The action of gamma aminobutyric acid upon cortical electrical activity in the cat

Iwama, Kitsuya; Jasper, Herbert H.

doi:10.1113/jphysiol.1957.sp005856

Cited by 116 publications

(33 citation statements)

References 26 publications

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“…Prolongation of sleeping time in pentobarbitoneinduced sleeping time test is may be because of enhancement in brain GABA as it is known to have depression action in brain as reported by Iwama et a1. 9 In locomotor activity testing, decrease in rearing along with locomotor activity is observed, that reveals depressive effect on CNS as reported by Leewanich et al l0 Overall we can say that PEE is having good CNS depressant activity.…”

supporting

confidence: 55%

Central Nervous System Depressant Activity of <i>Wedelia trilobata</i> Leaves

Tambe

Nirmal

Jadhav

1970

Dhaka Univ. J. Pharm. Sci

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supporting

confidence: 55%

Central Nervous System Depressant Activity of <i>Wedelia trilobata</i> Leaves

Tambe

Nirmal

Jadhav

1970

Dhaka Univ. J. Pharm. Sci

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“…Directly evoked cortical potentia18 Iwama & Jasper (1957) and Purpura et al (1959), who studied the effects of topically applied solutions of GABA on the response evoked in the cerebral cortex by stimulation of a nearby point, found that application of a 1 % GABA solution resulted in abolition of the surface negative response, leaving only a positive deflexion. Purpura et al have further reported that this property is possessed also by f-alanine, guanidinoacetic acid and BGPA, and that GGBA reduced the negative phase of the response and eliminated the appearance of the positive wave as well.…”

Section: Resultsmentioning

confidence: 99%

The effects of γ‐aminobutyrio acid and other compounds on structures of the mammalian nervous system which are inhibited by Factor I

Honour¹,

McLennan²

1960

The Journal of Physiology

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“…However, the mode of biogenesis remains still to be settled in detail. Although Grundfest (4) and Purpura et al (9,11,12) have regarded the DR as the summation of the two opposing excitatory and inhibitory postsynaptic potentials, their hypothesis has been bombarded relating to the effects of GABA on the DR (10,13,19). The biphasic effects of topically applied GHB on the DR, an aug mentation in the small dose and an inhibition in the large dose, may serve also for the clue to know the biogenesis of the potential.…”

Section: Discussionmentioning

confidence: 99%

The Central Action of Gamma-Butyrolactone and Gamma-Hydroxybutyrate

Bant

Hojo

1969

Japanese Journal of Pharmacology

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The biphasic mode of action of gamma-butyrolactone (GBL) and ,gamma-hydroxybuty rate (GHB) in the central nervous system has been confirmed in the previous report (1) . The former compound elevates the reticular arousal stimulation threshold for the mani festation of the hippocampal theta waves without significantly affecting the increased mani festation of the fast waves in the rabbit's EEG. At the same time , the thalamic recruit ing response is usually depressed or sometimes is slightly augmented . In order to observe the mode of action on the brain structures more in detail, the effects of both compounds on the cortical dendritic responses (DR) caused by the electrical stimulation of the corti cal surface are studied in the cats.The small doses of GHB augment the DR , while the large doses inhibit it. Based on the obtained results the dose-response relationship of GHB and its related compounds is discussed. On the other hand, GBL proved to be inactive in this respect . Correla tion of the effects between GHB and gamma-aminobutyric acid (GABA) , the latter of which is now accepted as the inhibitory transmitter in the several parts of the central nervous system, is also investigated. Roth et al. (2, 3) have already postulated that GHB is the pharmacologically active metabolite derived from gamma-butyrolactone in the body. METHODSFemale or male cats weighing 1.8 to 4 .2 kg were anesthetized with ether inhalation or with intraperitoneal injection of 40 to 50 mg/kg of o-chloralose or 30 mg/kg of pento barbital sodium. After the tracheal intubation the anesthetized cats with ether were made as encephale isole preparation and were maintained on the artificial respiration . All the anesthetized animals were fixed of their heads on the stereotaxic instrument of Todai-Noken type. The contact surface of the animal body with frame bars of the instrument was , when required, anesthetized with the topical application of xylocaine hydrochloride . Constant level of the nnecthee;a wnwac attn;nvr1 1-.v the S7unnlementnrv inieetinn of nentnl.a, h;tal nr

show abstract

The action of gamma aminobutyric acid upon cortical electrical activity in the cat

Cited by 116 publications

References 26 publications

Central Nervous System Depressant Activity of <i>Wedelia trilobata</i> Leaves

Central Nervous System Depressant Activity of <i>Wedelia trilobata</i> Leaves

The effects of γ‐aminobutyrio acid and other compounds on structures of the mammalian nervous system which are inhibited by Factor I

The Central Action of Gamma-Butyrolactone and Gamma-Hydroxybutyrate

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