The Activated Notch1 Signal Pathway Is Associated with Gastric Cancer Progression through Cyclooxygenase-2

Yeh, Tien Shun; Wu, Chew N.; Hsu, Kai-Wen; Liao, Wan Jung; Yang, Min; Li, Anna Fen Yau; Wang, An Ming; Kuo, Min-Liang; Wen, Chin

doi:10.1158/0008-5472.can-08-4021

Cited by 145 publications

(157 citation statements)

References 51 publications

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“…Illustrating the diverging impact of Notch according to histological subgroups, we report, for the first time, Notch-1 as an independent negative prognostic factor in NSCLC patients with AC. Our findings corroborate previous results in other malignancies, such as breast 15 and gastric cancer, 16 but are in contrast to results from a colorectal study, 17 where no association was found, and a bladder cancer study 18 reporting high Notch-1 expression to indicate a good prognosis. In an IHC study of 153 NSCLC patients, Lee et al reported Notch-1 to be negatively correlated to lymph node metastasis, but did not show any prognostic value.…”

Section: Discussionsupporting

confidence: 89%

Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer

Dønnem

Andersen

Al-Shibli

et al. 2010

Cancer

115

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BACKGROUND:Notch signaling plays a key role in embryonic vascular development and angiogenesis. The authors aimed to study the prognostic role of the angiogenesis‐related Notch ligands and receptors and investigate the prognostic impact of the coexpression of vascular endothelial growth factor‐A (VEGF‐A) and Notch signaling.METHODS:Tumor tissue samples from 335 resected patients with stage I to IIIA nonsmall cell lung cancer (NSCLC) were obtained, and tissue microarrays were constructed from duplicate cores of tumor cells and tumor‐related stroma from each specimen. Immunohistochemistry was used to evaluate the expression of the molecular markers Notch‐1, Notch‐4, Delta‐like ligand 4 (DLL4), and Jagged‐1.RESULTS:There were 191 squamous cell carcinomas (SCCs), 113 adenocarcinomas (ACs), and 31 large cell carcinomas. In AC, low tumor cell Delta‐like ligand 4 expression was an independent negative prognostic factor (hazard ratio [HR], 2.9; 95% confidence interval [CI], 1.4‐6.3 [P = .006]), whereas high tumor cell Notch‐1 expression was an independent negative prognostic factor (HR, 2.2; 95% CI, 1.2‐4.1 [P<.001]). In SCC, low stromal Delta‐like ligand 4 expression was an independent indicator of poor prognosis (HR, 3.3; 95% CI, 1.8‐6.1 [P<.001]). The coexpression of Notch‐1 and VEGF‐A had a significant prognostic impact (P<.001). For Notch‐1 and VEGF‐A, low/low (n = 142) versus high/high (n = 35) expression resulted in 5‐year survival rates of 69% and 32%, respectively.CONCLUSIONS:Delta‐like ligand 4 and Notch‐1 are independent prognostic factors in NSCLC, but have diverse impacts in SCC and AC. The coexpression of tumor cell Notch‐1/VEGF‐A has a major impact on survival. Cancer 2010. © 2010 American Cancer Society.

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Section: Discussionsupporting

confidence: 89%

Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer

Dønnem

Andersen

Al-Shibli

et al. 2010

Cancer

115

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“…16 In addition, activation of notch1 signal pathway was confirmed to promote invasion and colony formation ability of gastric cancer through COX-2. 17 Conversely, transfection of constitutive notch1 plasmid led to growth inhibition in thyroid cancer cells, DRO and FTC236. 18 In GBM, notch1 and its ligands are reported to be overexpressed, and knockdown of notch1 induces apoptosis and inhibits proliferation.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme

Li¹,

Ma²,

Dong³

et al. 2011

Cancer Biology & Therapy

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“…The Notch 1 signaling pathway, in particular, draws great attention in the research of the Notch signaling pathway in GC. At present, Notch 1 seems to function as an oncoprotein in GC, as evidenced by a recent report that Notch 1 contributed to GC progression by inducing COX2 expression (71). Furthermore, Yao et al (72) reported that activation of the Notch 1 receptor can reduce TNFα-induced apoptosis in BGC-823 cells.…”

Section: Breast Cancermentioning

confidence: 97%

Notch and Wnt signaling pathway in cancer: Crucial role and potential therapeutic targets (Review)

Xiao

Xin

Tang

et al. 2015

International Journal of Oncology

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Abstract. There is no radical cure for all cancer types. The most frequently used therapies are surgical treatment, radiotherapy and chemotherapy. However, recrudescence, radiation resistance and chemotherapy resistance are the most challenging issues in clinical practice. To address these issues, they should be further studied at the molecular level, and the signaling pathways involved represent a promising avenue for this research. In the present review, we mainly discuss the components and mechanisms of activation of the Notch and Wnt signaling pathways, and we summarize the recent research efforts on these two pathways in different cancers.

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The Activated Notch1 Signal Pathway Is Associated with Gastric Cancer Progression through Cyclooxygenase-2

Abstract: Gastric carcinoma is one of the most common cancers and lethal malignancies worldwide. Thus far, the regulatory mechanisms of its aggressiveness are still poorly understood.

Cited by 145 publications

References 51 publications

Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer

Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer

MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme

Notch and Wnt signaling pathway in cancer: Crucial role and potential therapeutic targets (Review)

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