The Accuracy of Tissue Resonance Interaction Method Probe (Trimprob Tm) in Non-Invasive Diagnosis of Prostatic Cancer. Analysis of the Results of 782 Patients

Viccaro, D. Di; Perugia, G.; Cerulli, C.; Olivieri, Valerio; Bova, G.; Balla, J.; Zanza, Christian; Teodonio, S.; Liberti, M.

doi:10.1177/039156030907604s01

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…These results have subsequently been replicated by other studies [6–8] and even by a multicenter trial [5], thus supporting also the reproducibility of the technique in detecting prostate cancer.…”

Section: Discussionsupporting

confidence: 69%

“…Bellorofonte et al [ 4 ] were the first to evaluate the feasibility and diagnostic accuracy of TRIM-prob scanning in detecting prostate cancer; in their study population of 757 men, the test had a 95.5% sensitivity, a 42.7% specificity, a 63.6% PPV, and an 89.8% NPV. These results have subsequently been replicated by other studies [ 6 – 8 ] and even by a multicenter trial [ 5 ], thus supporting also the reproducibility of the technique in detecting prostate cancer.…”

Section: Discussionsupporting

confidence: 69%

“…Briefly, the device generates an alternating electromagnetic field that interacts with charged particles (molecules, ions, electrons, and nuclei) in a target tissue leading to a secondary radiation that varies for normal and neoplastic biological tissues [ 3 ]. Several pilot clinical studies have shown that TRIM-prob scanning may be a valuable tool in diagnosing prostate [ 4 – 8 ], breast [ 9 ], gastric [ 10 ], thyroid [ 11 ], rectum [ 12 ], and even bladder cancer [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive Electromagnetic Detection of Bladder Cancer

et al. 2014

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Objectives. Normal and neoplastic human tissues have different electromagnetic properties. This study aimed to determine the diagnostic accuracy of noninvasive electromagnetic detection of bladder cancer (BC) by the tissue-resonance interaction method (TRIM-prob). Patients and Methods. Consecutive patients were referred for cystoscopy because of (i) microscopic or gross hematuria and/or irritative voiding symptoms and (ii) bladder ultrasounds and urinary cytology findings negative or just suspicious of malignancy. Patients were first submitted to TRIM-prob bladder scanning by a single investigator and then to cystoscopy by another investigator blind to TRIM-prob data. Results. In 125 evaluated patients cystoscopy was positive for BC in 47 and negative in the remaining 78; conversely, TRIM-prob bladder scanning was positive for BC in 53 and negative in 72. In particular, TRIM-prob scanning yielded 7 false positives and only one false negative; therefore, its overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 97.9%, 89.9%, 86.8%, 98.6%, and 93.6%, respectively. Conclusions. TRIM-prob bladder scanning was a simple and quite accurate method for non-invasive electromagnetic detection of BC. If the elevated positive and negative predictive values will be replicated in further well-designed studies, it could be used to screen asymptomatic patients at high risk of BC.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Noninvasive Electromagnetic Detection of Bladder Cancer

et al. 2014

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“…The receiver of the TRIMprob detects the signal originating from non-linear resonance interactions of intensity expressed in arbitrary units ranging between 0 and 255. TRIMprob is a simple, quick to perform (in this study examination took less than 5 min) test that does not require any prior preparation of the patient, yielding immediate and reproducible results [ 5 , 6 , 11 ]. Previous clinical studies have shown that TRIMprob scanning is useful in detecting cancers of different localisations.…”

Section: Discussionmentioning

confidence: 99%

“…Using a wave frequency equal to half of the microtubule length was found to optimally detect cancerous growth. Several pilot clinical studies have shown that TRIMprob scanning is a valuable tool in diagnosing cancers developing in prostate [ 7 – 11 ], breast [ 12 ], stomach [ 13 ], thyroid gland [ 14 ], rectum [ 15 ], colon [ 16 ], or urinary bladder [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of hepatocellular carcinoma by tissue resonance interaction method (TRIM)

Boryczka

Hartleb

Janik

2018

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IntroductionDiagnosis of hepatocellular carcinoma (HCC) is considerably delayed, being frequently done in the non-curative stage of disease. The reason for delayed diagnosis is indolent course in early stages and/or unspecific symptoms indistinguishable from underlying cirrhosis. Hitherto methods used for screening of HCC have important limitations. TRIMprob is a non-invasive method, which showed utility in detection of cancers located in prostate, breast, or urinary bladder.AimTo determine the diagnostic accuracy of TRIMprob in detecting HCC in cirrhotic liver.Material and methodsForty-five patients were prospectively enrolled according to final clinical diagnosis into a group of cirrhosis and HCC or a group of cirrhosis without HCC. A control group consisted of 33 healthy subjects. Hepatocellular carcinoma was diagnosed by computed tomography (CT) or magnetic resonance (MR) and guided biopsy. The TRIMprob examination was performed in each patient. Three wave frequencies were used: 465, 930, and 1395 MHz.ResultsIn patients with HCC the intensity of return signal using wave a frequency of 465 MHz was significantly reduced in patients with HCC in comparison to healthy subjects (p < 0.0005), but not to cirrhotic patients without HCC. Moreover, cirrhosis was associated with significantly decreased TRIMprob signal in comparison to healthy liver (p < 0.002). In ROC analysis an optimal cut-off value for detection of HCC was 106 units, which yielded 80% sensitivity.ConclusionsTRIMprob identifies HCC with good sensitivity; however, the accuracy of this method to identify HCC in screening circumstances may be hindered by attenuation of the resonance interaction signal by cirrhosis itself.

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Dielectric characterization of healthy and malignant colon tissues in the 0.5–18 GHz frequency band

et al. 2016

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Several reports over the last few decades have shown that the dielectric properties of healthy and malignant tissues of the same body organ usually show different values. However, no intensive dielectric studies of human colon tissue have been performed, despite colon cancer's being one of the most common types of cancer in the world. In order to provide information regarding this matter, a dielectric characterization of healthy and malignant colon tissues is presented. Measurements are performed on ex vivo surgery samples obtained from 20 patients, using an open-ended coaxial probe in the 0.5-18 GHz frequency band. Results show that the dielectric constant of colon cancerous tissue is 8.8% higher than that of healthy tissues (p = 0.002). Besides, conductivity is about 10.6% higher, but in this case measurements do not have statistical significance (p = 0.038). Performing an analysis per patient, the differences in dielectric constant between healthy and malignant tissues appear systematically. Particularized results for specific frequencies (500 MHz, 900 MHz, 2.45 GHz, 5 GHz, 8.5 GHz and 15 GHz) are also reported. The findings have potential application in early-stage cancer detection and diagnosis, and can be useful in developing new tools for hyperthermia treatments as well as creating electromagnetic models of healthy and cancerous tissues.

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The Accuracy of Tissue Resonance Interaction Method Probe (Trimprob Tm) in Non-Invasive Diagnosis of Prostatic Cancer. Analysis of the Results of 782 Patients

Cited by 5 publications

References 5 publications

Noninvasive Electromagnetic Detection of Bladder Cancer

Noninvasive Electromagnetic Detection of Bladder Cancer

Detection of hepatocellular carcinoma by tissue resonance interaction method (TRIM)

Dielectric characterization of healthy and malignant colon tissues in the 0.5–18 GHz frequency band

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