The Acoustic Range Electric-magnetic Field Depresses Behavioral Seizure Activity

Abstract

In the present study, we examined the effect of an acoustic range of electric-magnetic field (EMF) on the behavioral manifestation of seizure in genetically epilepsy-prone rats (GEPRs) of Krushinsky-Molodkina strain. A 5-days exposure to EMF (10000 -15000 Hz frequency, 1,5 m/Tesla, during 20 min) resulted in partial or complete suppression of behavior seizure activity in GEPRs. Besides, on the background of EMF, the latency period of the first wild run was increased. On the same conditions, duration of wild run decreased. Audiogenic stimuli obtained in GEPRs changed the ECoG activity of sensomotoral cortex only in audiogenallykindled animals. Findings of this study suggest that the regulation of the behavioral manifestation of seizure in GEPRs does not involve the cortex; it is mainly regulated by brainstem structures. We concluded that acoustic range of EMF could apply for suppression of behavioral manifestation of the seizure. Audiogenic stimuli obtained in GEPRs changed the ECoG activity of sensomotoral cortex only in audiogenally-kindled animals. Findings of this study suggest that the regulation of the behavioral manifestation of seizure in GEPRs does not involve the cortex; it is mainly regulated by brainstem structures. Rostral part of the cortex has a significant role in the manifestation of seizure activity in audiogenly kindling GEPRs. We concluded that acoustic range of EMF could apply for suppression of behavioral manifestation of the seizure.