 2.5 suspension administered to the mice was 40 mg/kg via nasal instillation. The PM 2.5 + TBMS1 groups received TBMS1 daily orally for 21 consecutive days, while the mice in the control and PM 2.5 groups received equivalent volumes of PBS. Subsequently, lactic dehydrogenase, acid phosphatase, alkaline phosphatase, albumin, tumor necrosis factor-α and interleukin-6 protein levels in bronchoalveolar lavage fluid were determined. Oxidative stress was evaluated by detecting the protein levels of malondialdehyde, superoxide dismutase and inducible nitric oxide synthase, and the level of nitric oxide in lung tissue. Lastly, histopathological images of lung sections were obtained to observe changes in the lung tissue with treatment. The results indicated that exposure to PM 2.5 induced pathological pulmonary changes, and biofilm and parenchymal cell damage, and promoted inflammation and oxidative stress. Treatment with TBMS1 attenuated the development of PM 2.5 -induced pulmonary injury. Its mechanisms of action were associated with reducing cytotoxic effects, levels of inflammatory mediators and oxidative damage. In conclusion, the results of the present study indicate that TBMS1 is a potential therapeutic drug for treating PM 2.5 -induced pulmonary injury.

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Section: Discussionmentioning

confidence: 99%

Tubeimoside I attenuates inflammation and oxidative damage in a mice model of PM2.5‑induced pulmonary injury

Zhang

et al. 2017

Exp Ther Med

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“…Among those concerns is exposure to inhalable particulate matter (PM). In recent years, scientific attention has focused mostly on fine fraction of particles (<2.5 μm in diameter; i.e., PM2.5; Brunekreef et al 2009;Hoek et al 2013;Li et al 2013;Polichetti et al 2009) that has been linked to both acute and chronic respiratory and cardiopulmonary health effects including lung cancer (Mitchell et al 2007;Valavanidis et al 2008). Additional focus has been placed on determining associations with PM components (elemental carbon, sulfates, nitrates, polycyclic aromatic hydrocarbons, and biological components; Atkinson et al 2010;Brunekreef et al 2009;Gent et al 2009;Nemmar et al 2013;Maynard et al 2007;Sarnat et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Trace metals in size-fractionated particulate matter in a Portuguese hospital: exposure risks assessment and comparisons with other countries

Slezáková

Morais

Pereira

2013

Environ Sci Pollut Res

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Hospitals are considered as a special and important type of indoor public place where air quality has significant impacts on potential health outcomes. Information on indoor air quality of these environments, concerning exposures to partic-ulate matter (PM) and related toxicity, is limited though. This work aims to evaluate risks associated with inhalation exposure to ten toxic metals and chlorine (As, Ni, Cr, Cd, Pb, Mn, Se, Ba, Al, Si, and Cl) in coarse (PM2.5-10) and fine (PM2.5) particles in a Portuguese hospital in comparison with studies representative of other countries. Samples were collected during 1 month in one urban hospital; elemental PM characterization was determined by proton-induced X-ray emission. Noncarcinogenic and carcinogenic risks were assessed according to the methodology provided by the United States Environmental Protection Agency (USEPA; Region III Risk-Based Concentration Table) for three different age categories of hospital personnel (adults, >20, and <65 years) and patients (considering nine different age groups, i.e., children of 1-3 years to seniors of >65 years). The estimated noncarcinogenic risks due to occupational inhalation exposure to PM2.5-bound metals ranged from 5.88×10−6 for Se (adults, 55-64 years) to 9.35×10 −1 for As (adults, 20-24 years) with total noncarcinogenic risks (sum of all metals) above the safe level for all three age categories. As and Cl (the latter due to its high abundances) were the most important contributors (approximately 90 %) to noncarcinogenic risks. For PM2.5-10, noncarcinogenic risks of all metals were acceptable to all age groups. Concerning carcinogenic risks, for Ni and Pb, they were negligible (<1×10 −6 ) in both PM fractions for all age groups of hospital personnel; potential risks were observed for As and Cr with values in PM2.5 exceeding (up to 62 and 5 times, respectively) USEPA guideline across all age groups; for PM2.5-10, increased excess risks of As and Cr were observed particularly for long-term exposures (adults, 55-64 years). Total carcinogenic risks highly (up to 67 times) exceeded the recommended level for all age groups, thus clearly showing that occupational exposure to metals in fine particles pose significant risks. If the extensive working hours of hospital medical staff were considered, the respective noncarcinogenic and carcinogenic risks were increased, the latter for PM2.5 exceeding the USEPA cumulative guideline of 10 . For adult patients, the estimated noncarcinogenic and carcinogenic risks were approximately three times higher than for personnel, with particular concerns observed for children and adolescents.

