The accuracy of 1- and 3-mm slices in coronary calcium scoring using multi-slice CT in vitro and in vivo

Mühlenbruch, Georg; Klotz, Ernst; Wildberger, Joachim E.; Koos, Ralf; Das, Marco; Niethammer, M.; Hohl, C.; Honnef, Dagmar; Thomas, Christoph; Günther, Rolf W.; Mahnken, Andreas H.

doi:10.1007/s00330-006-0332-0

Cited by 30 publications

(29 citation statements)

References 37 publications

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“…It has previously been established that high-resolution CT (HRCT) using a thin slice thickness and a high spatial frequency algorithm should be applied to lung imaging to improve spatial resolution [16,17]. However, using a thin slice thickness and a high spatial frequency algorithm increases the visible image noise [17][18][19]. We believe that ASIR is the ideal algorithm for HRCT of the lung to reduce image noise and to obtain better image quality.…”

Section: Discussionmentioning

confidence: 99%

Image quality of multiplanar reconstruction of pulmonary CT scans using adaptive statistical iterative reconstruction

Honda¹,

Yanagawa²,

Kikuyama³

et al. 2011

BJR

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Objective: We investigated the image quality of multiplanar reconstruction (MPR) using adaptive statistical iterative reconstruction (ASIR). Methods: Inflated and fixed lungs were scanned with a garnet detector CT in highresolution mode (HR mode) or non-high-resolution (HR) mode, and MPR images were then reconstructed. Observers compared 15 MPR images of ASIR (40%) and ASIR (80%) with those of ASIR (0%), and assessed image quality using a visual five-point scale (1, definitely inferior; 5, definitely superior), with particular emphasis on normal pulmonary structures, artefacts, noise and overall image quality. Results: The mean overall image quality scores in HR mode were 3.67 with ASIR (40%) and 4.97 with ASIR (80%). Those in non-HR mode were 3.27 with ASIR (40%) and 3.90 with ASIR (80%). The mean artefact scores in HR mode were 3.13 with ASIR (40%) and 3.63 with ASIR (80%), but those in non-HR mode were 2.87 with ASIR (40%) and 2.53 with ASIR (80%). The mean scores of the other parameters were greater than 3, whereas those in HR mode were higher than those in non-HR mode. There were significant differences between ASIR (40%) and ASIR (80%) in overall image quality (p,0.01). Contrast medium in the injection syringe was scanned to analyse image quality; ASIR did not suppress the severe artefacts of contrast medium. Conclusion: In general, MPR image quality with ASIR (80%) was superior to that with ASIR (40%). However, there was an increased incidence of artefacts by ASIR when CT images were obtained in non-HR mode. Multiplanar reconstruction (MPR) of CT images plays an important role in the interpretation of the threedimensional anatomical location or extent of disease, and is an essential technique in daily clinical practice. Multidetector row CT (MDCT) is widely used, and advances in MDCT technology have facilitated better images with thinner slice thickness and extended coverage, which has allowed more MPR images to be evaluated in greater detail. Coronal MPR images produced by MDCT supply good image quality for lung assessment and show similar image quality to axial highresolution (HR) CT images [1, 2].To further enhance CT image quality, improvements in temporal resolution and/or spatial resolution are needed. MDCT equipped with more rapid gantry rotation or more detector arrays has already evolved for the improvement of temporal resolution. GE Healthcare (Milwaukee, WI) recently produced an MDCT unit containing a new detector composed of garnet, which has a faster response than the previous detector material. This apparatus can provide improved spatial resolution by acquiring more data.Reconstruction algorithms are also important for improved image quality. Although the filtered backprojection algorithm has traditionally been used for image reconstruction, new reconstruction algorithms are being developed. The iterative reconstruction algorithm has already been used for image reconstruction of positron emission tomography (PET) or single photon emission CT (SPECT), resulting in improved image quality [3][4...

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Section: Discussionmentioning

confidence: 99%

Image quality of multiplanar reconstruction of pulmonary CT scans using adaptive statistical iterative reconstruction

Honda¹,

Yanagawa²,

Kikuyama³

et al. 2011

BJR

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“…The drawback is requiring a high radiation dose to maintain the image quality needed. Mühlenbruch et al showing similar calcium scoring results of 1-mm and 3-mm slices, conclude that 'the potentially necessary increase of the patient's dose in order to achieve assessable 1-mm slices with an acceptable image-to-noise ratio appears not to be justified' [31].…”

