The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases

Zajkowicz, Artur; Rusin, Marek

doi:10.1016/j.mad.2011.09.002

Cited by 19 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our observation on the lack of AICAR effects on p70/S6K phosphorylation are in line with previous findings (17). Our in vivo results are based on applying AICAR treatment concurrently with LTA administration.…”

Section: Discussionsupporting

confidence: 93%

AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation

Hoogendijk

Pinhanços

Poll

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: AMPK is a highly conserved energy homeostasis-regulating kinase. Results: Activation of AMPK by AICAR in vitro reduced cytokine production in alveolar macrophage cell line and in vivo reduced LTA-induced neutrophil influx, protein leak and cytokine/chemokine levels. Conclusion: AMPK activation inhibits LTA-induced lung inflammation in mice. Significance: AICAR reduces LTA inflammation.

show abstract

Section: Discussionsupporting

confidence: 93%

AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation

Hoogendijk

Pinhanços

Poll

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…Interestingly, in Hela cells lacking LKB1, AICAR-induced AMPK activation is blunted by KU-55933. A similar observation is reported by chronic incubation of cells with AICAR [29]. A third study has reported that ionizing radiation induces AMPK activation in A549 and H23 cells, both of which lack LKB1, an event that is inhibited by KU-55933 [27].…”

Section: Discussionsupporting

confidence: 70%

“…Recently, ATM has been implicated in metabolic pathways seemingly unrelated to DNA damage [23]. In addition, several reports have suggested this link may involve AMPK and IGF-1 signaling [24; 25; 26; 27; 28; 29; 30; 31; 32]. …”

Section: Introductionmentioning

confidence: 99%

ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis

Luo¹,

Huang²,

Tao³

et al. 2013

Cancer Letters

View full text Add to dashboard Cite

The present study aims to determine the effect of AMPK on etoposide-induced apoptosis of cancer cells. Our results revealed that etoposide induced AMPK activation in prostate C4-2 cancer cells, an event that was attenuated by ATM siRNA. In A549 cells that lack LKB1, AMPK was unable to be activated by etoposide, which was restored by introduction of LKB1. Likewise, silencing LKB1 in C4-2 cells impaired AMPK activation. Finally, etoposide displayed a potent pro-apoptotic effect in cancer cells with functional LKB1 and AMPK. Thus, our results establish a linear relationship of ATM, LKB1 and AMPK in response to the DNA damage drug.

show abstract

“…85 Interestingly, AICAR alone has been reported to signal through ATM in order to regulate AMPK activity. 86 Overall, an underlying mechanism of chemotherapy-induced DNA damage appears to also involve the activation of AMPK by ATM, in order to regulate pathways that mediate cell cycle checkpoints and survival (as seen in Fig. 4).…”

Section: Atm-ampk Activation By Chemotherapeutic Agentsmentioning

confidence: 99%

AMP-activated protein kinase (AMPK) beyond metabolism

Sanli

Steinberg

Singh

et al. 2013

Cancer Biology & Therapy

175

View full text Add to dashboard Cite

The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases

Cited by 19 publications

References 30 publications

AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation

AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation

ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis

AMP-activated protein kinase (AMPK) beyond metabolism

Contact Info

Product

Resources

About