The accumulation and toxicity of ZIF-8 nanoparticles in Corbicula fluminea

Yang, Cuilian; Wen, Jia; Xue, Zhuangzhuang; Yin, Xiyan; Li, Yangfang; Li, Yuan

doi:10.1016/j.jes.2022.03.020

Cited by 12 publications

(7 citation statements)

References 47 publications

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“…In contrast, combined exposure to CPC and 60-mg/L ZIF-NPs did not significantly increase the MDA level in zebrafish larvae; even this mixture significantly elevated their ROS level and decreased their T-SOD activity. A possible explanation is the dose-specific effects of ZIF-NPs on organisms, which have been well documented by recent studies [11,44,45]. Another possible explanation is that the interactions between components in mixtures exhibit complex effects on their joint toxicity, which is affected by many factors, such as the combination of a mixture, their dose level, dose ratio, and others [46,47].…”

Section: Discussionmentioning

confidence: 86%

Zeolitic Imidazolate Framework-8 Nanoparticles Exhibit More Severe Toxicity to the Embryo/Larvae of Zebrafish (Danio rerio) When Co-Exposed with Cetylpyridinium Chloride

Qiu

Liu

et al. 2022

Antioxidants

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The combined application of nanoparticles and surfactants has attracted tremendous attention in basic research and industry. However, knowledge of their combined toxicity remains scarce. In this study, we exposed zebrafish embryos to cetylpyridinium chloride (CPC, a cationic surfactant, at 0 and 20 μg/L), zeolitic imidazolate framework nanoparticles (ZIF-NPs, at 0, 30, and 60 mg/L), and their mixtures until 120 h post-fertilization (hpf). Within the used concentration range, both single and combined exposures exhibited limited effects on the survival and hatching of zebrafish. However, the combined exposure of ZIF-NPs and CPC caused more severe effects on the heart rate at both 48 and 72 hpf. The combined exposure also induced significant hyperactivity (i.e., increasing the average swimming velocity) and oxidative stress in zebrafish larvae (at 120 hpf), although all single exposure treatments exhibited limited impacts. Furthermore, the level of reactive oxygen species (or malondialdehyde) exhibited a significantly positive correlation with the heart rate (or average swimming velocity) of zebrafish, suggesting that oxidative stress plays a role in mediating the combined toxicity of CPC and ZIF-NPs to zebrafish. Our findings suggest that the interaction of CPC and ZIF-NPs should not be ignored when assessing the potential risks of their mixtures.

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Section: Discussionmentioning

confidence: 86%

Zeolitic Imidazolate Framework-8 Nanoparticles Exhibit More Severe Toxicity to the Embryo/Larvae of Zebrafish (Danio rerio) When Co-Exposed with Cetylpyridinium Chloride

Qiu

Liu

et al. 2022

Antioxidants

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“…The formation mechanism of the novel 3D mesoporous ZIF-8-Cu and β-G@ZIF-8-Cu was tested by XPS. The N 1s peaks of the complex ZIF-8-Cu and β-G@ZIF-8-Cu were significantly shifted toward a high binding energy (398.9 to 399.2 eV and 399.0 to 399.3 eV) compared to pure ZIF-8 and β-G@ZIF-8 (Figures b and S5b), which indicated that the N was coordinated with Cu and a new Cu–N bond was generated. , In addition, for the absorption peak of the entire imidazole ring, the absorption peak at 1311 cm –1 was markedly enhanced with the introduction of CuCl, further confirming the coordination between Cu and N (Figures d and S6). The formation of a new coordinate covalent bond was bound to affect the original coordination, so the chemical environment of Zn was tested by XPS.…”

Section: Results and Discussionmentioning

confidence: 95%

Encapsulating β-Glucosidase within Nanoporous ZIF-8-Cu Nanoparticles Enables High-Temperature Activity

Jiao,

Wang,

Pang

et al. 2023

ACS Appl. Nano Mater.

