The Acquired Immunodeficiency Syndrome in the Wife of a Hemophiliac

Pitchenik, Arthur E.; Shafron, Richard D.; Glasser, Robert M.; Spira, Thomas J.

doi:10.7326/0003-4819-100-1-62

Cited by 75 publications

(6 citation statements)

References 21 publications

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“…[17] did not find any immunological alterations in the female sexual partners of their hemophilic patients. In 1984 the first reports on AIDS [28] and lymphadenopathy [30] in female sexual partners of hemophiliacs were published. After serological tests for HIV had become available, various groups investigated the seroprevalence of HIV in sexual partners of hemophiliacs [15], [18], [22], [2], [3], [14], [23], [6], [13], [24].…”

Section: Discussionmentioning

confidence: 99%

“…Both HIV infection [18] and AIDS [28] were documented in female sexual partners of hemophiliacs only shortly after the beginning of the AIDS epidemic. The aim of our study is to determine the rate of heterosexual HIV-transmission in our hemophilic patients, to determine the clinical course of those infected, and to define possible risk factors associated with the heterosexual transmission of HIV.…”

Section: Abstract: Hemophilia -Human Immunodeficiency Virus -Heterosmentioning

confidence: 99%

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Heterosexual transmission of HIV in hemophiliacs

et al. 1990

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Of 686 hemophiliacs who are being treated at our institution, 402 (59%) are HIV-sero-positive. One hundred seventy-eight heterosexual partners of HIV-infected hemophiliacs have been serologically examined; 19 (11%) are HIV-positive. So far none of the seropositive partners suffers from ARC or AIDS. The rate of heterosexual transmission of HIV is statistically significantly correlated with the CD4+ count of the HIV-infected index patient. No such correlation was found with the index patient's clinical stage or the isolation of HIV from the index patient's blood. Of 39 seronegative female partners who were investigated clinically and immunologically, 17 showed pathologically increased numbers of CD8+ counts. In one case, HIV was transmitted from a female patient with von Willebrand's disease to her husband. As compared to other groups at risk for AIDS, the rate of heterosexual HIV transmission is comparatively low in hemophiliacs. The exact reason for this difference is not yet known. The relevance of the immunopathological findings in seronegative sexual partners of hemophiliacs also remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Section: Abstract: Hemophilia -Human Immunodeficiency Virus -Heterosmentioning

confidence: 99%

Heterosexual transmission of HIV in hemophiliacs

et al. 1990

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“…However, continued follow-up of this group is needed so that accurate counseling can be provided in the future; evidence for infection with HTLV-III via heterosexual transmission is now emerging. [28][29][30] Hemophilic patients given nonheated commercial factor VIII concentrates are at high risk for development of antibody to HTLV-III and associated immunologic abnormalities. Patients given cryoprecipitate prepared from the plasma of Southeastern Wisconsin blood donors appear to be at lower risk.…”

Section: Discussionmentioning

confidence: 99%

HTLV-III serology in hemophilia: Relationship with immunologic abnormalities

Gill

Menitove

Anderson

et al. 1986

The Journal of Pediatrics

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“…Sexual partners of some hemophilic patients have developed AIDS or ARC, or have seroconverted to HTLV-III/LAV [4-61. 4. At least one case of neonatal AIDS has been reported in a child of a hemophilic patient who subsequently developed AIDS himself [7].…”

Section: Introductionmentioning

confidence: 99%

Hemophiliac patient's knowledge and educational needs concerning acquired immunodeficiency syndrome

Hargraves¹,

Jason²,

Chorba³

et al. 1987

American J Hematol

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The Patient Knowledge Assessment Study (PKAS) was conducted among 107 male hemophilic patients, aged 15 to 67 years, at 19 hemophilia treatment centers (HTC). Participants were given a 30-item questionnaire concerning the cause of acquired immunodeficiency syndrome (AIDS), the groups at risk, and modes of transmission. The questionnaire included questions on the participant's status in regard to antibody to human T-lymphotropic retrovirus, type III/lymphadenopathy-associated virus (HTLV-III/LAV), and the meaning of this test result. HTC health-care providers were asked to complete a separate questionnaire containing 17 questions about information given patients concerning their HTLV-III/LAV antibody status and its meaning. Overall, patients had a good base of knowledge about AIDS; however, there were gaps in this knowledge. Twenty-nine percent of patients did not know that spouses of AIDS patients were at risk for AIDS; 47% did not know that sexual partners of persons with hemophilia were at risk; and 32% did not know that hemophilic children were at risk. Further, only 69% understood that antibody-positive individuals had had contact with the AIDS virus. Identifying these and other areas of misunderstanding will provide the information needed to design educational strategies and psychosocial support programs appropriate for the hemophilic population, and which may serve as a model for other populations.

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The Acquired Immunodeficiency Syndrome in the Wife of a Hemophiliac

Cited by 75 publications

References 21 publications

Heterosexual transmission of HIV in hemophiliacs

Heterosexual transmission of HIV in hemophiliacs

HTLV-III serology in hemophilia: Relationship with immunologic abnormalities

Hemophiliac patient's knowledge and educational needs concerning acquired immunodeficiency syndrome

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