The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells

Abstract

The results thus demonstrate that a 67-kDa molecule produced by rejected rat skin xenografts selectively inhibits iNOS activity in graft infiltrating macrophages. We suggest that NO does not play a significant role in rejection of skin xenografts as it does in the case of allograft rejection.

Cytokine Secretion Depends on Galα(1,3)Gal Expression in a Pig-to-Human Whole Blood Model

“…Whether IFN-␥ promotes or protects against xenograft rejection is unclear. A study by Wang et al (51) found that IFN-␥ together with IL-12 was protective against AHXR, whereas other studies have demonstrated that high levels of IFN-␥ are associated with rejection (52)(53)(54)(55). The precise role of IFN-␥ in xenotransplantation remains to be elucidated.…”

Xenotransplantation Literature Update May–June, 2005

“…As nitric oxide (NO) production by graft-infiltrating macrophages has been suggested to play an important role during skin allograft rejection, Holan et al [23] studied NO production and the expression of inducible NO synthase (iNOS) during rat-to-mouse skin transplantation. They observed that in xenogeneic rat skin grafts undetectable or only very low levels of NO were produced, as opposed to mouse skin allografts.…”

Caracterização da resposta inflamatória no enxerto singênico e alogênico em modelo experimental de transplante de pele.

“…Os resultados obtidos em nosso trabalho mostram que existe maior produção de óxido nítrico no enxerto alogênico quando comparado ao enxerto singênico. Estes resultados estão de acordo com dados da literatura, pois diversos trabalhos já demonstraram a correlação entre a produção de óxido nítrico e a rejeição de aloenxertos (Holan et al, 2002;Holan et al, 2005;Vos et al, 2000;Worrall et al, 1997). Altas concentrações de óxido nítrico podem auxiliar no processo de rejeição dos enxertos por causar destruição tecidual, esse composto induziria dano tecidual através do aumento a fibrose e necrose de tecidos (Kolb e Kolb-Bachofen, 1998;.…”

“…Além disso, existem diversos trabalhos associando a produção aumentada de óxido nítrico durante a rejeição de enxertos alogênicos (Holan et al, 2002;Holan et al, 2005;Vos et al, 2000;Worrall et al, 1997).…”