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Recently, metal–organic frameworks (MOFs) have become a promising carrier for immobilized enzymes. However, the long transmission distance and microporous nature of traditional 3D ZIF-8 materials not only reduce the accessibility of the enzyme and the substrate, but also the enzymes “encapsulated” by microporous ZIF-8 suffer compromising enzyme activity (<10% of the original enzyme activity). In this article, a method is proposed to construct one kind of new-type mesoporous 3D ZIF-8-Cu composed of 2D nanostructures that utilize a metal competitive coordination-induced defect structure by adjusting a metal guide agent copper chloride (CuCl). In addition, the feasibility of in situ encapsulating β-G within the developed mesoporous 3D ZIF-8-Cu endows that the enzyme complex (β-G@ZIF-8-Cu) possessed remarkably enhanced synergistic catalysis ability. The enzyme activity of mesoporous β-G@ZIF-8-Cu (with respect to cellobiose) was up to 50.1%, while that of 3D microporous β-G@ZIF-8 was only 5.1% at 50 °C. Significantly, with the increase of temperature, the enzyme activity of mesoporous β-G@ZIF-8-Cu increased as high as approximately 178.3%, almost 34.2 times that of β-G@ZIF-8 (5.2%) at 90 °C. This improvement results from the expansion of pores (significantly increased at 10∼50 nm), promoting substrate diffusion, and the thinner 2D structure shortened the mass transfer distance, accelerating the transport rate of reactants. In addition, 3D mesoporous β-G@ZIF-8-Cu composed of multilayer 2D nanostructures with better high-temperature resistance.

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“…Hu et al [15] have reported that ZIF-8 nanoparticles induce neurobehavioral disorders through the regulation of ROS-mediated oxidative stress in zebrafish embryos, and Chen et al [16] have found that oxidative damage was one of the main reasons for changing the behavioral responses to light-to-dark transitions in zebrafish larvae exposed to nanoplastics. Moreover, Yang et al [17] also found that exposure to ZIF-8 NPs induced oxidative stress behaviors similar to the hormesis effect in the tissues of the Asian clam (Corbicula fluminea (O. F. Müller, 1774)). Thus, oxidative stress induced by nanoparticles can be considered one of the important mechanisms for their toxic effects.…”

Section: Introductionmentioning

confidence: 88%

ZIF-8 Nanoparticles Induce Behavior Abnormality and Brain Oxidative Stress in Adult Zebrafish (Danio rerio)

et al. 2023

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Zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) are typical metal–organic framework (MOF) materials and have been intensively studied for their potential application in drug delivery and environmental remediation. However, knowledge of their potential risks to health and the environment is still limited. Therefore, this study exposed female and male zebrafish to ZIF-8 NPs (0, 9.0, and 90 mg L−1) for four days. Subsequently, variations in their behavioral traits and brain oxidative stress levels were investigated. The behavioral assay showed that ZIF-8 NPs at 90 mg/L could significantly decrease the locomotor activity (i.e., hypoactivity) of both genders. After a ball falling stimulation, zebrafish exposed to ZIF-8 NPs (9.0 and 90 mg L−1) exhibited more freezing states (i.e., temporary cessations of movement), and males were more sensitive than females. Regardless of gender, ZIF-8 NPs exposure significantly reduced the SOD, CAT, and GST activities in the brain of zebrafish. Correlation analysis revealed that the brain oxidative stress induced by ZIF-8 NPs exposure might play an important role in their behavioral toxicity to zebrafish. These findings highlight the necessity for further assessment of the potential risks of MOF nanoparticles to aquatic species and the environment.

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The accumulation and toxicity of ZIF-8 nanoparticles in Corbicula fluminea

Cited by 12 publications

References 47 publications

Zeolitic Imidazolate Framework-8 Nanoparticles Exhibit More Severe Toxicity to the Embryo/Larvae of Zebrafish (Danio rerio) When Co-Exposed with Cetylpyridinium Chloride

Zeolitic Imidazolate Framework-8 Nanoparticles Exhibit More Severe Toxicity to the Embryo/Larvae of Zebrafish (Danio rerio) When Co-Exposed with Cetylpyridinium Chloride

Encapsulating β-Glucosidase within Nanoporous ZIF-8-Cu Nanoparticles Enables High-Temperature Activity

ZIF-8 Nanoparticles Induce Behavior Abnormality and Brain Oxidative Stress in Adult Zebrafish (Danio rerio)

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