The activity and compatibility of the antibiotic tiamulin with other drugs in poultry medicine—A review

Islam, Kazi Saiful; Klein, U.; Burch, David

doi:10.3382/ps.2009-00257

Cited by 52 publications

(43 citation statements)

References 42 publications

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“…There were no residues on day 5, which shows that the withdrawal period was less than 5 days (Table ). Our findings are in agreement with the results previously reported (EMEA, ; Islam et al, ). Shorter withdrawal period of tiamulin compared to other drugs like enrofloxacin, doxycycline, and tilmicosin (Anadon et al, , ; Sakthivel, ) can be advantageous from a public health point of view.…”

Section: Resultssupporting

confidence: 94%

“…There were no residues on day 5, which shows that the withdrawal period was less than 5 days (Table 3). Our findings are in agreement with the results previously reported (EMEA, 1999;Islam et al, 2009).…”

Section: Re Sults and Discussionsupporting

confidence: 94%

“…The causative organism, M. gallisepticum, is highly sensitive to quinolones, tetracyclines, macrolides, and tiamulin (Arzey & Arzey, 1992;Yang et al 2016;Yang, Sun, Zhao, Wang, & Wang, 2015). Tiamulin, a pleuromutilin derivative, is an ideal anti-mycoplasmal drug, due to its distinct advantages such as relatively high cure rate, very low "minimum inhibitory concentration" (MIC), least resistance development, and shorter withdrawal period (Islam, Klein, & Burch, 2009;Xia et al, 2016), and its use is approved in India.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics and relative bioavailability of tiamulin in broiler chicken as influenced by different routes of administration

Prabhakaran¹,

Srinivasan²,

Nair³

et al. 2019

Vet Pharm & Therapeutics

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The bioavailability and pharmacokinetic disposition of tiamulin in broiler chicken were investigated after administration through the crop, drinking water, and feed at 40 mg/kg body weight. Residues of tiamulin in tissues of broiler chicken were also assessed. Plasma and tissue concentrations of tiamulin were analyzed by reverse‐phase high‐performance liquid chromatography (HPLC) method. Plasma concentration–time data were described by the non‐compartmental model for all three routes, and pharmacokinetic parameters were calculated. There were no significant differences (p > 0.05) in pharmacokinetic parameters and mean plasma concentrations of tiamulin between three routes tested (crop, water, and feed), indicating equal efficacy. Tiamulin residues in edible tissues (muscles, skin, and fat) were lower than the advocated maximum residue limit (MRL of 0.1 µg/g and that of liver was 1 µg/g) on the 3rd day. No traces were found on the 5th day after drug administration. This indicated that the withdrawal period (less than 5 days) is very short, which makes it safer. This study shows that tiamulin can be used with equal efficacy through all routes of administration in broiler chicken (crop, water, and feed).

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Section: Resultssupporting

confidence: 94%

Section: Re Sults and Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics and relative bioavailability of tiamulin in broiler chicken as influenced by different routes of administration

Prabhakaran¹,

Srinivasan²,

Nair³

et al. 2019

Vet Pharm & Therapeutics

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“…19,26,27,36,37,46 Also the full susceptibility to tiamulin was expected since pleuromutilins are not frequently administered to poultry due to their lethal interactions with ionophore anticoccidials. 31 Among b-lactam antimicrobials, penicillines are widely used in the poultry industry, whereas cephalosporins are not currently approved for use in poultry in Italy. It has been reported that most C. coli and C. jejuni strains are intrinsically resistant to these antimicrobials due to the expression of blactamases.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance ofCampylobacter jejuniandCampylobacter colifrom Poultry in Italy

