The Action of &amp;lt;i&amp;gt;p&amp;lt;/i&amp;gt;-Synephrine on Lipid Metabolism in the Perfused Rat Liver

Silva-Pereira, Juliany Fontoura da; Valoto, Andrea Luiza de Oliveira; Bracht, Lívia; Gonçalves, Geferson de Almeida; Peralta, Rosane Marina; Bracht, Adelar

doi:10.4236/jbm.2017.55002

Cited by 2 publications

(4 citation statements)

References 24 publications

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“…The overall ATP/ADP ratio was not increased by p ‐synephrine (Figure ), an observation that does not exclude that the mitochondrial ATP/ADP ratio was modified . On the other hand, considering that the increased rate of oxygen uptake caused by p ‐synephrine is mainly consequence of enhanced fatty acid oxidation, it is also reasonable to expect an increased acetyl‐CoA/CoA ratio, which could be one of the main factors responsible for the diminished pyruvate dehydrogenase activity.…”

Section: Discussionmentioning

confidence: 91%

“…Pyruvate dehydrogenase is essential for the complete oxidation of carbohydrates into CO 2 and H 2 O. The increased rates of oxygen uptake caused by p ‐synephrine are thus attributable to an increased oxidation of fatty acids . On the other hand, the pyruvate dehydrogenase step is equally essential for the transformation of carbohydrates into lipids (fatty acids as well as sterols).…”

Section: Discussionmentioning

confidence: 99%

“…In rat adipocytes, maximal stimulation is 4.8‐fold, whereas in human cells, it is equal to 1.98‐fold . In the perfused rat liver, stimulation of the triacylglycerol lipase by p ‐synephrine is less pronounced (only 1.4‐fold) . Much more pronounced is its action on glycogenolysis, glycolysis, and gluconeogenesis .…”

Section: Introductionmentioning

confidence: 97%

“…Glucose release under glycogenolytic conditions is maximally stimulated 3.3‐fold, and the portal concentration for half‐maximal stimulation is equal to 26.1 μ M. Under gluconeogenic conditions, half‐maximal stimulation of glucose release occurs at the concentration of 4.1 μ M . p ‐Synephrine also stimulates hepatic oxygen uptake, but the latter is most probably driven by the oxidation of endogenous fatty acids . All these effects occur in spite of the fact that p ‐synephrine is rapidly transformed in the liver.…”

Section: Introductionmentioning

confidence: 99%

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Actions of p‐synephrine on hepatic enzyme activities linked to carbohydrate metabolism and ATP levels in vivo and in the perfused rat liver

Maldonado

Bracht

Sá‐Nakanishi

et al. 2017

Cell Biochemistry & Function

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p-Synephrine is one of the main active components of the fruit of Citrus aurantium (bitter orange).Extracts of the bitter orange and other preparations containing p-synephrine have been used worldwide to promote weight loss and for sports performance. The purpose of the study was to measure the action of p-synephrine on hepatic enzyme activities linked to carbohydrate and energy metabolism and the levels of adenine mononucleotides. Enzymes and adenine mononucleotides were measured in the isolated perfused rat liver and in vivo after oral administration of the drug (50 and 300 mg/kg) by using standard techniques. p-Synephrine increased the activity of glycogen phosphorylase in vivo and in the perfused liver. It decreased, however, the activities of pyruvate kinase and pyruvate dehydrogenase also in vivo and in the perfused liver.p-Synephrine increased the hepatic pools of adenosine diphosphate and adenosine triphosphate.Stimulation of glycogen phosphorylase is consistent with the reported increased glycogenolysis in the perfused liver and increased glycemia in rats. The decrease in the pyruvate dehydrogenase activity indicates that p-synephrine is potentially capable of inhibiting the transformation of carbohydrates into lipids. The capability of increasing the adenosine triphosphate-adenosine diphosphate pool indicates a beneficial effect of p-synephrine on the cellular energetics. KEYWORDS liver metabolism, metabolic effectors, natural protoalkaloids, sport performance, weight loss effect

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Actions of p‐synephrine on hepatic enzyme activities linked to carbohydrate metabolism and ATP levels in vivo and in the perfused rat liver

Maldonado

Bracht

Sá‐Nakanishi

et al. 2017

Cell Biochemistry & Function

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The Effect of Iron Oxide Nanoparticles of Acalypha wilkesiana Ethyl Acetate Extract on Ehrlich Ascites Carcinoma Cells

Moustafa,

Abd El-Hamid El-Damrany,

Youssef

2023

ACAMC

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Background: Nanoparticles' precise targeting properties are becoming increasingly important in treating cancer and starting to outweigh cancer therapies. Methods: The in vivo anticancer activity of ethyl acetate iron oxide nanoparticles (NPS EAE) of Acalypha wilkesiana Müll. Mosaica was tested using Ehrlich ascites carcinoma cells (EAC). Results: The value of the median lethal dose LD50 limit was found to be 3000 mg/kg. The value count of EAC cells was significantly decreased to 150±2.01 (106) and 275±2.01 (106) cells for each preventive and therapeutic group related to the positive group (525±4.3 (106) cell. Moreover, the results of biological markers decrease in alanine amino transferase activity (ALT), aspartate amino transferase activity (AST), creatinine (CREAT), UREA, albumin, globulin, and total protein level according to the confident group by restoring the abnormal dissimilarity in the biomedical parameters to normal values. Ethyl acetate nano particles induced apoptosis in hepatic and kidney cells. This was designated by increasing the apoptosis regulator Bcl-2 associated X (BAX) level and significantly reducing antiapoptotic assay B-cell lymphoma 2 (Bcl-2) level as an antiapoptotic marker. In the apoptotic marker BAX, there was a significant rise in therapeutic activity with a change of 273.87% and a significant increase in the preventive group with a change of 144.69% according to the positive group. However, in the antiapoptotic marker, Bcl-2 highly decreases in the therapeutic group and preventive group with changes -83.20% and -87.82% according to the positive group, which has a highly significant increase with a change of 5855%. Conclusion: Histopathology tests showed anticancer activity against (EAC) in both the preventive group and therapeutic group, especially in the preventive group in kidney organs showed no pathology with normal glomeruli and normal tubules, it also showed in liver foci of lobular inflammation with mild development of a portal tract accompanied by inflammation, but in the therapeutic group showed less activity than the preventive group as in the kidney many tubules displayed appearances of slight tubular injury with mild acute tubular injury and in the liver, the therapeutic group becomes a more effective representation in normal liver architecture, with no detected lobular or portal inflammation or confluent necrosis. So the preventive group was considered as protecting agent for the kidney organ. However, the therapeutic group is supposed to be the treatment agent for the liver organ. This is due to the fact that it has a defensive effect rather than a curative effect. There is a possibility that it is a favorable anticancer agent. Green synthesis of Fe3O4- NPS was successfully done using plant extract acting as a reducing, stabilizing, and capping agent.

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The Action of <i>p</i>-Synephrine on Lipid Metabolism in the Perfused Rat Liver

Cited by 2 publications

References 24 publications

Actions of p‐synephrine on hepatic enzyme activities linked to carbohydrate metabolism and ATP levels in vivo and in the perfused rat liver

Actions of p‐synephrine on hepatic enzyme activities linked to carbohydrate metabolism and ATP levels in vivo and in the perfused rat liver

The Effect of Iron Oxide Nanoparticles of Acalypha wilkesiana Ethyl Acetate Extract on Ehrlich Ascites Carcinoma Cells

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