“…[10,15] [1,2,4]triazolo [1,5-a] pyridine-8-carbonitrile was prepared from 3- [1,2,4]triazolo [1,5-a]pyridine-8-yl-1,2,4-oxadiazole via the decomposition of oxazolyl moiety when heated to about 200 C (Scheme 1A). [11] 5,7-Dimethyl-2-alkyl(phenyl) [1,2,4]triazolo [1,5-a]pyridine-8-carbonitriles have been reported to obtain for the first time via the recyclization of oxadiazolopyridinium perchlorates when treated with NH 4 OH or NH 4 OAc (Scheme 1B) [16] and then upon cyclocondensation of 1-amino-4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile with carboxamides in the presence of anhydrous ZnCl 2 (Scheme 1C). [12] Our work addresses the issue of construction of such compounds based on one-pot process from 2-(1H-1,-2,4-triazol-5-yl)acetonitriles and β-diketones or β-dialdehydes.…”