The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products

Bazán, Haydee E. P.; Reddy, S.; Woodland, Joseph; Bazán, Nicolás G.

doi:10.1016/0006-291x(87)90495-5

Cited by 39 publications

(8 citation statements)

References 20 publications

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“…PAF has also been found in the cornea, iris, ciliary body and retina (6)(7)(8). PAF administered to ocular tissues by various routes causes diverse but comparably intense reactions in these tissues.…”

Section: Introductionmentioning

confidence: 99%

The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs

Tsuji

Shirasawa

1998

Current Eye Research

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Section: Introductionmentioning

confidence: 99%

The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs

Tsuji

Shirasawa

1998

Current Eye Research

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“…It is generated by a variety of cells implicated in inflammation. In the cornea after injury there is a rapid accumulation of PAF [41,42]. The use of selective PAF antagonists in rabbits with alkaliburned corneas produces an inhibition of the lipoxygenase pathway (Fig.…”

Section: Platelet-activating Factormentioning

confidence: 99%

Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis

et al. 1990

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The cellular and biochemical events triggered by uveitis involve a complex array of cells and a heterogeneous network of mediators of intraocular inflammation. Resident cells are activated and inflammatory cells are recruited. Chemical mediators from the arachidonic acid cascade, prostaglandins, hydroxyeicosatetraenoic acids, and leukotrienes, are formed. Several of these metabolites are modulators of cellular functions, but when generated in sustained, excessive amounts, they contribute to enhanced vascular permeability and to the onset of pathophysiological responses. Another very active membrane-derived mediator is platelet-activating factor. This important mediator of immune and inflammatory responses may play a central role in uveitis due to cell priming, since interleukin-1, tumor necrosis factor, and other as yet unidentified mediators are also being generated. The concomitant accumulation of these networks of mediators in various parts of the uveal tract leads to spreading of the intraocular inflammatory response and cellular damage. At both early and late stages of uveitis, the generation of free radicals is also a major contributor to the impairment of function. Free radicals are generated in two distinct sites: in the oxidative burst of recruited white cells and in free radical formation and lipid peroxidation in resident cells. The identification of the cellular events that lead to the accumulation of networks of mediators of inflammation and their effects has important therapeutic implications in uveitis.

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“…It was originally found in the chick retina and was shown to be able to alter vascular permeability in the rabbit retina (Bazan et al 1987). PAF was also described as a trigger of prostaglandin synthesis by iris smooth muscle (Yousufzai and Abdel-Latif 1985).…”

Section: Introductionmentioning

confidence: 99%

Dynamics of PAF-induced conjunctivitis reveals differential expression of PAF receptor by macrophages and eosinophils in the rat

Zinchuk

Fukushima

Hangstefer³

et al. 2004

Cell Tissue Res

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The action of platelet-activating factor (PAF) toward the PAF receptor (PAF-R) plays an important role in inflammation. We employed immunohistochemistry and quantitative confocal immunofluorescence microscopy to examine the dynamic changes of PAF-R expression in the conjunctiva in response to PAF-induced conjunctivitis in Brown Norway rats within the first 2 h after topical administration of PAF. Instillation of PAF caused an alteration in pattern of recruitment of macrophages and eosinophils into the conjunctiva, as was visualized by immunohistochemical staining for the antigens ED 1 and ED 2 (markers of macrophages) and MBP (a marker of eosinophils). An increase in the number of PAF-R positive cells was alos detected. Quantitative colocalization analysis revealed ther strongest rise in the degree of PAF-R expression by macrophages within the first 6 h, whereas their infiltration increased throughout the period of observation. However, eosinophils showed a high degree of PAF-R expression during all 24 h of the experiment, although they infiltrated strongly only within the first 2 h. Thus, for the first time, the use of quantitative colocalization analysis software developed by us has reveal intrinsic details of the interaction of PAF anf PAF-R in conjunctivitis, findings not otherwise obtainable by using qualitative approaches alone. Our results provide a theoretical basis for a definition of the proper time-frame in which to prevent and control the infiltration of macrophages and eosinophils into the conjunctiva.

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The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products

Cited by 39 publications

References 20 publications

The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs

The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs

Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis

Dynamics of PAF-induced conjunctivitis reveals differential expression of PAF receptor by macrophages and eosinophils in the rat

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