The Access Randomized Clinical Trial of Public Versus Private Physiotherapy for Low Back Pain

Casserley-Feeney, Sarah N.; Daly, Leslie; Hurley, Deirdre A.

doi:10.1097/brs.0b013e3182127457

Cited by 15 publications

(9 citation statements)

References 50 publications

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“…Although also for Casserley-Feeney et al 29 EQ-5D and RMDQ presented similar results, this latter study evidenced that RMDQ is more sensitive than EQ-5D to small differences at low levels of disability. This lack of sensitivity to change in health states seems confirmed also by other studies.…”

Section: Resultssupporting

confidence: 77%

“… 25 , 28 , 29 , 31 , 33 , 36 , 41 Carr et al , 28 for instance, registered an increase in EQ-5D mean values from baseline to 3 months of 0.028 and from baseline to 12 months of 0.045 for the individual physiotherapy group, whereas improvements for the group exercise were milder. Similarly, Casserley-Feeney et al 29 reported EQ-5D to differ between public physiotherapy and private physiotherapy patients, Djas and Kalim 33 for the instrument to be sensitive to differences between patients undergoing radiography and patients not undergoing radiography and Wilkens et al 41 for the measurement to recognize patients administered with glucosamine and patients administered with placebo. Bastiaenen et al , 25 Hellum et al , 36 and Cox et al 31 reported similar results.…”

Section: Resultsmentioning

confidence: 97%

“…In studies conducted by Bastiaenen et al , 25 Carr et al , 28 Casserley-Feeney et al , 29 Djas and Kalim, 33 Gilbert et al , 34 , 35 Hurley et al 37 Jansson et al , 60 and Wilkens et al 41 EQ-5D values appeared responsive to improvements because of the treatment of LBP, although these were not statistically significant.…”

Section: Resultsmentioning

confidence: 97%

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Generic Preference-based Measures for Low Back Pain

Finch

Dritsaki

Jommi

2016

SPINE

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Study Design.Systematic review.Objective.This systematic review examines validity and responsiveness of three generic preference-based measures in patients with low back pain (LBP).Summary of Background Data.LBP is a very common incapacitating disease with a significant impact on health-related quality of life (HRQoL). Health state utility values can be derived from various preference-based HRQoL instruments, and among them the most widely ones are EuroQol 5 dimensions (EQ-5D), Short Form 6 Dimensions (SF-6D), and Health Utilities Index 3 (HUI III). The ability of these instruments to reflect HRQoL has been tested in various contexts, but never for LBP populations.Methods.A systematic search on electronic literature databases was undertaken to identify studies of patients with LBP where health state utility values were reported. Records were screened using a set of predefined eligibility criteria. Data on validity (correlations and known group methods) and responsiveness (effect sizes, standardized response means, tests of statistical significance) of instruments were extracted using a customized extraction template, and assessed using predefined criteria.Results.There were substantial variations in the 37 included papers identified in relation to study design and outcome measures used. EQ-5D demonstrated good convergent validity, as it was able to distinguish between known groups. EQ-5D was also able to capture changes of health states as results of different interventions. Evidence for SF-6D and HUI III was limited to allow an appropriate evaluation.Conclusion.EQ-5D performs well in LBP population and its scores seem to be suitable for economic evaluation of LBP interventions. However, the paucity of information on the other instruments makes it impossible to determine its relative validity and responsiveness compared with them.Level of Evidence: 2

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Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 97%

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Generic Preference-based Measures for Low Back Pain

Finch

Dritsaki

Jommi

2016

SPINE

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“…The EQ5D is a widely used health‐related quality of life (QoL) measure that contains five domains, namely, mobility, self‐care, usual activities, pain/discomfort, and anxiety/depression and includes a VAS for overall health . It has been shown to be applicable to, and valid for, a wide range of health conditions and treatments .…”

Section: Methodsmentioning

confidence: 99%

Allogeneic MSCs and Recycled Autologous Chondrons Mixed in a One-Stage Cartilage Cell Transplantion: A First-in-Man Trial in 35 Patients

et al. 2017

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MSCs are known as multipotent mesenchymal stem cells that have been found capable of differentiating into various lineages including cartilage. However, recent studies suggest MSCs are pericytes that stimulate tissue repair through trophic signaling. Aimed at articular cartilage repair in a one-stage cell transplantation, this study provides first clinical evidence that MSCs stimulate autologous cartilage repair in the knee without engrafting in the host tissue. A phase I (first-in-man) clinical trial studied the one-stage application of allogeneic MSCs mixed with 10% or 20% recycled defect derived autologous chondrons for the treatment of cartilage defects in 35 patients. No treatment-related serious adverse events were found and statistically significant improvement in clinical outcome shown. Magnetic resonance imaging and second-look arthroscopies showed consistent newly formed cartilage tissue. A biopsy taken from the center of the repair tissue was found to have hyaline-like features with a high concentration of proteoglycans and type II collagen. DNA short tandem repeat analysis delivered unique proof that the regenerated tissue contained patient-DNA only. These findings support the hypothesis that allogeneic MSCs stimulate a regenerative host response. This first-in-man trial supports a paradigm shift in which MSCs are applied as augmentations or "signaling cells" rather than differentiating stem cells and opens doors for other applications. Stem Cells 2017;35:1984-1993.

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“…was measured in the patients with hip arthroplasty. Subjective outcome and satisfaction are known to be different constructs that are able to act independently of each other [22]. The low ceiling effect of both types of GSOS encourages their use in both clinical and research situations from this perspective.…”

Section: Utilitymentioning

confidence: 98%