The Activation Effects of Low Level Isopropyl Alcohol Exposure on Arterial Blood Pressures Are Associated with Decreased 5-Hydroxyindole Acetic Acid in Urine

Zhao, Zhiqiang; Liu, Xinxia; Xing, Xiumei; Lu, Yao; Sun, Yi; Su, Xiaolin; Jiang, Jun; Yang, Yarui; Chen, Jingli; Shen, Biling; He, Yun

doi:10.1371/journal.pone.0162762

Cited by 10 publications

(3 citation statements)

References 49 publications

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“…11 Isopropanol is being widely used in various applications such as lubricants, solvents, cosmetics, electronic industries for cleaning of printed circuit boards, pharmaceutical industries, household chemicals, and also in automotive eld as a petroleum additive. [12][13][14] However, exposure to isopropanol is very harmful to human health. Dizziness, severe vomiting, irritation of eyes, nose, throat, and mouth are the common symptoms that are being observed while exposing to low concentrated isopropanol (below 400 ppm).…”

Section: Introductionmentioning

confidence: 99%

NiO decorated CeO₂ nanostructures as room temperature isopropanol gas sensors

et al. 2019

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Section: Introductionmentioning

confidence: 99%

NiO decorated CeO₂ nanostructures as room temperature isopropanol gas sensors

et al. 2019

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“…The exposure of alcohol can be life threatening if no measures are taken properly. Alcohol such as isopropyl alcohol (isopropanol) is a clear, colorless, and flammable organic solvents [7]. There has been a report that isopropyl alcohol (IPA) exposure mainly affects the nervous system, but it may also lead to reproductive development problems [8].…”

Section: Photonic Sensorsmentioning

confidence: 99%

Demonstration of a Polymer-Based Single Step Waveguide by 3D Printing Digital Light Processing Technology for Isopropanol Alcohol-Concentration Sensor

2021

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A polymer based horizontal single step waveguide for the sensing of alcohol is developed and analyzed. The waveguide is fabricated by 3-dimensional (3D) printing digital light processing (DLP) technology using monocure 3D rapid ultraviolet (UV) clear resin with a refractive index of n = 1.50. The fabricated waveguide is a one-piece tower shaped ridge structure. It is designed to achieve the maximum light confinement at the core by reducing the effective refractive index around the cladding region. With the surface roughness generated from the 3D printing DLP technology, various waveguides with different gap sizes are printed. Comparison is done for the different gap waveguides to achieve the minimum feature gap size utilizing the light re-coupling principle and polymer swelling effect. This effect occurs due to the polymer-alcohol interaction that results in the diffusion of alcohol molecules inside the core of the waveguide, thus changing the waveguide from the leaky type (without alcohol) to the guided type (with alcohol). Using this principle, the analysis of alcohol concentration performing as a larger increase in the transmitted light intensity can be measured. In this work, the sensitivity of the system is also compared and analyzed for different waveguide gap sizes with different concentrations of isopropanol alcohol (IPA). A waveguide gap size of 300 µm gives the highest increase in the transmitted optical power of 65% when tested with 10 µL (500 ppm) concentration of IPA. Compared with all other gaps, it also displays faster response time (t = 5 seconds) for the optical power to change right after depositing IPA in the chamber. The measured limit of detection (LOD) achieved for 300 µm is 0.366 µL. In addition, the fabricated waveguide gap of 300 µm successfully demonstrates the sensing limit of IPA concentration below 400 ppm which is considered as an exposure limit by “National Institute for Occupational Safety and Health”. All the mechanical mount and the alignments are done by 3D printing fused deposition method (FDM).

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“…But low-level isopropanol exposure-caused potential health hazards are often ignored. Our research team found that even low-level isopropanol exposure could cause 5-hydroxy indole acetic acid (5-HIAA) decreasing, correlated with increased blood pressure [ 9 ]. Although the exact mechanism of action of isopropanol has not been fully elucidated, recent studies have suggested that isopropanol affects liver metabolic enzyme activity [ 10 ] and promotes the genotoxicity of other substances [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Telomere length in peripheral leukocytes is a sensitive marker for assessing genetic damage among workers exposed to isopropanol, lead and noise: the case of an electronics manufacturer

