The accessory body of Cajal in nerve cell nuclei of the cat

Thompson, Bertha K.; Haggar, Robert A.; Barr, Murray L.

doi:10.1002/cne.901080205

Cited by 14 publications

(3 citation statements)

References 7 publications

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“…Stimulated by the demonstration of the sex chromatin (later identified as the inactive X chromosome) in mammalian female nuclei, Barr's team published three papers (Haggar 1957;Nayyar and Barr 1968;Thompson et al 1957) on the organization of the accessory body in feline neurons using the silver nitrate modification of Nauta and Gyrax and the cytochemical method of Feulgen (for DNA). The authors confirmed Cajal's observations, performed a quantitative analysis of the incidence of accessory bodies in several nervous centers, reported the infrequent appearance, in feline neurons, of an argyrophilic paranuclear structure, which may be a precursor of the accessory body free in the nucleoplasm, and demonstrated that, unlike the sex chromatin, the accessory body is Feulgen negative.…”

Section: The Accessory Body ("Cajal Body")mentioning

confidence: 99%

Cajal’s contribution to the knowledge of the neuronal cell nucleus

et al. 2009

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In 1906, the Spanish neurobiologist Santiago Ramón y Cajal was awarded the Nobel Prize in Physiology or Medicine in recognition of his work on the structure of neurons and their connections. Cajal is commonly regarded as the father of modern neuroscience. What is less well known is that Cajal also had a great interest in intracellular neuronal structures and developed the reduced silver nitrate method for the study of neurofibrils (neurofilaments) and nuclear subcompartments. It was in 1903 that Cajal discovered the "accessory body" ("Cajal body") and seven years later, published an article on the organization of the cell nucleus in mammalian neurons that represents a masterpiece of nuclear structure at the light microscopy level. In addition to the accessory body, it includes the analysis of several nuclear components currently recognized as fibrillar centers of the nucleolus, nuclear speckles of splicing factors, transcription foci, nuclear matrix, and the double nuclear membrane. The aim of this article is to revisit Cajal's contributions to the knowledge of the neuronal nucleus in light of our current understanding of nuclear structure and function.

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Section: The Accessory Body ("Cajal Body")mentioning

confidence: 99%

Cajal’s contribution to the knowledge of the neuronal cell nucleus

et al. 2009

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“…Barr's team confirmed Cajal's observations in feline neurons and, with the cytochemical method of Feulgen, they demonstrated that the accessory body, unlike the sex chromatin, is relatively DNA poor. [17][18][19] It was not until 1969 that the first observation of the accessory body was made in non-neuronal tissue. By electron microscopy, Monneron and Bernhard (1969) reported a nuclear structure composed of dense coiled threads in hepatocytes and gave it the name of "coiled body" (Fig.…”

Section: 99mentioning

confidence: 99%

Cajal bodies in neurons

et al. 2016

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“…These accessory bodies, however, are granular rather than threadlike in form, and they have a less structured matrix. They are believed by some investigators to be of nucleolar origin (13,14,56), and they reportedly contain large FIGURES 18 A and B Nerve cell process containing an unidentified aggregate of dense masses which may represent a special form of the nematosome . The masses have a mottled appearance, an irregular outline, and radiating filaments which occupy much of the space between them .…”

Section: Possible Relationship To Nuclear Componentsmentioning

confidence: 99%

Cytoplasmic Inclusions Resembling Nucleoli in Sympathetic Neurons of Adult Rats

Grillo

1970

The Journal of Cell Biology

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A distinctive cytoplasmic inclusion consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix was identified in the neurons, but not in the supporting cells, of rat sympathetic ganglia . This ball-like structure, designated "nematosome," measures -0 .9 .s and lacks a limiting membrane . Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles -25-50 A thick . Cytochemical studies carried out with the light microscope suggest the presence of nonhistone proteins and some RNA . Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells . Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles . In fine structure and stainability, they bear a resemblance to the fibrous component of the nucleolus . Subsynaptic formations, which are a special feature of some of the synapses in sympathetic ganglia, appear similar to the threadlike elements in the nematosomes . The possibility that these three structures-nucleolus, nematosome, and subsynaptic formation-may be interrelated in origin and function is discussed .

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The accessory body of Cajal in nerve cell nuclei of the cat

Cited by 14 publications

References 7 publications

Cajal’s contribution to the knowledge of the neuronal cell nucleus

Cajal’s contribution to the knowledge of the neuronal cell nucleus

Cajal bodies in neurons

Cytoplasmic Inclusions Resembling Nucleoli in Sympathetic Neurons of Adult Rats

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