The active components and the pharmacological multi-target principle of STW 5 (Iberogast®)

Wegener, Thomas; Wagner, Hildebert

doi:10.1016/j.phymed.2006.07.001

Cited by 48 publications

(51 citation statements)

References 126 publications

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“…16,[20][21][22][23][24] The current study has demonstrated that Iberogast ® improved histological parameters including a reduced jejunal ODS score and improved villus and crypt structure in the jejunum during 5-FU induced mucositis; however, Iberogast ® did not improve sucrase activity as indicated by the SBT and the sucrase assay.…”

Section: Discussionmentioning

confidence: 52%

“…Flavonoids, phenol carboxylic acids, coumarins and monoterpenes are the predominant anti-oxidative and anti-inflammatory substances in Iberogast ® . 24 Flavonoids and phenol carboxylic acids specifically target reactive oxygen species, such as singlet oxygen, peroxynitrite and hydrogen peroxide. 24 MPO is an enzyme found in activated neutrophils and utilises hydrogen peroxide to catalyse the…”

Section: Resultsmentioning

confidence: 99%

“…[16][17][18][19] Iberogast ® is a herbal formula comprised of nine different extracts including Iberus amara (bitter candy tuft) (15%), Angelica archangelica (angelica root) (10%), Matricaria recutita (chamomile) (20%), Carum carvi (caraway) (10%), Silybum marianum (St. Mary's thistle) (10%), Melissa officinalis (lemon balm leaf ) (10%), Mentha piperita (peppermint leaf ) (5%), Chelidonium majus (celadine herb) (10%) and Glycyrrhiza glabra (liquorice root) (10%). 16 Iberogast ® has been clinically prescribed to treat gastrointestinal disorders such as functional dyspepsia (FD) for more than 40 years 16,[20][21][22][23][24] and has indicated promise in alleviating the symptoms of irritable bowel syndrome (IBS), markedly modulating gastrointestinal motor and sensory function. 21 Therefore, the aim of the current study was to investigate whether Iberogast ® could reduce small intestinal damage in a 5-FU model of mucositis in Dark Agouti rats.…”

Section: Introductionmentioning

confidence: 99%

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The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis

Wright¹,

Yazbeck²,

Lymn³

et al. 2009

Cancer Biology & Therapy

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There is an acute need for the development of effective therapies for mucositis, a debilitating side effect of cancer chemotherapy. Iberogast ® is a herbal extract reported to possess anti-inflammatory properties. We investigated Iberogast ® for its potential to reduce the severity of 5-Fluorouracil (FU)-induced mucositis in rats. Rats were allocated to three treatment groups (n = 8) and gavaged daily with a 10% solution of Iberogast ® or water from day 0 to day 8. Rats were injected intraperitoneally with 5-FU (150 mg/kg) or saline on day 6, and killed after 72 h. In vivo and in vitro sucrase activity was assessed by 13 C-sucrose breath test (SBT) and sucrase assay respectively. Intestinal disease severity was determined by histological assessment of villus height and crypt depth. Significant increases in villus height (277 ± 9 μm) and crypt depth (67 ± 3 μm) were observed in 5-FU + Iberogast ® -treated rats compared with 5-FU + Water (224 ± 13 μm and 48 ± 2 μm respectively; p < 0.05). Sucrase activity was significantly reduced in all 5-FU groups compared to control. Significant reductions in SBT and sucrase activity were observed in all 5-FU groups compared with Saline + Water controls (p < 0.05). We conclude that although Iberogast ® partially improved the histopathological features of 5-FU induced mucositis, it conferred no significant protection as indicated by the assessed endpoints.

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Section: Discussionmentioning

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis

Wright¹,

Yazbeck²,

Lymn³

et al. 2009

Cancer Biology & Therapy

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show abstract

“…Since flavonoids, essential oils, hydroxycinnamic acid derivatives, coumarins, dicarboxylic acids, silymarins, amino acid derivatives and glycyrrhizic acid are the characteristic compounds of the individual ethanol extract of STW 5 (Kroll & Cordes, 2006;Wegener & Wagner, 2006); in this study, we decided to consider the preventive effect of ethanol extract of STW 5 in liver and lung tissues in CLP rat model by measuring the tissue histophatological parameters. Table 2.…”

Section: Discussionmentioning

confidence: 99%

“…The pharmacological effects, as well as the therapeutic effectiveness, tolerability and toxicity of Iberogast®, were experimentally and clinically recorded and documented using modern investigation tools. Both the experimental as well as the clinical studies indicated a regulatory influence of Iberogast® on the entire gastrointestinal tract (Wegener & Wagner, 2006;Khayyal et al, 2006;Mullera et al, 2006;Brierley & Kelber, 2011).…”

Section: Research Articlementioning

confidence: 96%