The acute effect of a moderate intensity ergocycle exercise on the coagulation parameters in type 2 diabetes mellitus patients: a feasibility study

Abstract

Background. Type 2 diabetes mellitus (T2DM) patients experience higher atherothrombotic risks that could lead to cardiovascular diseases, due to increases in coagulation activities. The role of exercise in altering coagulation activities among T2DM patients is still inconclusive. This feasibility study aimed to evaluate the immediate effect of a moderate intensity ergocycle exercise, primary on the coagulation parameters and secondary on the systemic inflammation and blood glucose, in otherwise healthy T2DM patients. Methods. Ten T2DM patients (64 ± 7 year, 40% female) performed a 30-minute moderate-intensity ergocycle exercise at 50-60% of heart rate reserved. Coagulation parameters (activated partial thromboplastin time [aPTT], prothrombin time [PT] and platelet count), erythrocyte sedimentation rate, and blood glucose were assessed before the exercise (T0), immediately after the exercise (T1), and 30 minutes post exercise (T2). One-way repeated measured ANOVA was used to assess the outcomes over time. Results. All participants completed and adhered to the exercise protocol. There were increases in aPTT and PT but decreases in platelet count at T1 and T2 compared to at T0 (P < 0.05), indicating reduction in the coagula-tion activities. Those values, however, were still within normal ranges. The erythrocyte sedimentation rates were unaffected, while blood glucose decreased from 202 ± 35 mg/dL at T0 to 173 ± 33 mg/dL and 158 ± 30 mg/dL at T1 and T2 (P < 0.01). Conclusion. The 30-minute moderate-intensity ergocycle decreases coagulation activities and blood glucose but does not affect erythrocyte sedimentation rates in T2DM patients. Future studies should focus on the chronic adaptation of the coagulation parameters after ergocycle training among a T2DM patients with coagulation impairments.

The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model

“…These results demonstrate the negative impact of endometriosis on the inflammatory and coagulation systems. Previous evidence reported higher coagulation status in endometriosis and other diseases, which is similar to the present study findings 1 , 8 , 9 , 36 . Therefore, it appears that therapeutic interventions that modulate these coagulation factors and their dependent pathways can improve endometriosis.…”

“…These conflicting results support the idea that the influence of exercise training on the coagulation system is correlated with the exercise mode, duration, and intensity as well as types of medical conditions [36] . Also, there may be an overlap between genotype and phenotypic characteristics so that genetic causes somatic traits which may introduce new pathways in the molecular aspects of endometriosis 61 , 62 , 63 and may cause even different adaptations or responses to exercise training.…”

The correlates of physical activity during COVID-19 pandemic among Indonesian young adults

“…[ 16 ] In addition, it also reduces cortisol, a stress hormone that can suppress immune cell function,[ 18 ] improves metabolic parameters,[ 19 ] improves bioenergetics,[ 20 ] and reduces systemic inflammations. [ 21 22 ] All of which play an important role in boosting the immune system[ 23 ] which further plays significant roles in controlling COVID-19 transmission. Moreover, individuals who were consistently meeting physical activity recommendations experience reduced risks for severe COVID-19 complications when they are infected with the coronavirus,[ 24 ] which is associated with an increase in quality of life.…”

Physical Activity and Post-COVID-19 Syndrome in Older Adults: A Systematic Review

“…Physical activity might also prevent the risk of COVID-19 complications and sequelae and improve patients' quality of life. Regular physical activity reduces systemic inflammations (Arovah & Kushartanti, 2020), improves metabolic profiles (Arovah & Heesch, 2021;Arovah & Kushartanti, 2019) and glycaemic control (Ferreira et al, 2021), which optimizes the immune system (Zheng et al, 2015), thus playing important roles in preventing and managing COVID-19 and post-COVID-19 symptoms.…”