The Action of Succinylcholine on the Tension of Extraocular Muscle

Comparison of the Effects of Etomidate and Thiopentone on Intraocular Pressure

“…Various factors can alter IOP during anaesthesia. Atropine was the only premedication given to the patients because it does not produce any change in IOP (Eakin and Katz, 1966). Oji and Holdcroft (1969) studied the effects of etomidate on IOP and suggested that the observed decrease in IOP could be the result of the accompanying decrease in the systolic arterial pressure.…”

Curare‐like Effect of Propranolol on Rat Extraocular Muscles

“…Neither of these pharmacological actions appears to be involved in the reduction of SChevoked tensions here described. The possibility that this reduction is due to a blockade of the adrenergic mechanism suggested by Eakins & Katz (1966) to modulate SCh responses in extraocular muscles can be ruled out because both isomers of the drug were Significant for paired data: *(P < 0.01), **(P < 0.005), ***(P < 0.001).…”

“…Studying the contractile responses evoked in cat EOM by intravascular injections of succinylcholine (SCh), Eakins & Katz (1966) found that pronethanol, a fi-adrenoceptor blocker, had a long lasting depressant action on SCh-evoked tensions. In addition they observed that adrenaline exerted a weak stimulating effect on EOM.…”

“…Multiply innervated fibres respond to depolarizations caused by cholinomimetic agents or by elevated K concentrations with sustained tensions in vivo and in vitro (Duke Elder & Duke Elder, 1931;Lincoff, Breinin & De Voe, 1957;Eakins & Katz, 1966;Chiarandini, 1976).…”

Suxamethonium-A Review: Part III—Pharmacological Actions of Suxamethonium Apart from Its Neuromuscular Blocking Effect

“…It was originally thought that contraction of the extraocular muscles was responsible for the raised pressure (Hofmann and Holzer 1953, Lincoff et al 1955, Dillon et al 1957a, 1957b, Schwartz and de Roetth 1958. These muscles are highly specialized and are unlike striated muscles found elsewhere in the body (Lincoff et al 1955, Carballo 1965, Eakins and Katz 1966, Katz, Eakins and Lord 1968. They contain two separate neuromuscular systems.…”