The Action of Colchicine on Cell Division in Human Cancer, Animal, and Plant Tissues

Levine, Michael

doi:10.1111/j.1749-6632.1951.tb30070.x

Cited by 20 publications

(4 citation statements)

References 42 publications

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“…This anti-mitotic substance has previously been used to cause embryonic death in mice (Kerr, 1947), in which animals suitable intramuscular doses caused death of the embryo and membranes within 12 hr. Kerr has described in detail the degenerative processes which follow death of the mouse embryo from colchicine, while the mode of action of the drug has been described by Levine (1948).…”

Section: Introductionmentioning

confidence: 99%

Early Embryonic Death and Subsequent Cycle Length in the Ewe

Edey¹

1967

Reproduction

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Injections of colchicine into the lumen of the uterus of the ewe have been employed to cause timed embryonic deaths between Day 5 and Day 19 after ovulation. The length of oestrous cycles following embryonic death has then been studied. Control ewes had a mean cycle length of 17\m=.\44 \ m=+-\ 1 \ m =. \ 0 6 days, and the cycle length of ewes treated on Days 5, 7, 9 and 11 did not differ significantly from the controls. Ewes treated on Day 13 had a mean cycle length of 19\m=.\75\ m= +-\ 0\m=.\90 days, a highly significant increase over the controls. Embryonic death on Days 15 and 19 caused mean extensions of the cycle length of approximately 8 and 18 days respectively, but with wide individual variation. The results are discussed in relation to the maintenance and regression of the corpus luteum in the presence of embryonic substance. The findings indicate that in the field, embryonic death occurring on or before Day 11 is unlikely to be distinguished from fertilization failure.

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Section: Introductionmentioning

confidence: 99%

Early Embryonic Death and Subsequent Cycle Length in the Ewe

Edey¹

1967

Reproduction

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“…It was considered desirable to have as the test organisms large populations of more or less homogenous, actively multiplying bacteria. This would closely approach the conditions under which the action of colchicine has been observed in plants and animals (Levine, 1951). Experimentation was confined to the logarithmic phase of growth, since this is the period of most rapid multiplication and, hence, the period in which the mitotic cycle would be most in evidence.…”

Section: Discussionmentioning

confidence: 87%

“…The exact time at which recovery begins in S. typhosa is not known, since living cells were not studied as with B. megaterium. Levine (1951) observed that in the root tips of Allium cepa 3.6 peI cent of the cells were in metaphase. After 24 hr exposure to 0.01 per cent colchicine, 14.88 per cent metaphases were seen.…”

Section: 16mentioning

confidence: 99%

SOME OBSERVATIONS ON THE EFFECT OF COLCHICINE UPON SALMONELLA TYPHOSA

Minsavage

DeLamater

1955

J Bacteriol

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“…No attempt can be made in this paper to review the vast literature on mitotic poisons, or the literature which has accumulated on colchicine alone since the papers of Dustin and of Lits,in 19.34, focussed attention upon its effects on cell division. For the latter, the Eigsti bibliographies of colchicine (1947,1949), The Tissue Culture Bibliography (19.53), and a brief review by Levine (1951) may lead into the subject.…”

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confidence: 99%