The activator domain of bacterial collagenases drives collagen recognition, unwinding and processing
Jamil Serwanja,
Alexander C. Wieland,
Astrid Haubenhofer
et al.
Abstract:Collagens form the resilient backbone of the extracellular matrix in mammals. Only few proteases are able to digest triple-helical collagen. Clostridial collagenases can efficiently process collagen. However, little is known about the mechanism of bacterial collagenolyis of either soluble collagen or the multi-hierarchically assembled, insoluble collagen fibers. Here we present a functional analysis of the distinct roles of the individual domains of collagenase G (ColG) from Hathewaya histolytica. A broad arra… Show more
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