The action of anticonvulsant drugs tested by electrical stimulation of the cortex, diencephalon and rhinencephalon in the unanesthetized rabbit

Gangloff, H.; Monnier, M

doi:10.1016/0013-4694(57)90110-4

Cited by 57 publications

(20 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The behavioral wakefulness and the alert pattern of EEG were also observed by Sigg (19) in the cats received 0.3 mg/kg of imipramine. The manifes tation of the resting pattern in the EEG by 1 to 5 mg/kg of chlorpromazine irrespective of the previous background activity was in the same line with the results shown by many workers (10,20). Some dissociation of the EEG effects between the cortex and the hippocampus was observed in a few animals treated with either agent .…”

Section: Discussionsupporting

confidence: 90%

“…The dissociation between the spontaneous EEG and behavior was observed until 18 hours after the administration of reserpine . The alert pattern of the spontaneous EEG by reserpine has also been reported in the acute preparations by Rinaldi et al (9) and Gangloff et al (10). Pscheidt et al (11) have indi cated that the spontaneous EEG in the restrained rabbits turns to the alert pattern at 3 to 6 hours after the fixation, and therefore , the alert pattern in the animals treated with 1 to 5 mg/kg of reserpine can not be differentiated from the same pattern in the non-treat ed ones at least from 3 hours after the fixation .…”

Section: Discussionsupporting

confidence: 65%

See 1 more Smart Citation

Comparative Studies on the Eeg Effects of Imipramine and Chlorpromazine in the Normal and Reserpinized Rabbits

Kamiya¹

1967

Jpn.J.Pharmacol

View full text Add to dashboard Cite

Among a series of clinically available psychopharmacological agents chlorproma zine is known to be effective against the reactive or neurotic depressive disorders with little effect on the endogenous depression, while imipramine is described to be very effec tive against the endogenous disorders by activating the psychic processes rather than by sedating. Therefore, the comparison of the pharmacological effects of both agents has been a matter of much concern. Domenjoz and Theobald (1) have found little difference in the anti-acetylcholine, anti-barium chloride and anti-serotonin potencies between imipramine and chlorpromazine using the isolated small intestine. However, relative anti-histamine potency appeared to depend upon the experimental preparations used.Chlorpromazine proved more potent against histamine on the isolated ileum, while imi pramine was more potent in antagonizing the effects of histamine on the ear vessels of rabbits. Sigg (2) has reported that both agents prolong the barbiturate sleep and alcohol sedation and depress the motor activity in mice and the conditioned avoidance response in rats, though chlorpromazine is more potent than imipramine in all respects. Further, he has shown the difference between both agents in the peripheral effects; imipramine potentiates the contractile responses of the nictitating membrane of cats to stimulation of the cervical sympathetic nerve and to exogenously administered noradrenaline or serotonin, but chlorpromazine suppresses either response. He has also described the divergency in the effects of both agents on the pressor responses of dogs to noradrenaline. Thoenen et al. (3,4) have shown the potentiating effect of imipramine on the contractile response and noradrenaline output of the isolated perfused spleen of cats to sympathetic stimulation, in contrast to the suppressing effect of chlorpromazine. Axelrod et al. (5,6) have demonstrated that imipramine inhibits the uptake of tri tiated noradrenaline in the brain of intact rats, while chlorpromazine does not. It is well known that the effects of imipramine and chlorpromazine on the spontaneous EEG coincide well; both agents produce the resting pattern intermingled with the spindle bursts.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 65%

Comparative Studies on the Eeg Effects of Imipramine and Chlorpromazine in the Normal and Reserpinized Rabbits

Kamiya¹

1967

Jpn.J.Pharmacol

View full text Add to dashboard Cite

show abstract

“…111 the cat brain, Leclerccl and Segal (3) anti Segal and I,eclercq (4) sho~ved that paceniakers (regions of threshold less than 1 volt) were present within the sal~le susc-eptible areas as reported for the rabbit (1,2). The thresholds for each area were consistent and similar in all animals studied and depended upon the ;tn;ttoniical and histological structure of t h e region stiniulatcd.…”

mentioning

confidence: 66%

Epileptogenic Foci in Rabbit Brain

Leclercq¹,

Segal²

1965

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

Regions highly sensitive to geiierratiilg the ;tfterdisa:hr)rge rcspollse eiist i~a the cortex, rhine11cephaIon. and ~iucleus nicdialis thalami. I he cortical foci lie it] thc deeper regions of the cortex along the border of sepriration between gray nnd white anatter. I'recise electrode placement prcclndes threshold vcariability.'The experililclltal evidence in rabbit correlates with simil;lr cvitlcuce obtaincd in the cat and reported for the guinea pig.

show abstract

“…However, no effect of dilantin on rhinencephalic seizure threshold was reported in rabbit using the stimulation of 30 to 40 c/s with 1 to 7 msec width (22). These negative results might have been accounted by species difference and different route of admi nistration.…”

Section: Discussionmentioning

confidence: 94%

Differential Effects of Antiepileptics on Hippo-Campal and Pallidal Afterdisgharges in Cats

Nakamura

Kurebe

1962

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

The action of anticonvulsant drugs tested by electrical stimulation of the cortex, diencephalon and rhinencephalon in the unanesthetized rabbit

Cited by 57 publications

References 15 publications

Comparative Studies on the Eeg Effects of Imipramine and Chlorpromazine in the Normal and Reserpinized Rabbits

Comparative Studies on the Eeg Effects of Imipramine and Chlorpromazine in the Normal and Reserpinized Rabbits

Epileptogenic Foci in Rabbit Brain

Differential Effects of Antiepileptics on Hippo-Campal and Pallidal Afterdisgharges in Cats

Contact Info

Product

Resources

About