The Activity of Malignant Tumours and Response to Therapeutic Agents, Studied by Continuous Records of Radioactive Phosphorus Uptake

Bullen, M. A.; Freundlich, H.; Hale, Brendan; Marshall, D. H.; Tudway, R. C.

doi:10.1136/pgmj.39.451.265

Cited by 30 publications

(7 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This count-rate is presumed to run parallel to the metabolic activity of the growth. As previously reported in other types of case (Bullen et al 1963) a period of quiescence folloWed by 'peaking' of activity is induced, by the giving of methotrexate, or a similar agent for a few days. Deep X-ray therapy is then administered to the growth at the time of the peaks.…”

supporting

confidence: 63%

Radioisotopes in the Investigation of Tumours [Abridged]

1964

Proceedings of the Royal Society of Medicine

View full text Add to dashboard Cite

A method is described of controlling the activity of undifferentiated cerebral gliomata, within restricted limits, by means of chemotherapy, and then attempting to use this control to potentiate the effectiveness of deep X-ray therapy.In the first instance, a miniature geiger counter of type B. .N. is implanted into the tumour by a neurosurgeon. This is usually done at the time of the biopsy. The instrument is 3 mm in diameter and is under 6 cm long. No trouble has been experienced with sepsis or the presence of the counter in the brain over periods of a few weeks.The cases chosen are those for whom there is no effective alternative treatment, and whose brain damage is not already too severe.After insertion of the counter a dose of tracer radioactive phosphorus is given and a continuous record is made of the count-ra-te during the whole procedure. This count-rate is presumed to run parallel to the metabolic activity of the growth. As previously reported in other types of case (Bullen et al. 1963) a period of quiescence folloWed by 'peaking' of activity is induced, by the giving of methotrexate, or a similar agent for a few days. Deep X-ray therapy is then administered to the growth at the time of the peaks.So far, work has been limited to the gaining of experience in the application of the method. We have not tried sufficient brain tumour cases even to have definite impressions of the clinical results. Out of the first 8 cases, 4 were inconclusive from the beginning. Three were very advanced and the patients died in a few days, before deep X-ray therapy began; in another the geiger failed. Of the 4 cases in which treatment was concluded, 2 died within three months and 2 are well at the end of that time.The tracings of radiophosphorus uptake from each of the four completely treated cases were shown and clinical details were given. It is possible that similar immediate results would have been seen from orthodox deep X-ray routines alone, but it appears essential to carry this research to a conclusion, because a useful potentiation of sensitivity of the growth would enable us to evade the dangerous effects of high doses of radiation on the normal brain tissue; in addition, improvements in the local treatment of advanced and inoperable gliomata will be doubly valuable because distant metastases do not occur.

show abstract

supporting

confidence: 63%

Radioisotopes in the Investigation of Tumours [Abridged]

1964

Proceedings of the Royal Society of Medicine

View full text Add to dashboard Cite

show abstract

“…The hormone-independent malignant tumour did not show such a diurnal variation in 32p uptake. Clinical observations have previously suggested that the diurnal variation in 32p uptake was chiefly restricted to hormone-dependent tumours (Bullen et al, 1963). This suggestion now finds support from animal experiments.…”

Section: Dark Periodmentioning

confidence: 72%

“…In human breast cancer it has been difficult to find a periodicity in the uptake of 32p (Bullen et al, 1963;Calcutt et al, 1967;Taylor et al, 1968) partly due to technical difficulties, but Stoll and Burch (1968) found a circadian rhythm in the late 32p uptake in 9 out of 19 patients with mammary carcinoma. The temperature variations in the adjacent skin followed the 32p curve, both curves having low diurnal and high nocturnal levels.…”

Section: Dark Periodmentioning

confidence: 99%

“…SOME years ago there was a great interest for the circadian variations in 32p uptake in human breast cancer (Bullen et al, 1963;Calcutt et at., 1967;Stoll and Burch, 1968;Taylor et al, 1968;Woolley-Hart et al, 1968). In this connection the word " uptake " is taken to mean the changes in measured radioactivity from 32p in the tissue once equilibrium is established.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Circadian variations in 32P uptake of a DMBA-induced mammary tumour and Walker carcinosarcoma in rats

Møoller¹,

Bojsen²

1976

Br J Cancer

View full text Add to dashboard Cite

Summary.-The 32p uptake in a mammary tumour induced by DMBA and in the Walker 256 carcinosarcoma was measured by external GM-tubes. The uptake was significantly higher than in the skin. During exposure to a synchronized light regime a circadian variation was present in the 32p uptake of the hormonedependent DMBA-induced tumour. The maximal 32p uptake was in the dark period, in which the highest temperature in the tumour has also been found (M0ller and Bojsen, 1975). In the hormone-independent Walker 256 carcinosarcoma there was no periodicity in 32p uptake. No variation in 32p uptake was registered in the skin of normal controls or in tumour-bearing rats.

show abstract

“…The following case is one in which the Geiger probe technique has been used in association with radiotherapy (Hale, 1961;Bullen, Freundlich, Hale, Marshall, and Tudway, 1963).…”

mentioning

confidence: 99%

Recurrent gastric carcinoma treated by the Geiger probe technique.

Martin¹

1966

Gut

View full text Add to dashboard Cite

The Activity of Malignant Tumours and Response to Therapeutic Agents, Studied by Continuous Records of Radioactive Phosphorus Uptake

Cited by 30 publications

References 1 publication

Radioisotopes in the Investigation of Tumours [Abridged]

Radioisotopes in the Investigation of Tumours [Abridged]

Circadian variations in 32P uptake of a DMBA-induced mammary tumour and Walker carcinosarcoma in rats

Recurrent gastric carcinoma treated by the Geiger probe technique.

Contact Info

Product

Resources

About