The accelerated occurrence of age-related changes of organism in Chernobyl workers: A radiation-induced progeroid syndrome?

Polyukhov, A.M.; Kobsar, I.V.; Grebelnik, V.I.; Voitenko, V. P.

doi:10.1016/s0531-5565(99)00081-9

Cited by 19 publications

(12 citation statements)

References 25 publications

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“…There are many consistent reports about characteristic neurophysiological (Danilov & Pozdeev, 1994;Zhavoronkova, Kholodova, Zubovskii, Smirnov, Koptelov, & Ryzhov, 1995;Zhavoronkova, Kholodova, Zubovsky, Gogitidze, & Koptelov, 1995;Novikov, Tsygan, Borisova, & Rybina, 1997;Vyatleva, Katargina, Puchinskaya, & Yurkin, 1997;Zhavoronkova, Kholodova, Belostocky, & Koulikov, 2008), neuropsychological Data Science Journal, Volume 8, 24 September 2009(Khomskaja, 1995Zhavoronkova, Gogitidze, & Kholodova, 1996Polyukhov, Kobsar, Grebelnik, & Voitenko, 2000;Turuspekova, 2002;Gamache, Levinson, Reeves, Bidyuk, & Brantley, 2005;Zhavoronkova, Lavrova, Belostotskii, Kholodova, Skoriatina, & Voronov, 2006), neuroimaging (Kharchenko, Zubovskii, & Kholodova, 1995;Kholodova, Kuznetzova, Zubovsky, Kazakova, & Buklina, 1996;Voloshina, 1997), and neuroimmune (Lysyanyj, 1998;Nikolenko, Bondarenko, Bazyka, Golovchenko, Nikolenko, & Dubiaga, 2002) abnormalities in liquidators, supporting the clinical data about organic brain damage (Chuprikov, Pasechnik, Kryzhanovskaja, & Kazakova, 1992;Krasnov, Yurkin, Vojtsekh, Skavysh, Gorobets, Zubovsky, et al, 1993;Romodanov et al, 1993;Romodanov & Vynnyts'kyj, 1993;Napreyenko & Loganovsky, 1995, 1997, 1999, 2001Revenok, 1998Revenok, , 1999Zozulya et al, 1998;Morozov & Kryzhanovskaja, 1998;Rumyantseva, Chinkina, & Levina, 2002;Soldatkin, 2002). In summary, these reports testify to the organic brain damage and accelerating CNS aging in clean-up workers following...…”

Section: 44mentioning

confidence: 92%

Do Low Doses of Ionizing Radiation Affect the Human Brain?

Loganovsky

2009

Data Sci. J.

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Section: 44mentioning

confidence: 92%

Do Low Doses of Ionizing Radiation Affect the Human Brain?

Loganovsky

2009

Data Sci. J.

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“…Liquidators younger than 45 years of age were more vulnerable. The biological age of liquidators who worked at the Chernobyl catastrophe site in the first 4 months after the meltdown exceeds the biological age of those who labored there subsequently (Polyukhov et al , 2000). It is proposed that the accelerated occurrence of age‐related changes in organs of liquidators is a radiation‐induced progeroid syndrome (Polyukhov et al , 2000; Bebeshko et al , 2006).…”

Section: Accelerated Aging As a Consequence Of The Chernobyl Catasmentioning

confidence: 99%

Chapter II. Consequences of the Chernobyl Catastrophe for Public Health

Nesterenko¹,

Nesterenko²,

Yablokov

2009

Annals of the New York Academy of Sciences

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Problems complicating a full assessment of the effects from Chernobyl included official secrecy and falsification of medical records by the USSR for the first 3.5 years after the catastrophe and the lack of reliable medical statistics in Ukraine, Belarus, and Russia. Official data concerning the thousands of cleanup workers (Chernobyl liquidators) who worked to control the emissions are especially difficult to reconstruct. Using criteria demanded by the International Atomic Energy Agency (IAEA), the World Health Organization (WHO), and the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) resulted in marked underestimates of the number of fatalities and the extent and degree of sickness among those exposed to radioactive fallout from Chernobyl. Data on exposures were absent or grossly inadequate, while mounting indications of adverse effects became more and more apparent. Using objective information collected by scientists in the affected areas--comparisons of morbidity and mortality in territories characterized by identical physiography, demography, and economy, which differed only in the levels and spectra of radioactive contamination--revealed significant abnormalities associated with irradiation, unrelated to age or sex (e.g., stable chromosomal aberrations), as well as other genetic and nongenetic pathologies.

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“…21,24 Chronic irradiation, indeed, induces features of accelerated senescence. 40,41 However, the levels of natural radioactivity are usually too low to be of substantial importance in causing aging and, paradoxically, very low doses of ionizing radiation (somewhat higher than background) may even increase life span. 42 Overall, Harman's free radical theory accords well with major characteristics of aging.…”

Section: Oxidative Stress As a Major Cause Of Damage Under Normal Conmentioning

confidence: 99%

Garbage catastrophe theory of aging: imperfect removal of oxidative damage?

Terman

2001

Redox Report

139

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Increasing evidence suggests an important role of oxidant-induced damage in the progress of senescent changes, providing support for the free radical theory of aging proposed by Harman in 1956. However, considering that biological organisms continuously renew their structures, it is not clear why oxidative damage should accumulate with age. No strong evidence has been provided in favor of the concept of aging as an accumulation of synthetic errors (e.g. Orgel's 'error-catastrophe' theory and the somatic mutation theory). Rather, we believe that the process of aging may derive from imperfect clearance of oxidatively damaged, relatively indigestible material, the accumulation of which further hinders cellular catabolic and anabolic functions. From this perspective, it might be predicted that: (i) suppression of oxidative damage would enhance longevity; (ii) accumulation of incompletely digested material (e.g. lipofuscin pigment) would interfere with cellular functions and increase probability of death; (iii) rejuvenation during reproduction is mainly provided by dilution of undigested material associated with intensive growth of the developing organism; and (iv) age-related damage starts to accumulate substantially when development is complete, and mainly affects postmitotic, cells and extracellular matrix, not proliferating cells. There is abundant support for all these predictions.

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The accelerated occurrence of age-related changes of organism in Chernobyl workers: A radiation-induced progeroid syndrome?

Cited by 19 publications

References 25 publications

Do Low Doses of Ionizing Radiation Affect the Human Brain?

Do Low Doses of Ionizing Radiation Affect the Human Brain?

Chapter II. Consequences of the Chernobyl Catastrophe for Public Health

Garbage catastrophe theory of aging: imperfect removal of oxidative damage?

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