The acute effects of 3,4-methylenedioxymethamphetamine and d-methamphetamine on human cognitive functioning

Abstract

Further research into the acute effects of amphetamine preparations is necessary to further quantify the acute disruption of aspects of human functioning crucial to complex activities such as attention, selective memory, and psychomotor performance.

Repeated Acquisition in the Morris Swim Task: Effects of Methylenedioxymethamphetamine, Methamphetamine, and Methylphenidate

“…In particular, use of both MDMA and MA has been associated with neurotoxicity and clinical studies have raised the possibility of adverse effects on cognition, learning and memory (e.g., Baicy & London, 2007; Homer, et al, 2008; McCann, et al, 2008; Nulsen, et al, 2010; Scott, et al, 2007; Stough, et al, 2012). In contrast however, some stimulant drugs are used to improve cognitive functioning in disorders such as ADHD and have been shown to produce cognitive enhancement following acute administration to healthy humans in laboratory settings (Barch & Carter, 2005; Hart et al, 2008; Kirkpatrick et al, 2012).…”

Cognitive functioning associated with acute and subacute effects of classic psychedelics and MDMA - a systematic review and meta-analysis

“…Thirteen studies ( n = 240) 125 , 127 , 129 , 130 , 135 , 137 , 140 , 141 , 144 , 150 – 153 investigated the effects of acute MDMA exposure on executive functioning, utilizing 14 different tasks. The majority of these studies 125 , 127 , 129 , 130 , 135 , 137 , 144 , 150 – 153 showed no significant effect of MDMA on fourteen tasks, while four studies 130 , 140 , 141 , 152 reported impaired performance across four tasks.…”

“…Thirteen studies ( n = 270) 21 , 124 , 125 , 127 , 128 , 133 , 135 , 141 , 144 , 147 , 153 – 155 assessed the effects of MDMA on attention using 18 different tests. The majority of these studies 21 , 124 , 125 , 127 , 128 , 133 , 141 , 144 , 147 , 153 – 155 found no effect of MDMA on attentional performance across 17 measures, while four studies 125 , 135 , 141 , 153 reported impaired attention in four tasks.…”

Applied human psychopharmacology: the practical psychobiological consequences of some novel and ancient psychoactive drugs

“…They assessed the effects of an acute dose of methamphetamine on car driving skills in a laboratory simulator (Stough et al , ). In previous studies, they have found deficits with MDMA and amphetamine, and these latest findings are part of an ongoing series (Stough et al , , ; Silber et al , ). The social drug nicotine has mild stimulant properties, but a complex and multi‐factorial relationship with stress.…”