The activation and osteoinduction effects of thrombin in the maxillary sinus augmentation process: does thrombin only display activation effects on platelet-rich plasma?

Chen, T.-L.; Lu, Hong-jun; Zhang, X.-H.; Wang, S.-F.; Bao, Hongwei; Tang, Dahai

doi:10.1016/j.ijom.2015.01.004

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…In clinical and experimental studies, Grageda et al proved the role of PRP in the repair of periodontal and maxillofacial bone defects [5,6]. However, Khairy demonstrated that PRP enrichment did not significantly improve bone density or morphometric value at 3 months post graft [7,8]. Faratzis showed that autogenous PRP had not significant effects on HA/ β-TCP promoting rabbits bone defects repair at 6 weeks post graft [9,10].…”

Section: Introductionmentioning

confidence: 99%

Biological Effects and Molecular Mechanisms of Platelet-Rich Plasma on Periodontal Bone Regeneration

Chen

Yue

Wang

et al. 2022

WJDSR

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Objective:The study investigated the biological effects and molecular mechanisms of platelet-rich plasma (PRP) on periodontal bone regeneration. Methods: Electronic and manual searches were searched up to 1 October 2022 in the following databases: Pubmed, Scopus, Cochrane Library and Embase. [Platelet rich plasma or platelet or growth factors] and [periodontal] or [bone regeneration or bone defect or bone reconstruction] were used for searching. This study reviewed and analyzed published papers associated with PRP and periodontal bone defect restoration or bone regeneration or bone reconstruction. Results: Different growth factors exhibited varied biological characteristics and function. In-vitro studies, animal experiments and clinical studies confirmed that PRP displayed assorted role in periodontal bone defects repair. The growth factors secreted from PRP can promote new bone formation, soft tissue regeneration and wound healing. The fiber threedimensional structure in PRP is conducive to the growth and migration of cells and provides strong support for the regeneration of periodontal soft and hard tissues. The anti-inflammatory characteristics of PRP are also closely related to the repair of periodontal bone defects. Conclusion: PRP played an important biological effect on periodontal bone regeneration. The mechanism is closely related to PRP promoting the growth, proliferation, differentiation and migration of periodontal ligament cells and osteoblasts, and the fiber stereo configuration of PRP and the antiinflammatory effect of leukocytes.

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