The Accuracy of Large Loop Excision of the Transformation Zone Specimen Dimensions in Determining Volume: A Multicentric Prospective Observational Study

Carcopino, Xavier; Mancini, Julien; Prendiville, Walter; Gondry, J.; Chevreau, Julien; Lamblin, G.; Atallah, Anthony; Lavoué, Vincent; Caradec, Claire; Baldauf, Jean-Jacques; Bryand, Angélique; Henno, Sébastien; Agostini, Aubert; Douvier, S.; Jarniat, Adélaide; Riethmuller, Didier; Mendel, Anne; Brun, Jean‐Luc; Rakotomahenina, H; Préaubert, Lise

doi:10.1097/lgt.0000000000000283

Cited by 4 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The volume was estimated according to the formula proposed by Carcopino (7) the circumference corresponds to the external circumference of the cone, the length represents the distance from the external/distal margin to the internal/proximal margin of the open sample and the thickness was defined as the distance from the stromal margin to the surface of the epithelium. The volume of the cone was calculated using the hemielipsoid formula :…”

Section: Volume Of the Operating Piecementioning

confidence: 99%

Impact of Conization Type, Cone Volume and Dimensions on the Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3

Medina Bueno,

Fernández-Montolí,

Ponce Sebastià

et al. 2023

Preprint

View full text Add to dashboard Cite

Objectives: To evaluate the relationship between the type of conization, the volume and dimensions of the cone, with the persistence/recurrence of CIN 2-3, presence of affected margins and post-cone HR-HPV positivity. Methods: 227 women treated with LLETZ and histologically confirmed CIN2-3 were evaluated between 1996 and 2006 and followed up until June 2016. Age, type of resection according to IFCPC 2011, volume, cone dimensions, margins were studied. of resection, post-cone high-risk human papillomavirus (HR-HPV) status and viral load. Determinants of HR-HPV positivity were estimated using unconditional logistic regression and time to recurrence was assessed using Kaplan-Meier curves. Results: Persistent/recurrent CIN2-3 was found in 12 cases (5.2%), type 1 conization was performed in 81 patients, with 5 recurrences (6.1%), type 2 in 101 patients, with 6 recurrences (5 .9%) and type 3 resection in 45 women, with 1 recurrence (2.2%). Volume and dimensions were not associated with recurrence. The Log-Rank Test did not show a significant difference between the 3 treatments (p= 0.18). The free margins in type 1 were 37%, in type 2 resection 61% and in type 3 71% (p=0.001). Resection type 1 had 15% HR-HPV post positive cone, type 2 reached 16% and type 3 had 9%, this difference being non-significant (p=0.58). The incidence of recurrence at 36 months in type 1 resection was 0.08%, in type 2 treatment it was 0.04% and in type 3 resection it was 0.0%. Conclusions : Type 3 resection had a higher proportion of free margins and lower post-cone HR-HPV positivity, with a lower incidence of persistence/recurrence.

show abstract

Section: Volume Of the Operating Piecementioning

confidence: 99%

Impact of Conization Type, Cone Volume and Dimensions on the Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3

Medina Bueno,

Fernández-Montolí,

Ponce Sebastià

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Although volume formulas for several shapes have previously been used to measure cone volume, including the cone, the parallelepiped, and the frustum (truncated cone), the semi-ellipsoid is a more accurate depiction of the true curvature of the proximal side of the cone. 65 Furthermore, the Series semi-ellipsoid calculation only requires three dimensions that are measured routinely (anteroposterior dimension, transverse dimension, and length). Different formulas can be used based on clinical judgement if different cone shapes are present (appendix pp 7-8).…”

Section: Cone Dimensions and Volumementioning

confidence: 99%

Terminology for cone dimensions after local conservative treatment for cervical intraepithelial neoplasia and early invasive cervical cancer: 2022 consensus recommendations from ESGO, EFC, IFCPC, and ESP

Kyrgiou

Athanasiou²,

Arbyn³

et al. 2022

The Lancet Oncology

Self Cite

View full text Add to dashboard Cite

Risk Factors of Post-Large Loop Excision of the Transformation Zone Recurrent High-Grade Cervical Intraepithelial Lesion: A Prospective Cohort Study

Demarquet

Mancini

Préaubert

et al. 2019

J Low Genit Tract Dis

View full text Add to dashboard Cite

show abstract

The Accuracy of Large Loop Excision of the Transformation Zone Specimen Dimensions in Determining Volume: A Multicentric Prospective Observational Study

Abstract: The hemiellipsoid formula is the most accurate determinant of the excised volume. Other formulas do not allow for an accurate estimation of the excised volume.

Cited by 4 publications

References 14 publications

Impact of Conization Type, Cone Volume and Dimensions on the Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3

Impact of Conization Type, Cone Volume and Dimensions on the Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3

Terminology for cone dimensions after local conservative treatment for cervical intraepithelial neoplasia and early invasive cervical cancer: 2022 consensus recommendations from ESGO, EFC, IFCPC, and ESP

Risk Factors of Post-Large Loop Excision of the Transformation Zone Recurrent High-Grade Cervical Intraepithelial Lesion: A Prospective Cohort Study

Contact Info

Product

Resources

About