The ACTIVE Trial: Comparison of the Effects on Renal Function of Iomeprol-400 and Iodixanol-320 in Patients With Chronic Kidney Disease Undergoing Abdominal Computed Tomography

Abstract

The incidence of CIN was significantly higher after IV administration of iodixanol-320 than iomeprol-400. The mean rise in SCr from baseline was also higher in patients receiving iodixanol.

The Role of Serum Cystatin C in the Early Detection of Contrast-Induced Nephropathy after Coronary Intervention

“…The results of the present study are in agreement with the most results obtained by others reports Kato et al and Mehran et al [19][20][21][22][23][24][25][26][27]. In present study was found a highly significant increment in serum creatinine and cystatin C while decrease in eGFR 24 hours after angiography (p<0.001, 0.01) when compared between two groups (CIN+, CIN-).…”

“…In present study was found a highly significant increment in serum creatinine and cystatin C while decrease in eGFR 24 hours after angiography (p<0.001, 0.01) when compared between two groups (CIN+, CIN-). This result is consistent with Wang et al, Liu et al and Nozue et al founded serum level of cystatin C is a reliable marker for CIN at 24 hours p<0.001 and serum creatinine increased significantly at 48 hours, also study carried by Wacker-Gussmann et al [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] found that cystatin C level and the cystatin C/creatinine ratio independently predict the risk of CIN in patients undergoing coronary angiography, but another study by Ribichini et al [32] found a significant increase in serum cystatin C concentrations 12 hours earlier than serum creatinine, therefore a rise of serum cystatin C at 12 hours from baseline was the earliest predictor of CIN than serum creatinine [18].…”

“…A prospective study of consecutive 87 patients who underwent elective PCI and CAG, 31 patients had a moderate kidney disease, CIN occurred in 18 patients and was more frequent 42.0% [19]. The reason for the difference in incidence rates of CIN among different studies including this study may be due to differences in the definitions of CIN (absolute or relative) [20,21]. Another reason is the number of patient's disparity as some researchers have their specimen number which is very large and others have a small as well as some of the researchers depend on the occurrence of the disease at 48 hours after angiography other research were taken 24 hours.…”

“…Although several studies have revealed that serum cystatin C cut off level >1.2 or >1.18 or >1.3 mg/l, 94% sensitivity and 48% specificity is more accurate for diagnostic CIN than serum creatinine [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. While study obtained by Ribichini et al found that absolute changes in serum creatinine proved more accurate than serum cystatin C for predicting CIN at an early stage 12 hours after angiography [18].…”

Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version

“…In a review of 7 prospective observational studies, the overall incidence of CIN was 5.4 % in patients with CKD who intravenously received low-or iso-osmolar contrast media, which suggested that intravenous administration of contrast media may pose a smaller risk of CIN as compared with that seen with intraarterial administration [42]. Table 7 lists the incidence of CIN in patients with CKD after receiving different contrast media [5,[65][66][67][68][69][70]. Table 8 Recently, CAG and catheter-based revascularization have become common procedures, and the use of contrast media has increased substantially.…”