Giacomelli

Salata

Martini

et al. 2014

Microbial Drug Resistance

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This study was aimed at assessing the antimicrobial resistance (AMR) of Campylobacter isolates from broilers and turkeys reared in industrial farms in Northern Italy, given the public health concern represented by resistant campylobacters in food-producing animals and the paucity of data about this topic in our country. Thirty-six Campylobacter jejuni and 24 Campylobacter coli isolated from broilers and 68 C. jejuni and 32 C. coli from turkeys were tested by disk diffusion for their susceptibility to apramycin, gentamicin, streptomycin, cephalothin, cefotaxime, ceftiofur, cefuroxime, ampicillin, amoxicillin+clavulanic acid, nalidixic acid, flumequine, enrofloxacin, ciprofloxacin, erythromycin, tilmicosin, tylosin, tiamulin, clindamycin, tetracycline, sulfamethoxazole+trimethoprim, chloramphenicol. Depending on the drug, breakpoints provided by Comité de l'antibiogramme de la Société Française de Microbiologie, Clinical and Laboratory Standards Institute, and the manufacturer were followed. All broiler strains and 92% turkey strains were multidrug resistant. Very high resistance rates were detected for quinolones, tetracycline, and sulfamethoxazole+trimethoprim, ranging from 65% to 100% in broilers and from 74% to 96% in turkeys. Prevalence of resistance was observed also against ampicillin (97% in broilers, 88% in turkeys) and at least three cephalosporins (93-100% in broilers, 100% in turkeys). Conversely, no isolates showed resistance to chloramphenicol and tiamulin. Susceptibility prevailed for amoxicillin+clavulanic acid and aminoglycosides in both poultry species, and for macrolides and clindamycin among turkey strains and among C. jejuni from broilers, whereas most C. coli strains from broilers (87.5%) were resistant. Other differences between C. jejuni and C. coli were observed markedly in broiler isolates, with the overall predominance of resistance in C. coli compared to C. jejuni. This study provides updates and novel data on the AMR of broiler and turkey campylobacters in Italy, revealing the occurrence of high resistance to several antimicrobials, especially key drugs for the treatment of human campylobacteriosis, representing a potential risk for public health.

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“…The applicant performed a literature review to update the information available and two papers were identified as relevant . A review paper (Islam et al., ) confirmed the strong interaction at high dose (even leading to death) between the ionophore anticoccidials monensin, narasin and SAL when tiamulin is used at therapeutic levels. The interaction was found to be dose related, not observed at low dose.…”

Section: Assessmentmentioning

confidence: 97%

Safety and efficacy of Sacox® microGranulate (salinomycin sodium) for chickens for fattening and chickens reared for laying

Additives¹,

Rychen²,

Aquilina³

et al. 2017

EFS2

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Salinomycin sodium (SAL-Na) is active against certain Gram-positive bacteria, while Gram-negative species are resistant. SAL-Na at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli and Campylobacter and or induce resistance and cross-resistance to antimicrobials important in human and animal therapy. SAL-Na is safe for chickens for fattening at 70 mg/kg complete feed, for chickens reared for laying at 50 mg/kg complete feed in the first 12 weeks of life. The simultaneous use of SAL-Na and certain antibiotic drugs (e.g. tiamulin) is contraindicated. SAL-Na is absorbed and extensively metabolised. Metabolites have reduced ionophoric activity. SAL is the marker residue (MR). No residues in eggs are expected. SAL-Na is not genotoxic and not a carcinogen. A NOAEL of 0.5 mg/kg body weight (bw) per day is derived from a cardiovascular study in dogs as well as from a 12-month dog study. Consumer exposure complies with an acceptable daily intake of 0.005 mg SAL/kg bw after 1 h withdrawal. A withdrawal time and maximum residue limits are not considered necessary. SAL-Na from Sacox ® is not an irritant to skin and eyes; it is a potential sensitiser to skin and the respiratory tract. A toxicological risk by inhalation for persons handling the additive cannot be excluded. SAL-Na in feed for chickens will not pose a risk for the aquatic environment. A risk for the terrestrial ecosystem is considered unlikely due to metabolisation and the rapid degradation of SAL in the environment. SAL-Na at a minimum concentration of 50 mg/kg complete feed is an effective coccidiostat for chickens for fattening. This conclusion is extended to chickens reared for laying. SAL-Na in Sacox ® 120 microGranulate and Sacox ® 200 microGranulate is considered bioequivalent with respect to its anticoccidial effect.

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The activity and compatibility of the antibiotic tiamulin with other drugs in poultry medicine—A review

Cited by 52 publications

References 42 publications

Pharmacokinetics and relative bioavailability of tiamulin in broiler chicken as influenced by different routes of administration

Pharmacokinetics and relative bioavailability of tiamulin in broiler chicken as influenced by different routes of administration

Antimicrobial Resistance ofCampylobacter jejuniandCampylobacter colifrom Poultry in Italy

Safety and efficacy of Sacox® microGranulate (salinomycin sodium) for chickens for fattening and chickens reared for laying

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