The acute effect of moderate intensity aquatic exercise on coagulation factors in haemophiliacs

Abstract

The objective of this cross-sectional study was to analyse the acute effect of aquatic exercise on haemostasis in persons with haemophilia. Ten adult haemophiliacs (8 type A, 2 type B) familiarized with aquatic training performed a 20-min exercise session in a swimming pool at an intensity of ~70% maximum heart rate (HR). Blood samples were collected immediately after the training session. The haemostatic parameters selected for analyses were factor VIII (FVIII), prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen. There were unclear effects of the exercise bout on FVIII and APTT, with a possibly beneficial effect on PT (-11·4%; 90% confidence interval: -26·1;3·3%), and a trivial change on fibrinogen levels. It was found an association between the mean rise in HR during exercise and the decrement in PT after exercise (r = 0·729; P = 0·026). The greater changes were observed in the patients diagnosed with a moderate level of haemophilia. It is concluded that a short bout of moderate intensity of aquatic exercise may have a positive influence on PT in adults with haemophilia with greater changes in those individuals exhibiting a greater rise in HR during exercise. This may be an important issue to the haemostatic control of haemophiliacs in clinical settings. Further studies are warranted for testing the influence of different aquatic exercise intensities on haemostasis.

Effect of moderate intensity exercise on haemostatic capacity in adults with haemophilia A and B: pilot study

“…In this study, we detected a pro-haemostatic response 5 min after moderate intensity exercise, and a reversal of these changes at 60 min in men with HA with baseline factor deficiencies of ≤10%. These findings are in keeping with other published studies [2,[4][5][6][7][8][9][10]. However, for the first time, we describe a sustainable increase in VWF:Ag and FVIII in men with HB, in contrast to men with HA.…”

Impact of aerobic exercise on haemostatic indices in paediatric patients with haemophilia

“…Dynamic, isokinetic and isometric exercises are associated with improved muscle strength, proprioception and joint health, in addition to increasing social inclusion and adaptation (8)(9)(10). Additionally, studies in PWH have suggested a possible improvement in coagulation parameters including FVIII:C and von Willebrand factor (VWF) with exercise, suggesting that appropriate exercise, to a certain extent, might diminish the risk of bleeding (11)(12)(13). These studies, however, typically investigated small cohorts of subjects performing sub-maximal exercise; additionally, they did not use global haemostatic assays to assess coagulation.…”

Comparison of platelet‐derived and plasma factor VIII efficacy using a novel native whole blood thrombin generation assay

“…FVIII levels , or aggressive behavior of some animals. Evidence suggests that coagulation factors, including FVIII and VWF, significantly change after exercise . To demonstrate potential clinical usefulness, analyzes of blood from a healthy human control showed that, with the exception of the inter‐assay variation of the TGR, both intra‐assay and inter‐assay coefficients of variation of all TG parameters were < 15% (data not shown).…”