The accuracy of the sentinel lymph node concept in early stage squamous cell vulvar carcinoma

Radziszewski, Jakub; Kowalewska, Magdalena; Jędrzejczak, Tomasz; Kozłowicz-Gudzińska, Izabella; Nasierowska‐Guttmejer, Anna; Bidziński, Mariusz; Siedlecki, Janusz A.

doi:10.1016/j.ygyno.2009.10.072

Cited by 47 publications

(22 citation statements)

References 30 publications

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“…In such cases, only the sensitivity and specificity results can be given for the combination of tests used rather than only blue dye or 99m Tc separately or only both used together in all patients. However, for the other 20 studies, 50,51,[53][54][55][56][57][58][59][60][61][63][64][65][68][69][70][71][72][73][74] detection rates per groin can be given for each test separately and both tests combined (see Table 7). It is noticeable that the histopathological techniques used for the full IFL specimens were either not given or were less detailed than those used for the SLNs.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…It is noticeable that the histopathological techniques used for the full IFL specimens were either not given or were less detailed than those used for the SLNs. Only De Cicco et al, 55 Johann et al 59 and Radziszewski et al 68 appeared to use the same techniques and very little detail is given in the first two. More details of index tests and reference standards used are given in Appendix 10.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Sentinel lymph node status in vulval cancer: systematic reviews of test accuracy and decision-analytic model-based economic evaluation

Meads¹,

Sutton²,

Małysiak³

et al. 2013

Health Technology Assessment

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Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Sentinel lymph node status in vulval cancer: systematic reviews of test accuracy and decision-analytic model-based economic evaluation

Meads¹,

Sutton²,

Małysiak³

et al. 2013

Health Technology Assessment

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“…Lymphatic mapping with 99m technetium labelled colloidal albumin either alone or in combination with blue dye yields generally better detection rates (89-100%) than the use of blue dye alone (56-95%). 13,[23][24][25][26][27] Other authors have used solely radioactive tracer for mapping and achieved high detection rates between 98% and 100% (table 3). According to these data the addition use of blue dye appears to be of limited benefit.…”

Section: Limitations Of Our Findingsmentioning

confidence: 99%

Sentinel lymph node detection in patients with vulvar carcinoma; Feasibility of intra-operative mapping with technetium-99m-labeled nanocolloid

Klar

Bossart

Stickeler

et al. 2011

European Journal of Surgical Oncology (EJSO)

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To cite this version:M. Klar, M. Bossart, E. Stickeler, I. Brink, M. Orlowska-Volk, et al.. Sentinel lymph node detection in patients with vulvar carcinoma; Feasibility of intraoperative mapping with technetium-99m-labeled nanocolloid. EJSO -European Journal of Surgical Oncology, WB Saunders, 2011, 37 (9) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT Key words /MeSH terms:Vulvar carcinoma, sentinel lymph node, technetium-99m nanocolloid Conflict of interestThe authors declare no conflict of interest M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 3 Abstract Aims:Sentinel lymph node (SLN) mapping appears to be feasible in patients with primary vulvar cancer. Previous protocols describe the injection of the technetium-99m-nanocolloid at least 3 hours before surgery which involves two invasive procedures for the patient. In this study, we assessed the feasibility, safety, and accuracy of an intraoperative rather than preoperative SLN mapping in patients with primary vulvar cancer. Methods:Patients with histologically confirmed squamous cell vulvar cancer and clinically FIGO stage Ib disease underwent intraoperative SLN mapping by intradermal injection of the nanocolloid around the tumor. SLN were identified and removed before a complete inguino-femoral lymphnode dissection was performed. Surgical and pathologic data on all patients were prospectively entered into a database. Results:A SLN procedure was performed in 16 patients; 3 patients received unilateral lymphadenectomy, and 13 women underwent surgery on both groins. In all groins but 4 at least one SLN was clearly identified (detection rate 25/29, 86%). A median number of 2 SLN and 4 non-SLN per groin were removed. 3 of 16 patients (19 %) had metastatic disease in the lymph nodes. There was no false negative SLN result. Conclusion:Intraoperative SLN detection seems feasible in patients with early stage vulvar cancer. More patients need to be enrolled in this ongoing study before this more convenient technique can be considered safe.

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“…This minimally invasive procedure allows selective ablation of the first draining tumor node, thereby permitting a less aggressive inguinal surgery. Published results are promising [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Video endoscopic-assisted inguino-femoral lymphadenectomy (VEIL) in squamous cell invasive vulvar carcinoma: our initial experience

2011

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Inguinal lymphadenectomy is a part of the surgical treatment of invasive perineal cancers and lower extremities and inferior trunk melanomas. Inguinal node metastasis represents a major prognostic factor; therefore, inguinal lymphadenectomy has a central role in oncological patient management. Nevertheless, inguinal node dissection is associated with significant morbidity such as lymphedema, wound dehiscence, flap necrosis, infection, seroma, femoral hernia, and deep venous thromboembolism. Recently, several publications have reported experiences with video endoscopicassisted techniques attempting to reduce the high morbidity related to open inguinal lymphadenectomy. The primary results are promising in terms of feasibility, oncological survey and goals, postoperative complications, and esthetic results. We discuss here our initial experience with video endoscopic inguino-femoral lymphadenectomy (VEIL) in a patient with invasive vulvar carcinoma. To our knowledge, this is the first report of a bilateral VEIL in vulvar carcinoma.

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The accuracy of the sentinel lymph node concept in early stage squamous cell vulvar carcinoma

Cited by 47 publications

References 30 publications

Sentinel lymph node status in vulval cancer: systematic reviews of test accuracy and decision-analytic model-based economic evaluation

Sentinel lymph node status in vulval cancer: systematic reviews of test accuracy and decision-analytic model-based economic evaluation

Sentinel lymph node detection in patients with vulvar carcinoma; Feasibility of intra-operative mapping with technetium-99m-labeled nanocolloid

Video endoscopic-assisted inguino-femoral lymphadenectomy (VEIL) in squamous cell invasive vulvar carcinoma: our initial experience

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