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“…Fugitive dust generated by wind erosion can contribute a significant amount of suspended particles less than 10 μm in aerodynamic diameter (PM 10 ) as well as particles less than 2.5 μm in aerodynamic diameter (PM 2.5 ), which have been shown to have negative health effects (Li et al, 2013;Sawyer et al, 2010). The negative health effects may come about directly when inhaled as well as indirectly through events such as deposition and reduced visibility.…”

Section: Air Quality Regulations Affecting Dod Installationsmentioning

confidence: 99%

Fugitive Dust Emissions from Off-Road Vehicle Maneuvers on Military Training Lands

Meeks

Wagner²,

Maghirang

et al. 2015

Trans. ASABE

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Military installations in the United States may be large sources of fugitive dust emissions.Off-road vehicle training can contribute to air quality degradation resulting from increased wind erosion events as a result of soil disruption; however, limited information exists regarding the impacts of off-road vehicle maneuvering. This study was conducted to determine the effects of soil texture and intensity of training with off-road vehicles on fugitive dust emission potential due to wind erosion at military training installations.Multi-pass trafficking experiments, involving wheeled and tracked military vehicles (i.e., M1A1 Abrams tank, M925A1 water tanker and various HMMWV models), were conducted at three military training facilities with different climate and soil texture (i.e., Fort Riley, KS; Fort Benning, GA; and Yakima Training Center, WA). Dust emissions were measured on site using a Portable In-Situ Wind Erosion Laboratory (PI-SWERL) coupled with a DustTrak™ dust monitor. In addition, a top layer of soil was collected in trays and tested in a laboratory wind tunnel for dust emission potential. In wind tunnel testing, the amount of emitted dust was measured using glass-fiber filters through high-volume samplers. Also, the particle size distribution and concentration of the emitted dust were measured using a GRIMM aerosol spectrometer.Comparison of the PI-SWERL (with DustTrak™ dust monitor) and wind tunnel test (with GRIMM aerosol spectrometer) results showed significant difference and little correlation. Also, comparison of the filter and GRIMM aerosol spectrometer data showed significant difference but high correlation. The dust emission potential (as measured with the GRIMM spectrometer) was significantly influenced by soil texture, vehicle type and number of passes. (1,369%) and 4,023 mg m -2 (5,276%) for 10 and 20 passes, respectively. Soil texture also played an important role in dust emission potential. For all treatment effects, there was a 1,369% difference in emissions between silty clay loam soil and loamy sand soil.iv

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The acute effects of fine particles on respiratory mortality and morbidity in Beijing, 2004–2009

Cited by 126 publications

References 52 publications

Tubeimoside I attenuates inflammation and oxidative damage in a mice model of PM2.5‑induced pulmonary injury

Tubeimoside I attenuates inflammation and oxidative damage in a mice model of PM2.5‑induced pulmonary injury

Trace metals in size-fractionated particulate matter in a Portuguese hospital: exposure risks assessment and comparisons with other countries

Fugitive Dust Emissions from Off-Road Vehicle Maneuvers on Military Training Lands

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