The activity of enzymes of glutathione metabolism in blood cells of patients with a high risk of manifestation of endogenous psychoses and patients with the first psychotic episode

Прохорова, Т. А.; Tereshkina, Elena B.; Savushkina, Olga K.; Boksha, Irina S.; Vorobyeva, E. А.; Омельченко, М. А.; Помыткин, А Н; Каледа, В. Г.; Бурбаева, Г. Ш.

doi:10.17116/jnevro201911904147

Cited by 13 publications

(6 citation statements)

References 27 publications

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“…They concluded that the activity of glutathione-dependent enzymes is impaired in schizophrenia spectrum disorders and the decreased level of GR and GST contributes to a reduction in antioxidant defense. For this reason, the evaluation of GR and GST activities could be a novel potential biomarker for predicting treatment response in this population [73,74]. However, two studies did not find any association between GSTP1 polymorphisms and schizophrenia, probably because GSTP1 polymorphisms do not affect protein levels, but modulate GSTP1 affinity to its substrates.…”

Section: Usefulness Of Gstp1-1 Enzymatic Activity In Some Pathologmentioning

confidence: 99%

Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution

et al. 2019

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Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects studies that propose GSTP1-1 as a useful biomarker in different fields of application. The most relevant studies are focused on GSTP1-1 as a biosensor to detect blood toxicity in patients affected by kidney diseases. In fact, this detoxifying enzyme is over-expressed in erythrocytes when unusual amounts of toxins are present in the body. Here we review articles concerning the level of GST in chronic kidney disease patients, in maintenance hemodialysis patients and to assess dialysis adequacy. GST is also over-expressed in autoimmune disease like scleroderma, and in kidney transplant patients and it may be used to check the efficiency of transplanted kidneys. The involvement of GSTP in the oxidative stress and in other human pathologies like cancer, liver and neurodegenerative diseases, and psychiatric disorders is also reported. Promising applications of e-GST discussed in the present review are its use for monitoring human subjects living in polluted areas and mammals for veterinary purpose.

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Section: Usefulness Of Gstp1-1 Enzymatic Activity In Some Pathologmentioning

confidence: 99%

Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution

et al. 2019

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“…Образцы крови обрабатывались в течение 2 ч после забора крови. Из образцов крови выделяли тромбоциты и готовили экстракт, как описано ранее [15].…”

Section: выделение тромбоцитов и определение активности глутатионовыхunclassified

“…Во всех этих группах тромбоцитарные активности GR и GST были ниже контрольных значений и различались у разных групп. Также были обнаружены достоверные и специфичные для той или иной группы корреляционные связи уровней активности ферментов с клиническими данными [14][15][16].…”

Section: при выписке/At the Time Of Dischargeunclassified

“…Ранее тромбоцитарные GR и GST изучались при шизофрении с ранней манифестацией и у молодых пациентов с высоким риском психозов [14][15][16], но нет исследований, посвященных этим антиоксидантным ферментам при поздно манифестирующих психозах шизофренического спектра (биохимические обследования таких больных не проводились). Вместе с тем актуально выяснить уровень активности глутатион-метаболизирующих ферментов при позднем развитии психозов для того, чтобы оценить вклад нарушений антиоксидантной защиты при обострении заболевания у этих больных.…”

unclassified

“…В настоящей работе, в отличие от наших предыдущих исследований [14][15][16], уровень тромбоцитарных ферментов GR и GST изучался у женщин с поздно манифестирующими расстройствами шизофренического спектра в сравнении с контрольной группой психически здоровых женщин того же возраста.…”

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Platelet Enzymes of Glutathione Metabolism in Patients with Late-Onset Schizophrenic Spectrum Disorders

Savushkina¹,

Boksha

Tereshkina³

et al. 2020

Psychiatry

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Background: basing on the hypothesis that oxidative stress participates in schizophrenia pathogenesis, the authors suggested that the activities of glutathione reductase (GR) and glutathione-S-transferase (GST), the enzymes metabolizing the central antioxidant glutathione, are altered in patients with schizophrenia spectrum disorders.Objective: determination of activity of platelet glutathione reductase (GR) and glutathione-S-transferase (GST) in patients with late-onset schizophrenic spectrum disorders (LOS - spectrum psychoses) and evaluation of their possible connection to clinical indicators.Patients and methods: 28 female in-patients aged 45–86 years with LOS-spectrum psychoses were examined: schizophrenia (n = 16), schizoaffective disorder (n = 6), chronic delusional disorder (n = 6). A control group of women of the same age range without mental and neurological diseases was recruited. Platelet GR and GST activities in patients were determined before and after the course of pharmacotherapy, and in the control group - only once.Results: assessment of the patients’ symptoms’ severity using PANSS, HAMD, and MMSE was carried out before and after the course of pharmacotherapy (at the 28th day of the therapy course). The efficacy of therapy was determined by the change in the PANSS and HAMD total score. While the GR activity did not differ significantly in patients and in the control group, GST activity was found substantially and significantly reduced in patients (before and after the course of therapy) compared with the control group, although GST activity in patients did not significantly change during their treatment. In both cases (GR and GST), three patients were observed among the patients with enzymatic activity exceeding > 1.5 times the medians in the group. After the course of treatment, the activity of enzymes decreased to a level within the range of control values or values for other patients.Conclusion: the results of a pilot study indicate the promise of determining the activity of GR and GST in a group of patients with LOS-spectrum endogenous psychoses to distinguish among them subgroups with glutathione metabolism abnormalities that correlate with clinical and pathopsychological features.

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Links of platelet glutamate and glutathione metabolism with attenuated positive and negative symptoms in depressed patients at clinical high risk for psychosis

Boksha

Омельченко

Savushkina

et al. 2022

Eur Arch Psychiatry Clin Neurosci

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The activity of enzymes of glutathione metabolism in blood cells of patients with a high risk of manifestation of endogenous psychoses and patients with the first psychotic episode

Cited by 13 publications

References 27 publications

Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution

Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution

Platelet Enzymes of Glutathione Metabolism in Patients with Late-Onset Schizophrenic Spectrum Disorders

Links of platelet glutamate and glutathione metabolism with attenuated positive and negative symptoms in depressed patients at clinical high risk for psychosis

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