Section: Interobserver Variabilitymentioning

confidence: 96%

Variability of repeated coronary artery calcium measurements by 1.25-mm- and 2.5-mm-thickness images on prospective electrocardiograph-triggered 64-slice CT

et al. 2007

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High reproducibility on coronary artery calcium scoring is a key requirement in monitoring the progression of coronary atherosclerosis. The purpose of this prospective study is to assess the reproducibility of 1.25-mm- and 2.5-mm-thickness images on prospective electrocardiograph-triggered 64-slice CT with respect to 2.5-mm-thickness images on spiral overlapping reconstruction. One hundred patients suspected of coronary artery disease were scanned twice repeatedly, both on prospective electrocardiograph-triggered step-and-shoot and retrospective electrocardiograph-gated spiral scans. Using 1.25-mm-thickness collimation, 1.25-mm- and 2.5-mm-thickness image sets on prospective scans and 2.5-mm-thickness image sets with 1.25-mm increment (overlapping) on retrospective scans were obtained. Coronary artery calcium scores, interscan variability and interobserver variability were evaluated. The mean interscan variability in coronary artery calcium measurement on 1.25-mm prospective/2.5-mm prospective/2.5-mm overlapping retrospective scans were Agatston: 10%/18%/12%, volume: 10%/12%/10% and mass: 8%/13%/11% for observer 1 and Agatston: 8%/14%/10%, volume: 7%/9%/10% and mass: 7%/10%/9% for observer 2, respectively. The mean interobserver variability was 5% to 14%. In conclusion, prospective electrocardiograph-triggered 64-slice CT using the 1.25-mm prospective scan shows the lowest variability. The 2.5-mm prospective scan on volume or mass scoring shows variability of around 10%, comparable to 2.5-mm-thickness spiral overlapping reconstruction images.

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“…In patients with suspected CAD, the combined perfusion and CAC analysis improves the detection of obstructive CAD, supporting the routine application of such an approach. Because most current PET scanners have at least 16-slice CT, which is sufficient for CAC scoring, an additional CAC scan is easily accommodated by the hybrid 82 Rb PET/CT MPI protocol (28). In addition, software techniques have been proposed for PET/CT, which can register a single CAC scan to PET for attenuation correction of stress and rest PET (29).…”

Section: Discussionmentioning

confidence: 99%

Combined Quantitative Assessment of Myocardial Perfusion and Coronary Artery Calcium Score by Hybrid ⁸²Rb PET/CT Improves Detection of Coronary Artery Disease

et al. 2015

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Hybrid PET myocardial perfusion imaging (MPI) with CT allows the incorporation of coronary artery calcium (CAC) into the clinical protocol. We aimed to determine whether the combined analysis of MPI and CAC could improve the diagnostic accuracy of PET MPI in detection of obstructive coronary artery disease (CAD). Methods: Consecutive patients (n 5 152; mean age ± SD, 69 ± 12 y) without prior CAD, referred to 82 Rb PET MPI followed by invasive coronary angiography performed within 14 days, were studied. Myocardial perfusion was quantified automatically for left anterior descending, left circumflex, and right coronary artery territories as an ischemic total perfusion deficit (ITPD) for 456 vessels. Global and per-vessel CAC Agatston scores were calculated. Obstructive CAD was defined as 50% or greater stenosis of the left main and 70% or greater stenosis in the left anterior descending, left circumflex, and right coronary arteries. Logistic regression and 10-fold cross validation were used to derive and validate the combined ITPD/logCAC (logarithm of coronary calcium) scores. Results: In the prediction of per-vessel obstructive CAD, the receiver-operating-characteristic area under the curve for combined per-vessel ITPD/logCAC score was higher, 0.85 (95% confidence interval [CI], 0.81-0.89), than standalone ITPD area under the curve, 0.81 (95% CI: 0.76-0.85), and logCAC score, 0.73 (95% CI, 0.68-0.78; P , 0.05). The integrated discrimination improvement of combined per-vessel ITPD/logCAC analysis was 0.07 (95% CI, 0.04-0.09; P , 0.0001), as compared with ITPD alone. Conclusion: Combined automatically derived per-vessel ITPD and logCAC score improves accuracy of 82 Rb PET MPI for detection of obstructive CAD.Key Words: hybrid cardiac positron emission tomography; coronary calcium score; detection of obstructive coronary artery disease

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The accuracy of 1- and 3-mm slices in coronary calcium scoring using multi-slice CT in vitro and in vivo

Cited by 30 publications

References 37 publications

Image quality of multiplanar reconstruction of pulmonary CT scans using adaptive statistical iterative reconstruction

Image quality of multiplanar reconstruction of pulmonary CT scans using adaptive statistical iterative reconstruction

Variability of repeated coronary artery calcium measurements by 1.25-mm- and 2.5-mm-thickness images on prospective electrocardiograph-triggered 64-slice CT

Combined Quantitative Assessment of Myocardial Perfusion and Coronary Artery Calcium Score by Hybrid ⁸²Rb PET/CT Improves Detection of Coronary Artery Disease

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The accuracy of 1- and 3-mm slices in coronary calcium scoring using multi-slice CT in vitro and in vivo

Cited by 30 publications

References 37 publications

Image quality of multiplanar reconstruction of pulmonary CT scans using adaptive statistical iterative reconstruction

Image quality of multiplanar reconstruction of pulmonary CT scans using adaptive statistical iterative reconstruction

Variability of repeated coronary artery calcium measurements by 1.25-mm- and 2.5-mm-thickness images on prospective electrocardiograph-triggered 64-slice CT

Combined Quantitative Assessment of Myocardial Perfusion and Coronary Artery Calcium Score by Hybrid 82Rb PET/CT Improves Detection of Coronary Artery Disease

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Combined Quantitative Assessment of Myocardial Perfusion and Coronary Artery Calcium Score by Hybrid ⁸²Rb PET/CT Improves Detection of Coronary Artery Disease