The Absorption of Radioiron Labeled Foods and Iron Salts in Normal and Iron-Deficient Subjects and in Idiopathic Hemochromatosis

Chodos, Robert B.; Ross, Joseph F.; Apt, Leonard; Pollycove, Myron; Halkett, James A. E.

doi:10.1172/jci103427

Cited by 98 publications

(26 citation statements)

References 25 publications

(22 reference statements)

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“…392 (5) or in which various foodstuffs were biosynthetically labeled (6)(7)(8) suggest an absorption of about 5 per cent or 0.75 mg. per day from a normal diet.…”

Section: Resultsmentioning

confidence: 99%

Body Iron Exchange in Man*

Finch¹

1959

J. Clin. Invest.

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The present studies were undertaken to measure total body iron turnover in man. The assumptions were made: a) that the adult is in iron equilibrium, and b) that it is possible by the intravenous injection of iron to label body iron uniformly to the extent that blood sampling will reflect iron exchange. Such studies had previously been carried out in animals and the premise was shown to be generally valid (1). This report indicates the approximate period of time required for uniform labeling of miscible iron, and characterizes the total iron turnover in normal men, in nonmenstruating and in menstruating women. MATERIALS AND METHODSPatients in the Northern State Hospital were selected for study because of their good health and normal hematologic findings, and absence of history of abnormal blood loss or anemia. They were divided into three groups. Group I was composed of 6 adult men, Group II of 12 adult nonmenstruating women and Group III of 6 adult menstruating women. Pertinent hematologic data are summarized in Table I.Hematocrit, plasma iron and reticulocyte determinations were performed initially and at the end of the study on venous blood samples from these patients. The plasma iron method employed was that of Bothwell and Mallett (2) Figure 1, and average data in the 'This is based on the determination of the amount of radioiron in circulation in five normal subjects at 60 days, employing Cr' to estimate red cell mass (4). 392

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“…392 (5) or in which various foodstuffs were biosynthetically labeled (6)(7)(8) suggest an absorption of about 5 per cent or 0.75 mg. per day from a normal diet.…”

Section: Resultsmentioning

confidence: 99%

Body Iron Exchange in Man*

Finch¹

1959

J. Clin. Invest.

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“…The principle of employing biosynthetically tagged foods, described originally by Moore and Dubach (1) has been applied extensively in studies of iron availability from various plant and vegetable foods (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Although these studies have yielded useful information, this kind of approach has serious limitations.…”

Section: Introductionmentioning

confidence: 99%

Food Iron Absorption Measured by an Extrinsic Tag

Cook¹,

Layrisse²,

et al. 1972

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“…The effect of food on absorption of hemoglobin iron. Food has been shown to reduce absorption of small amounts of iron salt by approximately one-half (2,16,17). This effect was co1-firmed in three normal subjects who were given on successive days 5 mg iron as ferrous sulfate and 80 mg ascorbic acid with and without a moderately large meal containing 4.4 mg of iron.…”

mentioning

confidence: 95%