Liu

Zhao

et al. 2021

Genes and Environ

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Background Workers in electronics manufacturers may be exposed to various occupational hazards such as isopropanol, lead, and noise. Telomeres are special segments of cap-like DNA protein complex at end of liner chromosomes in eukaryotic cells. Telomere length is a potential marker of genetic damage. The aim of this study is to evaluate the effect of occupational hazards on the relative telomere length (rTL) of peripheral blood cells of workers in an electronics manufacturer, and to explore whether relative telomere length could be a biomarker for assessing genetic damage in the electronics manufacturing industry. Methods We investigated a large-scale electronics manufacturer in the Pearl River Delta Region. We ultimately collected 699 qualified workers (248 with isopropanol exposure, 182 with lead exposure, 157 with noise exposure, and 112 controls). During physical examination of the workers, we gave them questionnaires to understand their health statuses and living habits. We also collected peripheral blood samples from these workers to test exposure levels and rTL in the leucocytes. Results The concentrations of air isopropanol in all monitored workshops was 25.3 mg/m3 and air lead smoke was 0.020 mg/m3. The maximum equivalent continuous A sound level noise exposure position was 82.2dB (A). All were lower than those in the Occupational Exposure Limits in Workplaces in China. Urinary acetone in the isopropanol exposed group was 1.04 (0, 1.50) mg/L, and cumulative urinary acetone was 1.48 (0, 5.09) mg-years/L. Blood lead levels (BLLs) were 28.57 (22.77, 37.06) µg/dL, and cumulative blood lead levels (CBLLs) were 92.75 (55.47, 165.13) µg-years/dL. rTL was different between occupational exposed workers and controls: rTL was 0.140 units (95 % CI: 0.022, 0.259) shorter in lead exposed workers and 0.467 units (95 % CI: 0.276–0.658) shorter in noise exposed workers compared to the controls. There is no statistical difference in rTL between isopropanol exposure workers and the controls. In order to elucidate the relationship between rTL and occupational hazards exposure, we divided the isopropanol exposure workers into three groups (0, ~1.43 mg/L, and >1.43 mg/L). None of the rTL difference was statistically significant among exposed workers at different uroacetone levels (P>0.05). The groups with ≥100 µg/dL blood lead had shorter rTL than the group with blood lead below 100 µg/dL (F=4.422, P=0.013). We incorporated age, gender, birthplace, race, education level, smoking, and alcohol consumption into the linear regression equation. Only blood lead concentration (X) was entered into the regression equation, yielding a multivariate linear regression equation of Y=0.397-0.124X (F=8.091, P=0.005). Workers with different hearing loss also had statistically significant differences in rTL (F=5.731, P=0.004). rTL was a protective factor for the occurrence of noise-induced hearing loss (NIHL). The longer the rTL, the lower the risk of NIHL [OR=0.64 (0.42, 0.98)]. Conclusions rTL was shorter in lead exposed workers and noise exposed workers, and it was a protective factor for the occurrence of the noise-induced hearing loss. Thus, rTL of peripheral blood may be a sensitive marker of genetic damage among workers in environments with lead and noise exposure.

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The Activation Effects of Low Level Isopropyl Alcohol Exposure on Arterial Blood Pressures Are Associated with Decreased 5-Hydroxyindole Acetic Acid in Urine

Cited by 10 publications

References 49 publications

NiO decorated CeO₂ nanostructures as room temperature isopropanol gas sensors

NiO decorated CeO₂ nanostructures as room temperature isopropanol gas sensors

Demonstration of a Polymer-Based Single Step Waveguide by 3D Printing Digital Light Processing Technology for Isopropanol Alcohol-Concentration Sensor

Telomere length in peripheral leukocytes is a sensitive marker for assessing genetic damage among workers exposed to isopropanol, lead and noise: the case of an electronics manufacturer

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The Activation Effects of Low Level Isopropyl Alcohol Exposure on Arterial Blood Pressures Are Associated with Decreased 5-Hydroxyindole Acetic Acid in Urine

Cited by 10 publications

References 49 publications

NiO decorated CeO2 nanostructures as room temperature isopropanol gas sensors

NiO decorated CeO2 nanostructures as room temperature isopropanol gas sensors

Demonstration of a Polymer-Based Single Step Waveguide by 3D Printing Digital Light Processing Technology for Isopropanol Alcohol-Concentration Sensor

Telomere length in peripheral leukocytes is a sensitive marker for assessing genetic damage among workers exposed to isopropanol, lead and noise: the case of an electronics manufacturer

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NiO decorated CeO₂ nanostructures as room temperature isopropanol gas sensors

NiO decorated CeO₂ nanostructures as room temperature isopropanol gas sensors