The Acetone Extract of<i>Sclerocarya birrea</i>(Anacardiaceae) Possesses Antiproliferative and Apoptotic Potential against Human Breast Cancer Cell Lines (MCF-7)

Tanih, Nicoline F.; Ndip, Roland N.

doi:10.1155/2013/956206

Cited by 31 publications

(25 citation statements)

References 24 publications

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“…Therefore, the DNA patterns produced in this study were similar to that presented by Gao et al (2002) who reported that resveratrol from plant extract induced DNA fragmentation in 32Dp210 leukemic cells. On the other hand, the obtained DNA fragmentation result in this study is contrary to the finding of Tanih and Ndip (2013) who reported that apoptosis induction was detected by conversion of intense DNA band to faint band with no DNA fragmentation.…”

Section: Gene Expressioncontrasting

confidence: 99%

Antimicrobial and Anticancer Activities of Extracts From Urginea Maritima Fruits

Obeidat¹,

Sharab²

2017

AJTCAM

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Background: Increasing antibiotic resistance among human pathogenic microorganisms and the failure of conventional cancer therapies attracting great attention among scientists in the field of herbal medicine to develop natural antimicrobial and anticancer drugs. Thus, the antimicrobial and anticancer activities from fruits of the medicinal plant Urginea maritima (L.) Baker that unexplored previously were investigated in this study. Materials and Methods: Fruits of U. maritima plant were collected, dried, ground, and extracted by hot water, ethanol, methanol, and acetone. The fruit extracts were examined for their potential as antimicrobial and anticancer agents using the agar well diffusion method and MTT assay, respectively. The gene expression of some cancer-related gene markers was determined by RT-PCR. Results: All fruit extracts of U. maritima exhibited antibacterial activity against S. aureus and E. coli. Methanol and ethanol extracts exhibited anticandidal activity. Ethanol and acetone extracts displayed non-hemolytic activity and selective cytotoxicity against breast cancer MCF7 cells with IC 50 values that considered as active treatments. Concerning DNA fragmentation and gene expression after treatment of MCF7 cells with the most promising acetone extract, induction of apoptosis was proposed. The expression of cancer-related gene TNF after 6 hours, tumor suppressor genes (p53 and BRCA1), and immune response genes (IL-2 and IL-6) was induced. The expression of antiapoptotic gene Bcl2 in treated MCF7 cells was reduced. Conclusion: Fruit extracts of U. maritima exhibited antimicrobial and anticancer activities. This result may lead to the use of these extracts for treatment of some infectious diseases and certain types of cancer.

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Section: Gene Expressioncontrasting

confidence: 99%

Antimicrobial and Anticancer Activities of Extracts From Urginea Maritima Fruits

Obeidat¹,

Sharab²

2017

AJTCAM

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“…The species also has several non-medical cultural values, including myths and beliefs, ornamentation, food, handicrafts and wood [13] [21] [22]. Recently, the anticancer [25], anti-microbial (respiratory infections) [26], anti-diabetic and anti-oxidant ability of S. birrea [27] as well as a set of compounds and molecules related to these diseases [28] have been reported. In addition, the fruits of this species are highly nutritive, with unusually high contents of micronutrients, protein (ca.…”

Section: Bark Use Surveymentioning

confidence: 99%

Bark Stripping from Forest Tree Species in Madjadjane, Southern Mozambique: Medicinal Uses and Implications for Conservation

Senkoro

Barbosa²,

Moiane³

et al. 2014

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Tree bark is one of the most important non-timber forest products. In less developed countries, it is used for multiple purposes, particularly in traditional medicine. This paper addresses the question of bark exploitation, uses, and impacts in Madjadjane village, southern Mozambique. For that, we have conducted an ethnobotanical survey and analysed the level of damage of the ten most exploited tree species. Bark was mainly used for medical purposes, spanning 13 different applications. Most of the species had more than one medical application constituting potential sources of valuable biocompounds. In general the level of damage caused by debarking was not critical, but should be seen with caution. An upgrade and update of the results will be of utmost importance to estimate with more accuracy the current conservation status as well as to predict future impacts and define better conservation strategies. We suggest the expansion of ethnobotanical surveys as well as their integration in broad programs aimed at the preservation and valorization of local heritage. This will encourage equitable access and benefit sharing of biodiversity as well as the promotion of bio-based economy.

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“…Tanih have shown that acetone extracts of Sclerocarya birrea have apoptotic activity against the human breast cancer cell line MCF-7 [8,9]. Similar anti-microbial results were obtained with boiling organics such as Triton X-100 and chloroform in a broad spectrum of Gram Positive and Gram Negative cells, including Mycobacterium [10].…”

Section: Anti-microbial Effectsmentioning

confidence: 81%

Preparation of Drugs in the Developing World

Schultz¹

2017

Gen Int Med Clin Innov

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The Acetone Extract ofSclerocarya birrea(Anacardiaceae) Possesses Antiproliferative and Apoptotic Potential against Human Breast Cancer Cell Lines (MCF-7)

Cited by 31 publications

References 24 publications

Antimicrobial and Anticancer Activities of Extracts From Urginea Maritima Fruits

Antimicrobial and Anticancer Activities of Extracts From Urginea Maritima Fruits

Bark Stripping from Forest Tree Species in Madjadjane, Southern Mozambique: Medicinal Uses and Implications for Conservation

Preparation of Drugs in the Developing World

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