The ACTH test in the diagnosis of hirsutism

Lima, Marco Fábio Prata; Nunes, Márcia Gaspar; Bonduki, Cláudio Emílio; Haidar, Mauro Abi; Lima, Geraldo Rodrigues de; Baracat, Edmund Chada

doi:10.1590/s1516-31801997000200006

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…In normal women, circulating testosterone is linked to b-globulin produced in the liver, sex hormone binding globulin (SHBG) or albumin. Only 1% is detected in the free form 2,4 . However, the free testosterone level is raised in hirsute women [4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, this effect may coexist with normal androgen levels, and result from increased sensitivity of hair follicles to circulating androgens 2,3 . In addition, it is frequently related to idiopathic causes or chronic anovulation 4,5 . However, exogenous hormones and adrenal or ovarian tumors can be other etiologies 4 .…”

Section: Introductionmentioning

confidence: 99%

“…In addition, it is frequently related to idiopathic causes or chronic anovulation 4,5 . However, exogenous hormones and adrenal or ovarian tumors can be other etiologies 4 . In many cases, androgen metabolism, mainly testosterone, can be altered.…”

Section: Introductionmentioning

confidence: 99%

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The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism

Lakryc

Motta

Soares

et al. 2003

Gynecological Endocrinology

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Finasteride has been used frequently in the treatment of prostate hyperplasia, but this drug inhibits 5alpha-reductase and for this reason could be useful for the treatment of hirsutism. The aim of this study was to evaluate the clinical and hormonal effects of finasteride on hirsute women with idiopathic hirsutism or polycystic ovary syndrome. Twenty-four women were randomly divided into two groups: those given placebo and those given finasteride 5 mg/day. The treatment period was 6 months. All patients were evaluated before the beginning of treatment (baseline) and after 3 and 6 months of treatment using clinical examination through Ferriman-Gallwey score, blood pressure, cardiac frequency and body mass index. Also, we collected blood for hormonal determination of levels of prolactin, 17alpha-hydroxyprogesterone, follicle stimulating hormone, luteinizing hormone, total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and dihydrotestosterone. Furthermore, all patients were asked about their concerns and satisfaction with the treatment. The results showed that the Ferriman-Gallwey score in the 6th month of finasteride treatment was significantly lower than at baseline and the 3rd month of this drug treatment. The dihydrotestosterone level in the finasteride group was also significantly reduced compared to that in the placebo group. The other hormones did not show any statistical difference during the study. All the patients treated with finasteride perceived a reduction in hirsutism after 6 months. In conclusion, our data suggest that finasteride may be effective for the treatment of the hirsute woman with idiopathic hirsutism or polycystic ovary syndrome.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism

Lakryc

Motta

Soares

et al. 2003

Gynecological Endocrinology

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Shwachman‐Diamond syndrome

Dror

2005

Pediatric Blood & Cancer

124

155

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Shwachman-Diamond syndrome (SDS) is an inherited marrow failure disorder with varying cytopenia, pancreatic dysfunction, and metaphyseal dysostosis. SDS is also characterized by a risk of myelodysplasia and leukemia in up to one third of the patients. Over the last 5 years, major advances have been made in understanding the bone marrow phenotype. The gene associated with the disease, SBDS, has recently been identified. Herein we provide an update on the clinical features, the hematopoietic defects, and the genetics of the disease as they are currently understood. We also review the diagnostic and therapeutic approaches to the hematological complications in the syndrome.

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The ACTH test in the diagnosis of hirsutism

Cited by 2 publications

References 12 publications

The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism

The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism

Shwachman‐Diamond syndrome

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