The acidosis of pulmonary edema

Avery, Wilbur G.; Samet, Philip; Sackner, Marvin A.

doi:10.1016/0002-9343(70)90062-8

Cited by 47 publications

(14 citation statements)

References 11 publications

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“…Agostin evaluated 6 cases of severe pulmonary edema and found respiratory and met abolic acidosis. Ten patients with 'congestive heart fail ure' had hypocapnia and respiratory alkalosis [22], In a retrospective chart review similar to the present report, Avery et al [5] found severe combined respiratory and metabolic acidosis in 55 out of 101 cases (54%) of pulmon ary edema. Aberman and Fulop [6] managed to obtain arterial blood gases in 46 'consecutive' patients before any treatment, including oxygen, was administered.…”

Section: Discussionsupporting

confidence: 72%

“…I n contrast to these latter two series, we found respira tory alkalosis in 71% and metabolic acidosis in 22% of the patients. Avery et al [5] had similar exclusion criteria to our series and reported those patients in whom data were available. Severe combined respiratory and metabolic acidosis (mean pH 7.11) was present in 54%.…”

Section: Discussionmentioning

confidence: 54%

“…Mortality was 33% overall and was not significantly affected by age, sex, CX R changes or ABD. Aberman and Fulop [6] classi fied their 46 patients as hypercapnic (11), eucapnic (12) and hypocapnic (23) but did not assess ABD as reported here and by Avery et al [5]. Acidemia (pH <7.36) had developed in 83% and mortality was 9% (4 patients).…”

Section: Discussionmentioning

confidence: 95%

“…Early reports of this phenomenon have suggested variable changes in pH and pCOi [1,2], and the statement has been made that early acute CPE is accom panied by respiratory alkalosis [3,4], More recently, several reports have emphasized the occurrence of both metabolic and respiratory acidosis [5,6]. In an effort to accommodate all of these reported observations, we pro posed the hypothesis that acute CPE in its earliest and least severe form is associated with respiratory alkalosis.…”

Section: Introductionmentioning

confidence: 99%

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Acid-Base Disturbances in Cardiogenic Pulmonary Edema

O’Donovan

McGowan²,

Lupinacci³

et al. 1991

Nephron

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Eighty-one consecutive cases of uncomplicated cardiogenic pulmonary edema (CPE) were retrospectively graded for severity of chest roentgenogram (CXR) changes and grouped according to primary acid-base abnormalities, either single or mixed. Mean age was 72, 50 male, 31 female. Twenty-three percent had no acid-base disturbances (ABD). Isolated respiratory alkalosis was most common (41%), followed by metabolic acidosis, 22%; metabolic alkalosis, 10%, and respiratory acidosis, 9%. Age, sex, race distribution, morbidity and mortality were not significantly different between the groups. Overall mortality was 17%. Significantly higher mortality was associated with age over 70, pH less than 7.4, and presence of acute myocardial infarction. CXR scores did not correlate with pH, pCO₂ or pO₂, mortality or morbidity. Some patients with the most severe ABDs recovered while others, who had no ABD on presentation, eventually died. Thus, in 81 consecutive episodes of uncomplicated CPE, isolated respiratory alkalosis was the commonest ABD, occurring in 41%. No correlation was found between ABD and severity of CPE, morbidity or mortality.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Acid-Base Disturbances in Cardiogenic Pulmonary Edema

O’Donovan

McGowan²,

Lupinacci³

et al. 1991

Nephron

View full text Add to dashboard Cite

show abstract

“…11 Whether or not there is a causal link between the organic and the 'functional' condition (as has been suggested in subjects with both asthma and hyperventilation) remains to be proven in most cases.…”

mentioning

confidence: 99%