The acetylcholine receptors of Renshaw cells

A Re‐evaluation of Acetylcholine Receptors on Feline Renshaw Cells

“…As found in a previous study (Curtis & Ryall,1 A ntagonists DH,E very effectively antagonized the excitatory effect of acetylcholine when the former was ejected with currents of about 10 nA from 2.5 or 10mM solutions, as found in previous studies (Curtis & Ryall, 1966b). DHI3E did not block excitation by DLH.…”

“…Since DH,$E did not affect a component of excitation with acetyl-,8-methylcholine which was effectively blocked by atropine (Curtis & Ryall,1 966b) & Ryall, 1966b). It would also explain the complete block of ACh and nicotine by atropine-like substances and the partial block of the early synaptic discharge observed in this investigation, together with the virtually complete block of all of these responses by DH/3E.…”

“…DHI3E did not block excitation by DLH. It does not antagonize a muscarinic component of the excitatory action of acetyl-,-methylcholine (Curtis & Ryall, 1966b) and it facilitates the late discharge of Renshaw cells evoked by antidromic ventral root volleys (Curtis & Ryall, 1966c;Ryall, 1970). It was observed that atropine consistently and selectively blocked the excitatory action of ACh, leaving excitation by DLH unaffected (Figures 1, 2).…”

“…It was observed that atropine consistently and selectively blocked the excitatory action of ACh, leaving excitation by DLH unaffected (Figures 1, 2). This observation was rather surprising because it has been concluded (Curtis & Ryall, 1966b) that the major effect of ACh was due to an interaction with nicotinic receptors on Renshaw cells in the cat. The effect was not restricted to atropine, but was also observed with methyl-atropine, one of the other antagonists at muscarinic receptors employed in this study: on 16/20 cells tested with either of these two substances the response to ACh but not to DLH was reduced.…”

Histamine and Some Antihistamines: Their Actions on Cerebral Cortical Neurones

“…The noradrenaline receptors mediating this excitation were also prone to desensitization when the drug was applied repeatedly. Excitant and depressant effects of choline esters upon the same thalamic neurone (McCance, Phillis, TebEcis & Westerman, 1968) and Renshaw cells (Curtis & Ryall, 1966) have been described. This phenomenon has recently been given considerable significance with the discovery of a neurone in Aplysia that is both excited and inhibited by synaptically released ACh (Wachtel & Kandel, 1967).…”