2008
DOI: 10.1038/onc.2008.437
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The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC

Abstract: Ezrin is a member of the ERM (ezrin, radixin, moesin) protein family and links F-actin to the cell membrane following phosphorylation. Ezrin has been associated with tumor progression and metastasis in several cancers including the pediatric solid tumors, osteosarcoma and rhabdomyosarcoma. In this study, we were surprised to find that ezrin was not constitutively phosphorylated but rather was dynamically regulated during metastatic progression in osteosarcoma. Metastatic osteosarcoma cells expressed phosphoryl… Show more

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Cited by 116 publications
(135 citation statements)
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References 48 publications
(63 reference statements)
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“…Ren et al 29 has recently shown that the Thr 567-phosphorylated ezrin expression decreased in osteosarcoma metastatic lesions.…”
Section: Discussionmentioning
confidence: 99%
“…Ren et al 29 has recently shown that the Thr 567-phosphorylated ezrin expression decreased in osteosarcoma metastatic lesions.…”
Section: Discussionmentioning
confidence: 99%
“…K7M2 is a metastatic osteosarcoma cell line. These cells express high levels of the cytoskeletal linker protein ezrin, which accounts for the invasive properties of this cell line 13,14 . When HUVEC cells are challenged with K7M2 cells, there is a drop in electrical resistance within 6 hours.…”
Section: Representative Resultsmentioning
confidence: 99%
“…Recent studies suggest that ezrin was dynamically phosphorylated during metastatic progression in osteosarcoma [22]. However, it is currently unclear whether ezrin phosphorylation contributes to the malignancy phenotype of a tumor by promoting tumor cells to internalize NK cells.…”
Section: Discussionmentioning
confidence: 99%