The Acidity of Triphosphoric Acid<sup>1</sup>

Watters, James I.; Loughran, E.D.; Lambert, Sheldon M.

doi:10.1021/ja01600a011

Cited by 45 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sodium triphosphate (technical grade, 85%) was purchased from Aldrich Chemical Co. and was purified by repeated crystallisation from aqueous solution by the addition of methanol. 16…”

Section: Experimental Materialsmentioning

confidence: 99%

Cyclen based bis-macrocyclic ligands as phosphates receptors. A potentiometric and NMR study

et al. 2005

View full text Add to dashboard Cite

The host-guest interaction between orthophosphate, pyrophosphate and triphosphate anions and four cyclen based bis-macrocycles ligands possessing ortho-(BOC), meta-(BMC), para-xylenyl (BPC) or 2,6-pyridinyl (BPyC) linker was investigated by potentiometric measurements and NMR spectroscopy. Each ligand gave protonated species in aqueous solution that further formed ternary complexes after binding with anions; these complexes were analyzed as a result of hydrogen bond formation and Coulombic attraction between the organic host and the inorganic guest. The equilibrium constants for all the detected species are reported and the selectivity, illustrated with species distribution diagrams, is discussed. The results unambiguously showed the importance of the distance between the two cyclen cores and underlined, especially for the triphosphate species, the contribution of the nitrogen atom of the pyridinyl spacer as a supplementary anchoring point in acidic medium.

show abstract

“…Sodium triphosphate (technical grade, 85%) was purchased from Aldrich Chemical Co. and was purified by repeated crystallisation from aqueous solution by the addition of methanol. 16…”

Section: Experimental Materialsmentioning

confidence: 99%

Cyclen based bis-macrocyclic ligands as phosphates receptors. A potentiometric and NMR study

et al. 2005

View full text Add to dashboard Cite

show abstract

“…The crossing linking is dependent on the availability of the cationic sites and the anionic sites. Chitosan is polycationic in acidic environment; TPP has 5 p K a values as follow: , …”

Section: Discussionmentioning

confidence: 99%

Tenofovir Containing Thiolated Chitosan Core/Shell Nanofibers: In Vitro and in Vivo Evaluations

et al. 2016

View full text Add to dashboard Cite

It is hypothesized that thiolated chitosan (TCS) core/shell nanofibers (NFs) can enhance the drug loading of tenofovir, a model low molecular weight and highly water-soluble drug molecule, and improve its mucoadhesivity and in vivo safety. To test this hypothesis, poly(ethylene oxide) (PEO) core with TCS and polylactic acid (PLA) shell NFs are fabricated by a coaxial electrospinning technique. The morphology, drug loading, drug release profiles, cytotoxicity and mucoadhesion of the NFs are analyzed using scanning and transmission electron microscopies, liquid chromatography, cytotoxicity assays on VK2/E6E7 and End1/E6E7 cell lines and Lactobacilli crispatus, fluorescence imaging and periodic acid colorimetric method, respectively. In vivo safety studies are performed in C57BL/6 mice followed by H&E and immunohistochemical (CD45) staining analysis of genital tract. The mean diameters of PEO, PEO/TCS, and PEO/TCS-PLA NFs are 118.56, 9.95, and 99.53 nm, respectively. The NFs exhibit smooth surface. The drug loading (13%-25%, w/w) increased by 10-fold compared to a nanoparticle formulation due to the application of the electrospinning technique. The NFs are noncytotoxic at the concentration of 1 mg/mL. The PEO/TCS-PLA core/shell NFs mostly exhibit a release kinetic following Weibull model (r = 0.9914), indicating the drug release from a matrix system. The core/shell NFs are 40-60-fold more bioadhesive than the pure PEO based NFs. The NFs are nontoxic and noninflammatory in vivo after daily treatment for up to 7 days. Owing to their enhanced drug loading and preliminary safety profile, the TCS core/shell NFs are promising candidates for the topical delivery of HIV/AIDS microbicides such as tenofovir.

show abstract

“…200 g TriP was dissolved in 900 ml H 2 0 and precipitated by adding 330 ml methanol. This procedure was repeated four times and the final product was 99 % pure tripolyphosphate (15). 5 g of the purified tripolyphosphate and 250 mg SnCl 2 • 2 H 2 0 were dissolved in water and the pH was adjusted to 6.8 with 0.1 N HCl.…”

Section: Methodsmentioning

confidence: 99%

Relationship between Complex Stability and Biokinetics of 99mTc-Phosphate Compounds

Schümichen¹,

Körfgen²,

Hoffmann³

1980

Nuklearmedizin

View full text Add to dashboard Cite

The complex inertness of 99mTc-EHDP, -MDP, -PPi and -TriP was determined in vitro by means of protein binding of 99mTc after dilution in a phosphate-buffered albumin solution. Commercially available kits were used. In vitro, 99mTc- EHDP was found to be the most stable complex. The biodistribution of these agents was evaluated in the adult rat; here the less stable 99mTc-MDP proved to be the superior bone imaging agent. It is suggested that the complex inertness and the bone affinity are opposing properties of the 99mTc-phosphate compounds, because the complex must hydrolyse before the phosphate compound and technetium (IV) are deposited separately in bone. Hence, bone imaging with 99mTc-phosphate compounds demands a compromise concerning the stability of these complexes at low ligand concentrations, which among the investigated agents is best accomplished by 99mTc-MDP.

show abstract

The Acidity of Triphosphoric Acid¹

Cited by 45 publications

References 0 publications

Cyclen based bis-macrocyclic ligands as phosphates receptors. A potentiometric and NMR study

Cyclen based bis-macrocyclic ligands as phosphates receptors. A potentiometric and NMR study

Tenofovir Containing Thiolated Chitosan Core/Shell Nanofibers: In Vitro and in Vivo Evaluations

Relationship between Complex Stability and Biokinetics of 99mTc-Phosphate Compounds

Contact Info

Product

Resources

About

The Acidity of Triphosphoric Acid1

Cited by 45 publications

References 0 publications

Cyclen based bis-macrocyclic ligands as phosphates receptors. A potentiometric and NMR study

Cyclen based bis-macrocyclic ligands as phosphates receptors. A potentiometric and NMR study

Tenofovir Containing Thiolated Chitosan Core/Shell Nanofibers: In Vitro and in Vivo Evaluations

Relationship between Complex Stability and Biokinetics of 99mTc-Phosphate Compounds

Contact Info

Product

Resources

About

The Acidity of Triphosphoric Acid¹