“…Previous studies have addressed the relationships between BMI and each year of age at T1D onset (6)(7)(8)(9)(10)(11), progression to T1D (5,(18)(19)(20)(21), and beta-cell function (22), but their results were conflicting. The validity and potential underlying pathogenesis of the 'accelerator hypothesis' remain controversial (23)(24)(25)(26)(27).…”
Obese and overweight children compared to lean children have greater beta-cell function at the onset of autoimmune T1D. Prospective studies on the relationships among BMI, beta-cell function, and progression to clinical T1D are warranted.
“…Previous studies have addressed the relationships between BMI and each year of age at T1D onset (6)(7)(8)(9)(10)(11), progression to T1D (5,(18)(19)(20)(21), and beta-cell function (22), but their results were conflicting. The validity and potential underlying pathogenesis of the 'accelerator hypothesis' remain controversial (23)(24)(25)(26)(27).…”
Obese and overweight children compared to lean children have greater beta-cell function at the onset of autoimmune T1D. Prospective studies on the relationships among BMI, beta-cell function, and progression to clinical T1D are warranted.
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