The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55

Yamashita, Atsushi; Oka, Saori; Tanikawa, Takashi; Hayashi, Yasuhiko; Nemoto-Sasaki, Yoko; Sugiura, Takayuki

doi:10.1016/j.prostaglandins.2013.05.004

Cited by 64 publications

(59 citation statements)

References 108 publications

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“…LysoPI is a second messenger that regulates a wide range of physiological processes, such as inflammation, angiogenesis, and atherosclerosis 34, 42, 43 . When coordinated with its receptor, lysoPI leads to neutrophil polarization and the abrogation of reactive oxygen species (ROS) formation, thus limiting inflammation 44 . Additionally, our results suggest that the human and mouse macrophages showed different lipid profile features.…”

Section: Discussionmentioning

confidence: 99%

Quantitative profiling of glycerophospholipids during mouse and human macrophage differentiation using targeted mass spectrometry

Zhang

Wang

et al. 2017

Sci Rep

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Macrophage lipid metabolism plays a pivotal role in innate and adaptive immune responses. Previous studies have shown that this process plays a role in infections and contributes to the pathogenesis of diabetes, atherosclerosis, and other immunometabolic diseases. M1 macrophages, or classically activated macrophages, are key players in the defense against bacterial infections. M2 macrophages, or alternatively activated macrophages, are involved in anti-inflammatory responses. Using the multiple reaction monitoring method, we identified changes in lipid composition during the differentiation of human and murine macrophages. We detected over 300 lipid molecules in mammalian macrophages, and we observed a striking shift in the composition of glycerophospholipids (GLs) from saturated and monounsaturated to polyunsaturated during human macrophage polarization. Moreover, M2 macrophages showed a higher level of lysophospholipids (lysoGLs) than did M1 macrophages. The lysoPI species increased in human and mouse M2 macrophages, suggesting that they may be involved in M2 macrophage polarization and anti-inflammatory processes. Collectively, these results indicate that lipids may play a role in the pro- and anti-inflammatory activities of macrophages and may be markers of the macrophage activation state.

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Section: Discussionmentioning

confidence: 99%

Quantitative profiling of glycerophospholipids during mouse and human macrophage differentiation using targeted mass spectrometry

Zhang

Wang

et al. 2017

Sci Rep

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“…In addition, DDHD1 has been recently involved in the formation of lysophosphatidylinositol (LPI), and in particular of 2-arachidonoyl LPI [12], a lipid mediator with various physiological functions, including Ca 2? mobilization and cell migration and proliferation [13].…”

Section: Discussionmentioning

confidence: 99%

Impairment of brain and muscle energy metabolism detected by magnetic resonance spectroscopy in hereditary spastic paraparesis type 28 patients with DDHD1 mutations

et al. 2014

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neuropathy, distal sensory loss, and cerebellar eye movement disturbances. We screened 96 index subjects from recessive HSP families for mutation and identified one family with two sibs carrying mutations in DDHD1 gene.were performed, including MR spectroscopy of brain and muscle of the two mutated patients. Two novel heterozygous mutations in DDHD1 were found in the affected the SPG28 subtype. Of note, MR spectroscopy of brain and Abstract Mutations in DDHD1 gene have been associmuscle in these patients indicated a mild deficit of brain ated with the SPG28 subtype of Hereditary Spastic Paraenergy metabolism in the oldest and most severely affected paresis (HSP). Clinical phenotype includes axonal patient, while an impairment of energy metabolism was found in the skeletal muscle of both patients. Unlike the DDHD2 mutated patients, no evidence of lipid accumulation in the brain was found. Our data along with those previously reported suggest a dysfunction in the OXPHOS Clinical, neuropsychological, and neuroimaging studies system possibly due to mitochondrial lipid content modification, which could be a central mechanism in the pathogenesis of SPG28.members of one family, with clinical features overlapping

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“…Consequently, they suggested that these cancer cells synthesize and export LPI (via MRP1), which then acts in an autocrine fashion to promote their own proliferation. LPI has an extensive range of both nonreceptor-mediated and receptor-mediated activities (80,81). Most of its receptor-mediated effects occur via activation of the GPCR GPR55.…”

Section: Lipid-derived Signaling Molecules As Substrates Of Mrp1mentioning

confidence: 99%

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

Cole

2014

Journal of Biological Chemistry

273

245

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The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a broader role than simply mediating the ATP-dependent efflux of drugs from cells. The antioxidant GSH and the pro-inflammatory cysteinyl leukotriene C 4 have been identified as key physiological organic anions effluxed by MRP1, and an ever growing body of evidence indicates that additional lipid-derived mediators are also substrates of this transporter. As such, MRP1 is a multitasking transporter that likely influences the etiology and progression of a host of human diseases.

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The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55

Cited by 64 publications

References 108 publications

Quantitative profiling of glycerophospholipids during mouse and human macrophage differentiation using targeted mass spectrometry

Quantitative profiling of glycerophospholipids during mouse and human macrophage differentiation using targeted mass spectrometry

Impairment of brain and muscle energy metabolism detected by magnetic resonance spectroscopy in hereditary spastic paraparesis type 28 patients with DDHD1 mutations

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

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