“…These antibiotics block several DNA-dependant polymerases of mammalian cells (Wehrli et al, 1968;Juhasz et al, 1972;Srb et al, 1974) and probably affecting in this way the interferon production Alonso, 1973, 1974), as well as the humoral and cellular immune responses (Sung, 1974;Paunescu, 1970;Dajani et al, 1973;Floersheim, 1973). However, the effect of these antibiotics could be due to an inhibitory action on the mitochondria (Gadaleta et al, 1970).…”