The action of methysergide in manic states

Haskovec, L; Souček, Karel

doi:10.1007/bf00403717

Cited by 4 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Open trials have been published claiming dramatic responses to methysergide within 24 to 48 hours of commencing treatment (Verster, 1963;Dewhurst, 1968;Haskovec and Soucek, 1969). McCabe et al (1970) had one favourable response out of eight subjects in an open trial, but they used the drug in comparatively low dosage (6-8 mg) and over a brief period (four to five days).…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that intrathecal or intramuscular administration of methysergide may be necessary for therapeutic effect (Haskovec, 1969). This view does not reconcile conflicting evidence about the use of the oral form.…”

Section: Discussionmentioning

confidence: 99%

“…On the basis that methysergide is an antagonist of tryptamine and 5-hydroxytryptamine, Dewhurst (1965) suggested that the drug may be effective in the treatment of mania. Independent reports from three separate centres have claimed dramatically favourable results in controlled studies on small numbers of patients (Verster, 1963;Dewhurst, 1968;Haskovec and Soucek, 1969).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Methysergide in mania: a double-blind comparison with thioridazine

1972

View full text Add to dashboard Cite

SYNOPSISDuring 20 separate illnesses 17 severely disturbed manic patients were given either methysergide or thioridazine in a 21 day double-blind controlled trial. For most of the trial patients received either 9 mg methysergide or 450 mg thioridazine daily; during one 24-hour period 12 mg methysergide or 600 mg thioridazine was administered. Daily clinical assessments were made. Methysergide proved significantly less effective than the phenothiazine.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Methysergide in mania: a double-blind comparison with thioridazine

1972

View full text Add to dashboard Cite

show abstract

Electroencephalographic study of the effects of methysergide on sleep in the rabbit

Tabushi¹,

Himwich²

1971

Electroencephalography and Clinical Neurophysiology

View full text Add to dashboard Cite

Drugs and Depression

Whitlock

Evans

1978

Drugs

View full text Add to dashboard Cite

Moderate or severe depression is now one of the most common diseases of our time with a prevalence of nearly 3%. It seems likely that this prevalence has increased as a result of the wider use of drugs which have an effect on the neurotransmitters. Changes in the levels of these neurotransmitters in the central nervous system are thought to be the biochemical basis for the development of at least some depressive illnesses. Drug-induced depressions are more likely to occur in those individuals who are genetically predisposed to depression or who have had a previous depressive illness. Other groups who are particularly susceptible to these effects are the elderly. Many groups of drugs have a primary or secondary action on the central nervous system neurotransmitter function. Some 200 drugs have been claimed to cause depression in certain patients, but only a relatively small number precipitate depressive symptoms with any frequency. Those most commonly implicated are the long-acting antipsychotics, barbiturates, ethanol, oral contraceptives and antihypertensive agents. It is important to remember that some drugs, such as reserpine, cause depression as a side-effect during their therapeutic use whereas others, such as fenfluramine, cause depression mainly when they are withdrawn too rapidly. In those patients presenting with depression, it is important to review the current drug therapy in order to assess the part played by these drugs in the development of the depression. Following this assessment, drug therapy should be adjusted appropriately. However, a distinction must be made between the symptoms of depression, those physiological changes which occur during treatment with a variety of drugs, and the patient's reaction to the disease for which they are being treated.

show abstract

The action of methysergide in manic states

Cited by 4 publications

References 19 publications

Methysergide in mania: a double-blind comparison with thioridazine

Methysergide in mania: a double-blind comparison with thioridazine

Electroencephalographic study of the effects of methysergide on sleep in the rabbit

Drugs and Depression

Contact Info

Product

Resources

About